Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dyna...
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ftunivbern:oai:boris.unibe.ch:164216 2024-04-28T08:16:13+00:00 Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations Schmidt, Sabrina Reil, Daniela Jeske, Kathrin Drewes, Stephan Rosenfeld, Ulrike M. Fischer, Stefan Spierling, Nastasja G. Labutin, Anton Heckel, Gerald Jacob, Jens Ulrich, Rainer G. Imholt, Christian 2021-06-11 application/pdf https://boris.unibe.ch/164216/1/viruses-13-01132-v3.pdf https://boris.unibe.ch/164216/ eng eng Molecular Diversity Preservation International MDPI https://boris.unibe.ch/164216/ info:eu-repo/semantics/openAccess Schmidt, Sabrina; Reil, Daniela; Jeske, Kathrin; Drewes, Stephan; Rosenfeld, Ulrike M.; Fischer, Stefan; Spierling, Nastasja G.; Labutin, Anton; Heckel, Gerald; Jacob, Jens; Ulrich, Rainer G.; Imholt, Christian (2021). Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations. Viruses, 13(6), p. 1132. Molecular Diversity Preservation International MDPI 10.3390/v13061132 <http://dx.doi.org/10.3390/v13061132> 570 Life sciences biology info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed 2021 ftunivbern https://doi.org/10.3390/v13061132 2024-04-03T14:10:36Z Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics. Article in Journal/Newspaper Common vole Microtus arvalis BORIS (Bern Open Repository and Information System, University of Bern) Viruses 13 6 1132 |
institution |
Open Polar |
collection |
BORIS (Bern Open Repository and Information System, University of Bern) |
op_collection_id |
ftunivbern |
language |
English |
topic |
570 Life sciences biology |
spellingShingle |
570 Life sciences biology Schmidt, Sabrina Reil, Daniela Jeske, Kathrin Drewes, Stephan Rosenfeld, Ulrike M. Fischer, Stefan Spierling, Nastasja G. Labutin, Anton Heckel, Gerald Jacob, Jens Ulrich, Rainer G. Imholt, Christian Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
topic_facet |
570 Life sciences biology |
description |
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics. |
format |
Article in Journal/Newspaper |
author |
Schmidt, Sabrina Reil, Daniela Jeske, Kathrin Drewes, Stephan Rosenfeld, Ulrike M. Fischer, Stefan Spierling, Nastasja G. Labutin, Anton Heckel, Gerald Jacob, Jens Ulrich, Rainer G. Imholt, Christian |
author_facet |
Schmidt, Sabrina Reil, Daniela Jeske, Kathrin Drewes, Stephan Rosenfeld, Ulrike M. Fischer, Stefan Spierling, Nastasja G. Labutin, Anton Heckel, Gerald Jacob, Jens Ulrich, Rainer G. Imholt, Christian |
author_sort |
Schmidt, Sabrina |
title |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_short |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_full |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_fullStr |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_full_unstemmed |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_sort |
spatial and temporal dynamics and molecular evolution of tula orthohantavirus in german vole populations |
publisher |
Molecular Diversity Preservation International MDPI |
publishDate |
2021 |
url |
https://boris.unibe.ch/164216/1/viruses-13-01132-v3.pdf https://boris.unibe.ch/164216/ |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_source |
Schmidt, Sabrina; Reil, Daniela; Jeske, Kathrin; Drewes, Stephan; Rosenfeld, Ulrike M.; Fischer, Stefan; Spierling, Nastasja G.; Labutin, Anton; Heckel, Gerald; Jacob, Jens; Ulrich, Rainer G.; Imholt, Christian (2021). Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations. Viruses, 13(6), p. 1132. Molecular Diversity Preservation International MDPI 10.3390/v13061132 <http://dx.doi.org/10.3390/v13061132> |
op_relation |
https://boris.unibe.ch/164216/ |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/v13061132 |
container_title |
Viruses |
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13 |
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6 |
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1132 |
_version_ |
1797581390481457152 |