Molecular visualization of cellular complexity.
Structural biology has paved the way for a ground-up description of biological systems, contributing atomic structures of proteins amenable to crystallography, uncovering high-resolution maps of ‘difficult’ proteins with the cryo-electron microscopy revolution, and filling knowledge gaps regarding d...
| Published in: | Nature Methods |
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| Main Authors: | , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Springer Nature
2021
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| Subjects: | |
| Online Access: | https://boris.unibe.ch/158330/1/wwPDB_biocuration__on_the_front_line_of_structural_biology.pdf https://boris.unibe.ch/158330/8/EMS129542.pdf https://boris.unibe.ch/158330/ |
| Summary: | Structural biology has paved the way for a ground-up description of biological systems, contributing atomic structures of proteins amenable to crystallography, uncovering high-resolution maps of ‘difficult’ proteins with the cryo-electron microscopy revolution, and filling knowledge gaps regarding dynamic and disordered proteins using nuclear magnetic resonance. From the very beginning, the cellular context of a protein of interest was considered; John Kendrew chose sperm whale myoglobin for crystallization because of myoglobin’s importance and abundance within the dark red tissues of diving animals and thereby solved the first three-dimensional protein structure1. Together, cell and structural biology work synergistically towards a common goal: to build a mechanistic description of biological systems. |
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