High genetic structuring of Tula hantavirus
Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT...
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ftunivbern:oai:boris.unibe.ch:118940 2023-08-20T04:05:58+02:00 High genetic structuring of Tula hantavirus Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana A. Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer G. 2016-01-30 application/pdf https://boris.unibe.ch/118940/1/Schmidt2016_Article_HighGeneticStructuringOfTulaHa.pdf https://boris.unibe.ch/118940/ eng eng Springer https://boris.unibe.ch/118940/ info:eu-repo/semantics/openAccess Schmidt, Sabrina; Saxenhofer, Moritz; Drewes, Stephan; Schlegel, Mathias; Wanka, Konrad M.; Frank, Raphael; Klimpel, Sven; von Blanckenhagen, Felix; Maaz, Denny; Herden, Christiane; Freise, Jona; Wolf, Ronny; Stubbe, Michael; Borkenhagen, Peter; Ansorge, Hermann; Eccard, Jana A.; Lang, Johannes; Jourdain, Elsa; Jacob, Jens; Marianneau, Philippe; . (2016). High genetic structuring of Tula hantavirus. Archives of virology, 161(5), pp. 1135-1149. Springer 10.1007/s00705-016-2762-6 <http://dx.doi.org/10.1007/s00705-016-2762-6> 570 Life sciences biology info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed 2016 ftunivbern https://doi.org/10.1007/s00705-016-2762-6 2023-07-31T21:45:46Z Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas. Article in Journal/Newspaper Common vole Microtus arvalis BORIS (Bern Open Repository and Information System, University of Bern) Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Archives of Virology 161 5 1135 1149 |
institution |
Open Polar |
collection |
BORIS (Bern Open Repository and Information System, University of Bern) |
op_collection_id |
ftunivbern |
language |
English |
topic |
570 Life sciences biology |
spellingShingle |
570 Life sciences biology Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana A. Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer G. High genetic structuring of Tula hantavirus |
topic_facet |
570 Life sciences biology |
description |
Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas. |
format |
Article in Journal/Newspaper |
author |
Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana A. Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer G. |
author_facet |
Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana A. Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer G. |
author_sort |
Schmidt, Sabrina |
title |
High genetic structuring of Tula hantavirus |
title_short |
High genetic structuring of Tula hantavirus |
title_full |
High genetic structuring of Tula hantavirus |
title_fullStr |
High genetic structuring of Tula hantavirus |
title_full_unstemmed |
High genetic structuring of Tula hantavirus |
title_sort |
high genetic structuring of tula hantavirus |
publisher |
Springer |
publishDate |
2016 |
url |
https://boris.unibe.ch/118940/1/Schmidt2016_Article_HighGeneticStructuringOfTulaHa.pdf https://boris.unibe.ch/118940/ |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_source |
Schmidt, Sabrina; Saxenhofer, Moritz; Drewes, Stephan; Schlegel, Mathias; Wanka, Konrad M.; Frank, Raphael; Klimpel, Sven; von Blanckenhagen, Felix; Maaz, Denny; Herden, Christiane; Freise, Jona; Wolf, Ronny; Stubbe, Michael; Borkenhagen, Peter; Ansorge, Hermann; Eccard, Jana A.; Lang, Johannes; Jourdain, Elsa; Jacob, Jens; Marianneau, Philippe; . (2016). High genetic structuring of Tula hantavirus. Archives of virology, 161(5), pp. 1135-1149. Springer 10.1007/s00705-016-2762-6 <http://dx.doi.org/10.1007/s00705-016-2762-6> |
op_relation |
https://boris.unibe.ch/118940/ |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s00705-016-2762-6 |
container_title |
Archives of Virology |
container_volume |
161 |
container_issue |
5 |
container_start_page |
1135 |
op_container_end_page |
1149 |
_version_ |
1774716807698972672 |