Hantavirus–Leptospira coinfections in small mammals from central Germany
European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the...
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ftunivbern:oai:boris.unibe.ch:164208 2023-08-20T04:07:59+02:00 Hantavirus–Leptospira coinfections in small mammals from central Germany Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. 2021-02-16 application/pdf https://boris.unibe.ch/164208/1/hantavirusleptospira-coinfections-in-small-mammals-from-central-germany.pdf https://boris.unibe.ch/164208/ eng eng Cambridge University Press https://boris.unibe.ch/164208/ info:eu-repo/semantics/openAccess Jeske, K.; Jacob, J.; Drewes, S.; Pfeffer, M.; Heckel, G.; Ulrich, R. G.; Imholt, C. (2021). Hantavirus–Leptospira coinfections in small mammals from central Germany. Epidemiology and infection, 149(e97), pp. 1-10. Cambridge University Press 10.1017/S0950268821000443 <http://dx.doi.org/10.1017/S0950268821000443> 570 Life sciences biology info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed 2021 ftunivbern https://doi.org/10.1017/S0950268821000443 2023-07-31T22:11:18Z European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (Microtus agrestis) with 54.5% (6/11) and common voles (Microtus arvalis) with 30.3% (205/676). Leptospira–hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. Article in Journal/Newspaper Microtus arvalis BORIS (Bern Open Repository and Information System, University of Bern) Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Epidemiology and Infection 149 |
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BORIS (Bern Open Repository and Information System, University of Bern) |
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ftunivbern |
language |
English |
topic |
570 Life sciences biology |
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570 Life sciences biology Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. Hantavirus–Leptospira coinfections in small mammals from central Germany |
topic_facet |
570 Life sciences biology |
description |
European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (Microtus agrestis) with 54.5% (6/11) and common voles (Microtus arvalis) with 30.3% (205/676). Leptospira–hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. |
format |
Article in Journal/Newspaper |
author |
Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. |
author_facet |
Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. |
author_sort |
Jeske, K. |
title |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_short |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_full |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_fullStr |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_full_unstemmed |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_sort |
hantavirus–leptospira coinfections in small mammals from central germany |
publisher |
Cambridge University Press |
publishDate |
2021 |
url |
https://boris.unibe.ch/164208/1/hantavirusleptospira-coinfections-in-small-mammals-from-central-germany.pdf https://boris.unibe.ch/164208/ |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Jeske, K.; Jacob, J.; Drewes, S.; Pfeffer, M.; Heckel, G.; Ulrich, R. G.; Imholt, C. (2021). Hantavirus–Leptospira coinfections in small mammals from central Germany. Epidemiology and infection, 149(e97), pp. 1-10. Cambridge University Press 10.1017/S0950268821000443 <http://dx.doi.org/10.1017/S0950268821000443> |
op_relation |
https://boris.unibe.ch/164208/ |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1017/S0950268821000443 |
container_title |
Epidemiology and Infection |
container_volume |
149 |
_version_ |
1774719991275323392 |