Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss.
Intestinal adenocarcinomas are uncommon in fishes. To date, they have been reported in zebrafish Danio rerio, blue gularis Fundulopanchax sjostedti, koi carp Cyprinus carpio koi, Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Metastases are even rarer and have been observed so fa...
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Online Access: | https://boris.unibe.ch/159275/1/Gombac2021_Intestinal_adenocarcinoma_in_trout_DisAquatOrg.pdf https://boris.unibe.ch/159275/ |
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ftunivbern:oai:boris.unibe.ch:159275 2023-08-20T04:05:19+02:00 Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik Flajs, Vesna Schmidt-Posthaus, Heike 2021-05-27 application/pdf https://boris.unibe.ch/159275/1/Gombac2021_Intestinal_adenocarcinoma_in_trout_DisAquatOrg.pdf https://boris.unibe.ch/159275/ eng eng Inter-Research https://boris.unibe.ch/159275/ info:eu-repo/semantics/restrictedAccess Gombač, Mitja; Seničar, Marija; Švara, Tanja; Šturm, Sabina; Dolenšek, Tamara; Tekavec, Kristina; Cerkvenik Flajs, Vesna; Schmidt-Posthaus, Heike (2021). Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. Diseases of aquatic organisms, 144, pp. 237-244. Inter-Research 10.3354/dao03592 <http://dx.doi.org/10.3354/dao03592> 500 Science 570 Life sciences biology 590 Animals (Zoology) 610 Medicine & health 630 Agriculture info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed 2021 ftunivbern https://doi.org/10.3354/dao03592 2023-07-31T22:08:35Z Intestinal adenocarcinomas are uncommon in fishes. To date, they have been reported in zebrafish Danio rerio, blue gularis Fundulopanchax sjostedti, koi carp Cyprinus carpio koi, Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Metastases are even rarer and have been observed so far at very low prevalence, only in feed-induced adenocarcinoma in Atlantic salmon and rainbow trout. Intestinal adenocarcinoma with liver and heart metastases and mesenteric invasion was found in approximately 33% of 4 yr old rainbow trout from a Slovene hatchery with 2000 breeding trout. During stripping, lumps in the abdominal cavity were palpated in one-third of the breeding fish; some of the fish were anorectic and lethargic, and mortality was slightly increased. Affected trout were euthanized and 4 were submitted for necropsy and histopathology. Necropsy revealed firm, whitish, irregularly lobular masses originating from the intestine. Histologically, the intestinal masses showed a prominent proliferation of tall columnar neoplastic epithelial cells arranged in dense irregular islands or solid areas and papillotubular protuberances. Solid areas of neoplastic cells were also observed in the mesentery of all trout and in the liver of one trout, whereas minute groups of neoplastic cells were seen in the vessels of the intestinal mucosa in all trout and in the myocardium and the liver of one trout. Epithelial origin of neoplastic cells was confirmed by expression of the cytokeratin marker AE1/AE3. The intestinal masses were diagnosed as intestinal adenocarcinoma with mesenteric invasion and metastases to the liver and heart. The cause of intestinal adenocarcinoma was not determined. Article in Journal/Newspaper Atlantic salmon Salmo salar BORIS (Bern Open Repository and Information System, University of Bern) Diseases of Aquatic Organisms 144 237 244 |
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Open Polar |
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BORIS (Bern Open Repository and Information System, University of Bern) |
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ftunivbern |
language |
English |
topic |
500 Science 570 Life sciences biology 590 Animals (Zoology) 610 Medicine & health 630 Agriculture |
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500 Science 570 Life sciences biology 590 Animals (Zoology) 610 Medicine & health 630 Agriculture Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik Flajs, Vesna Schmidt-Posthaus, Heike Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. |
topic_facet |
500 Science 570 Life sciences biology 590 Animals (Zoology) 610 Medicine & health 630 Agriculture |
description |
Intestinal adenocarcinomas are uncommon in fishes. To date, they have been reported in zebrafish Danio rerio, blue gularis Fundulopanchax sjostedti, koi carp Cyprinus carpio koi, Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Metastases are even rarer and have been observed so far at very low prevalence, only in feed-induced adenocarcinoma in Atlantic salmon and rainbow trout. Intestinal adenocarcinoma with liver and heart metastases and mesenteric invasion was found in approximately 33% of 4 yr old rainbow trout from a Slovene hatchery with 2000 breeding trout. During stripping, lumps in the abdominal cavity were palpated in one-third of the breeding fish; some of the fish were anorectic and lethargic, and mortality was slightly increased. Affected trout were euthanized and 4 were submitted for necropsy and histopathology. Necropsy revealed firm, whitish, irregularly lobular masses originating from the intestine. Histologically, the intestinal masses showed a prominent proliferation of tall columnar neoplastic epithelial cells arranged in dense irregular islands or solid areas and papillotubular protuberances. Solid areas of neoplastic cells were also observed in the mesentery of all trout and in the liver of one trout, whereas minute groups of neoplastic cells were seen in the vessels of the intestinal mucosa in all trout and in the myocardium and the liver of one trout. Epithelial origin of neoplastic cells was confirmed by expression of the cytokeratin marker AE1/AE3. The intestinal masses were diagnosed as intestinal adenocarcinoma with mesenteric invasion and metastases to the liver and heart. The cause of intestinal adenocarcinoma was not determined. |
format |
Article in Journal/Newspaper |
author |
Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik Flajs, Vesna Schmidt-Posthaus, Heike |
author_facet |
Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik Flajs, Vesna Schmidt-Posthaus, Heike |
author_sort |
Gombač, Mitja |
title |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. |
title_short |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. |
title_full |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. |
title_fullStr |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. |
title_full_unstemmed |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. |
title_sort |
sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout oncorhynchus mykiss. |
publisher |
Inter-Research |
publishDate |
2021 |
url |
https://boris.unibe.ch/159275/1/Gombac2021_Intestinal_adenocarcinoma_in_trout_DisAquatOrg.pdf https://boris.unibe.ch/159275/ |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Gombač, Mitja; Seničar, Marija; Švara, Tanja; Šturm, Sabina; Dolenšek, Tamara; Tekavec, Kristina; Cerkvenik Flajs, Vesna; Schmidt-Posthaus, Heike (2021). Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss. Diseases of aquatic organisms, 144, pp. 237-244. Inter-Research 10.3354/dao03592 <http://dx.doi.org/10.3354/dao03592> |
op_relation |
https://boris.unibe.ch/159275/ |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.3354/dao03592 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
144 |
container_start_page |
237 |
op_container_end_page |
244 |
_version_ |
1774715802778337280 |