Maternal cholestasis during pregnancy programs metabolic disease in offspring
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The infl...
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Online Access: | https://boris.unibe.ch/43271/1/23934127.pdf https://boris.unibe.ch/43271/ |
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ftunivbern:oai:boris.unibe.ch:43271 2023-08-20T04:08:43+02:00 Maternal cholestasis during pregnancy programs metabolic disease in offspring Papacleovoulou, Georgia Abu-Hayyeh, Shadi Nikolopoulou, Evanthia Briz, Oscar Owen, Bryn M. Nikolova, Vanya Ovadia, Caroline Huang, Xiao Vaarasmaki, Marja Baumann, Marc Jansen, Eugene Albrecht, Christiane Jarvelin, Marjo-Riitta Marin, Jose J. G. Knisely, A. S. Williamson, Catherine 2013-07-01 application/pdf https://boris.unibe.ch/43271/1/23934127.pdf https://boris.unibe.ch/43271/ eng eng American Society for Clinical Investigation https://boris.unibe.ch/43271/ info:eu-repo/semantics/openAccess Papacleovoulou, Georgia; Abu-Hayyeh, Shadi; Nikolopoulou, Evanthia; Briz, Oscar; Owen, Bryn M.; Nikolova, Vanya; Ovadia, Caroline; Huang, Xiao; Vaarasmaki, Marja; Baumann, Marc; Jansen, Eugene; Albrecht, Christiane; Jarvelin, Marjo-Riitta; Marin, Jose J. G.; Knisely, A. S.; Williamson, Catherine (2013). Maternal cholestasis during pregnancy programs metabolic disease in offspring. Journal of clinical investigation, 123(7), pp. 3172-3181. American Society for Clinical Investigation 10.1172/JCI68927 <http://dx.doi.org/10.1172/JCI68927> 610 Medicine & health 570 Life sciences biology info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed 2013 ftunivbern https://doi.org/10.1172/JCI68927 2023-07-31T21:03:16Z The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland birth cohort 1985-1986 database and found that 16-year-old children of mothers with ICP had altered lipid profiles. Males had increased BMI, and females exhibited increased waist and hip girth compared with the offspring of uncomplicated pregnancies. We further investigated the effect of maternal cholestasis on the metabolism of adult offspring in the mouse. Females from cholestatic mothers developed a severe obese, diabetic phenotype with hepatosteatosis following a Western diet, whereas matched mice not exposed to cholestasis in utero did not. Female littermates were susceptible to metabolic disease before dietary challenge. Human and mouse studies showed an accumulation of lipids in the fetoplacental unit and increased transplacental cholesterol transport in cholestatic pregnancy. We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring. Article in Journal/Newspaper Northern Finland BORIS (Bern Open Repository and Information System, University of Bern) Journal of Clinical Investigation 123 7 3172 3181 |
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BORIS (Bern Open Repository and Information System, University of Bern) |
op_collection_id |
ftunivbern |
language |
English |
topic |
610 Medicine & health 570 Life sciences biology |
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610 Medicine & health 570 Life sciences biology Papacleovoulou, Georgia Abu-Hayyeh, Shadi Nikolopoulou, Evanthia Briz, Oscar Owen, Bryn M. Nikolova, Vanya Ovadia, Caroline Huang, Xiao Vaarasmaki, Marja Baumann, Marc Jansen, Eugene Albrecht, Christiane Jarvelin, Marjo-Riitta Marin, Jose J. G. Knisely, A. S. Williamson, Catherine Maternal cholestasis during pregnancy programs metabolic disease in offspring |
topic_facet |
610 Medicine & health 570 Life sciences biology |
description |
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland birth cohort 1985-1986 database and found that 16-year-old children of mothers with ICP had altered lipid profiles. Males had increased BMI, and females exhibited increased waist and hip girth compared with the offspring of uncomplicated pregnancies. We further investigated the effect of maternal cholestasis on the metabolism of adult offspring in the mouse. Females from cholestatic mothers developed a severe obese, diabetic phenotype with hepatosteatosis following a Western diet, whereas matched mice not exposed to cholestasis in utero did not. Female littermates were susceptible to metabolic disease before dietary challenge. Human and mouse studies showed an accumulation of lipids in the fetoplacental unit and increased transplacental cholesterol transport in cholestatic pregnancy. We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring. |
format |
Article in Journal/Newspaper |
author |
Papacleovoulou, Georgia Abu-Hayyeh, Shadi Nikolopoulou, Evanthia Briz, Oscar Owen, Bryn M. Nikolova, Vanya Ovadia, Caroline Huang, Xiao Vaarasmaki, Marja Baumann, Marc Jansen, Eugene Albrecht, Christiane Jarvelin, Marjo-Riitta Marin, Jose J. G. Knisely, A. S. Williamson, Catherine |
author_facet |
Papacleovoulou, Georgia Abu-Hayyeh, Shadi Nikolopoulou, Evanthia Briz, Oscar Owen, Bryn M. Nikolova, Vanya Ovadia, Caroline Huang, Xiao Vaarasmaki, Marja Baumann, Marc Jansen, Eugene Albrecht, Christiane Jarvelin, Marjo-Riitta Marin, Jose J. G. Knisely, A. S. Williamson, Catherine |
author_sort |
Papacleovoulou, Georgia |
title |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_short |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_full |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_fullStr |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_full_unstemmed |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_sort |
maternal cholestasis during pregnancy programs metabolic disease in offspring |
publisher |
American Society for Clinical Investigation |
publishDate |
2013 |
url |
https://boris.unibe.ch/43271/1/23934127.pdf https://boris.unibe.ch/43271/ |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Papacleovoulou, Georgia; Abu-Hayyeh, Shadi; Nikolopoulou, Evanthia; Briz, Oscar; Owen, Bryn M.; Nikolova, Vanya; Ovadia, Caroline; Huang, Xiao; Vaarasmaki, Marja; Baumann, Marc; Jansen, Eugene; Albrecht, Christiane; Jarvelin, Marjo-Riitta; Marin, Jose J. G.; Knisely, A. S.; Williamson, Catherine (2013). Maternal cholestasis during pregnancy programs metabolic disease in offspring. Journal of clinical investigation, 123(7), pp. 3172-3181. American Society for Clinical Investigation 10.1172/JCI68927 <http://dx.doi.org/10.1172/JCI68927> |
op_relation |
https://boris.unibe.ch/43271/ |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1172/JCI68927 |
container_title |
Journal of Clinical Investigation |
container_volume |
123 |
container_issue |
7 |
container_start_page |
3172 |
op_container_end_page |
3181 |
_version_ |
1774721152280690688 |