Patterns of homozygosity in insular and continental goat breeds.
BACKGROUND Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds...
Published in: | Genetics Selection Evolution |
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ftunivbern:oai:boris.unibe.ch:127323 2023-08-20T04:07:25+02:00 Patterns of homozygosity in insular and continental goat breeds. Cardoso, Taina F Amills, Marcel Bertolini, Francesca Rothschild, Max Marras, Gabriele Boink, Geert Jordana, Jordi Capote, Juan Carolan, Sean Hallsson, Jón H Kantanen, Juha Pons, Agueda Lenstra, Johannes A AdaptMap, Consortium 2018-11-19 application/pdf https://boris.unibe.ch/127323/1/Cardoso%20et%20al%20GSE%202018.pdf https://boris.unibe.ch/127323/ eng eng BioMed Central https://boris.unibe.ch/127323/ info:eu-repo/semantics/openAccess Cardoso, Taina F; Amills, Marcel; Bertolini, Francesca; Rothschild, Max; Marras, Gabriele; Boink, Geert; Jordana, Jordi; Capote, Juan; Carolan, Sean; Hallsson, Jón H; Kantanen, Juha; Pons, Agueda; Lenstra, Johannes A; AdaptMap, Consortium (2018). Patterns of homozygosity in insular and continental goat breeds. Genetics, selection, evolution, 50(1), p. 56. BioMed Central 10.1186/s12711-018-0425-7 <http://dx.doi.org/10.1186/s12711-018-0425-7> 590 Animals (Zoology) 630 Agriculture info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed 2018 ftunivbern https://doi.org/10.1186/s12711-018-0425-7 2023-07-31T21:50:33Z BACKGROUND Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds. RESULTS Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1.6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and F values (P value < 0.05). Goats from Mediterranean islands represent a more complex case because certain populations displayed a significantly increased level of homozygosity (e.g. Girgentana) and others did not (e.g. Corse and Sarda). Correlations of number and total length of ROH for insular goat populations with the distance between islands and the nearest continental locations revealed an effect of extremely long distances on the patterns of homozygosity. CONCLUSIONS These results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management. Article in Journal/Newspaper Iceland BORIS (Bern Open Repository and Information System, University of Bern) Genetics Selection Evolution 50 1 |
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Open Polar |
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BORIS (Bern Open Repository and Information System, University of Bern) |
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ftunivbern |
language |
English |
topic |
590 Animals (Zoology) 630 Agriculture |
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590 Animals (Zoology) 630 Agriculture Cardoso, Taina F Amills, Marcel Bertolini, Francesca Rothschild, Max Marras, Gabriele Boink, Geert Jordana, Jordi Capote, Juan Carolan, Sean Hallsson, Jón H Kantanen, Juha Pons, Agueda Lenstra, Johannes A AdaptMap, Consortium Patterns of homozygosity in insular and continental goat breeds. |
topic_facet |
590 Animals (Zoology) 630 Agriculture |
description |
BACKGROUND Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds. RESULTS Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1.6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and F values (P value < 0.05). Goats from Mediterranean islands represent a more complex case because certain populations displayed a significantly increased level of homozygosity (e.g. Girgentana) and others did not (e.g. Corse and Sarda). Correlations of number and total length of ROH for insular goat populations with the distance between islands and the nearest continental locations revealed an effect of extremely long distances on the patterns of homozygosity. CONCLUSIONS These results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management. |
format |
Article in Journal/Newspaper |
author |
Cardoso, Taina F Amills, Marcel Bertolini, Francesca Rothschild, Max Marras, Gabriele Boink, Geert Jordana, Jordi Capote, Juan Carolan, Sean Hallsson, Jón H Kantanen, Juha Pons, Agueda Lenstra, Johannes A AdaptMap, Consortium |
author_facet |
Cardoso, Taina F Amills, Marcel Bertolini, Francesca Rothschild, Max Marras, Gabriele Boink, Geert Jordana, Jordi Capote, Juan Carolan, Sean Hallsson, Jón H Kantanen, Juha Pons, Agueda Lenstra, Johannes A AdaptMap, Consortium |
author_sort |
Cardoso, Taina F |
title |
Patterns of homozygosity in insular and continental goat breeds. |
title_short |
Patterns of homozygosity in insular and continental goat breeds. |
title_full |
Patterns of homozygosity in insular and continental goat breeds. |
title_fullStr |
Patterns of homozygosity in insular and continental goat breeds. |
title_full_unstemmed |
Patterns of homozygosity in insular and continental goat breeds. |
title_sort |
patterns of homozygosity in insular and continental goat breeds. |
publisher |
BioMed Central |
publishDate |
2018 |
url |
https://boris.unibe.ch/127323/1/Cardoso%20et%20al%20GSE%202018.pdf https://boris.unibe.ch/127323/ |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cardoso, Taina F; Amills, Marcel; Bertolini, Francesca; Rothschild, Max; Marras, Gabriele; Boink, Geert; Jordana, Jordi; Capote, Juan; Carolan, Sean; Hallsson, Jón H; Kantanen, Juha; Pons, Agueda; Lenstra, Johannes A; AdaptMap, Consortium (2018). Patterns of homozygosity in insular and continental goat breeds. Genetics, selection, evolution, 50(1), p. 56. BioMed Central 10.1186/s12711-018-0425-7 <http://dx.doi.org/10.1186/s12711-018-0425-7> |
op_relation |
https://boris.unibe.ch/127323/ |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s12711-018-0425-7 |
container_title |
Genetics Selection Evolution |
container_volume |
50 |
container_issue |
1 |
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1774719033087623168 |