Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids
Marine resources are today limited, and due to this there is an increasing inclusion of non-marine lipids in the diet of farmed salmonids. An optimal diet for farmed Atlantic salmon (Salmo salar L.) should not only promote fast growth, but also keep the fish at good health, making it robust to face...
Published in: | Aquaculture Nutrition |
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Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
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The University of Bergen
2014
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Online Access: | http://hdl.handle.net/1956/9406 |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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English |
description |
Marine resources are today limited, and due to this there is an increasing inclusion of non-marine lipids in the diet of farmed salmonids. An optimal diet for farmed Atlantic salmon (Salmo salar L.) should not only promote fast growth, but also keep the fish at good health, making it robust to face changes and stressors from the surrounding environment. There is, however, still knowledge lacking about the nutritional needs of Atlantic salmon. Lipid sources vary in their fatty acid (FA) composition, as well as in content of other lipid soluble compounds, such as sterols and environmental contaminants. The focus of this thesis has been to study the effect of FAs and lipid soluble compounds on Atlantic salmon lipid metabolism and metabolic health. Very long-chained n-3 polyunsaturated fatty acids (VLC n-3 PUFAs), typically found in the marine environment, have on several occasions shown to have lipid-lowering properties. The lower dietary and tissue concentrations of these FAs in Atlantic salmon due to the substitution of marine oils with terrestrial oils, may thus have effects on the lipid metabolism. This was studied by performing four dietary trials using feeds with low concentrations of marine oils (0 – 86 g marine oils kg-1 feed), and thus also low dietary concentrations of VLC n-3 PUFAs (1.5 - 8.5 % eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) of total FAs and 0.5 – 6.6 % of diet). Lower dietary concentrations of VLC n-3 PUFAs tended to increase liver lipids in all the dietary trials. However, the observed changes in liver lipid content could not solely be explained by dietary concentrations of VLC n-3 PUFAs. Thus, dietary concentrations of saturated fats or plant sterols, commonly known as phytosterols, are hypothesised to affect liver lipid stores. Phytosterols are well-known to lower the uptake and synthesis of cholesterol, and might therefore have caused a cholesterol deficiency in the fish fed the low-marine diets containing low cholesterol levels. The transcription factors affected by ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Liland, Nina Sylvia |
spellingShingle |
Liland, Nina Sylvia Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids |
author_facet |
Liland, Nina Sylvia |
author_sort |
Liland, Nina Sylvia |
title |
Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids |
title_short |
Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids |
title_full |
Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids |
title_fullStr |
Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids |
title_full_unstemmed |
Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids |
title_sort |
atlantic salmon (salmo salar l.) sterol metabolism and metabolic health – impact of dietary lipids |
publisher |
The University of Bergen |
publishDate |
2014 |
url |
http://hdl.handle.net/1956/9406 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Paper I: Liland, N.S., Rosenlund, G., Berntssen, M.H.G, Brattelid, T., Madsen, L. & Torstensen, B.E. (2013a): “Net production of Atlantic salmon (FIFO, Fish in Fish out < 1) with dietary plant proteins and vegetable oils”, Aquaculture Nutrition, Vol. 19: 289-300. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1111/j.1365-2095.2012.00958.x . Paper II: Liland, N.S., Espe, M., Rosenlund, G., Waagbø, R., Hjelle, J. I., Lie, Ø., Fontanillas, R. & Torstensen, B. E. (2013b): “High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.)”, British Journal of Nutrition, Vol. 110: 1958–1967. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1017/S0007114513001347 . Paper III: Liland, N.S., Hatlen, B., Takle, H., Venegas, C., Espe, M., Torstensen, B. E. & Waagbø, R. (2014): “Including processed poultry and porcine by-products in diets high in plant ingredients reduced liver TAG in Atlantic salmon, Salmo salar L.”, Aquaculture Nutrition. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1111/anu.12190 . Paper IV: Liland, N.S., Rocha, S., Pittman, K., Campo, A., Holen, E., Torstensen, B. E., Rosenlund, G. & Sissener, N. H.: “Dietary EPA and DHA and water temperature affect inflammation but not visceral adipose tissue in Atlantic salmon (Salmo salar L.)”. Full text not available in BORA. Paper V: Liland, N. S., Simonsen, A. C., Duelund, L., Torstensen, B. E., Berntssen, M. G. & Mouritsen, O. G. (2014): “Polyaromatic hydrocarbons do not disturb liquid-liquid phase coexistence, but increase the fluidity of model membranes”, Chemistry and Physics of Lipids, Vol. 184: 18-24. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1016/j.chemphyslip.2014.08.004 . urn:isbn:978-82-308-2754-3 http://hdl.handle.net/1956/9406 cristin:1199192 |
op_rights |
Copyright the author. All rights reserved |
container_title |
Aquaculture Nutrition |
container_volume |
19 |
container_issue |
3 |
container_start_page |
289 |
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300 |
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ftunivbergen:oai:bora.uib.no:1956/9406 2023-05-15T15:30:15+02:00 Atlantic salmon (Salmo salar L.) sterol metabolism and metabolic health – impact of dietary lipids Liland, Nina Sylvia 2014-12-12 application/pdf http://hdl.handle.net/1956/9406 eng eng The University of Bergen Paper I: Liland, N.S., Rosenlund, G., Berntssen, M.H.G, Brattelid, T., Madsen, L. & Torstensen, B.E. (2013a): “Net production of Atlantic salmon (FIFO, Fish in Fish out < 1) with dietary plant proteins and vegetable oils”, Aquaculture Nutrition, Vol. 19: 289-300. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1111/j.1365-2095.2012.00958.x . Paper II: Liland, N.S., Espe, M., Rosenlund, G., Waagbø, R., Hjelle, J. I., Lie, Ø., Fontanillas, R. & Torstensen, B. E. (2013b): “High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.)”, British Journal of Nutrition, Vol. 110: 1958–1967. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1017/S0007114513001347 . Paper III: Liland, N.S., Hatlen, B., Takle, H., Venegas, C., Espe, M., Torstensen, B. E. & Waagbø, R. (2014): “Including processed poultry and porcine by-products in diets high in plant ingredients reduced liver TAG in Atlantic salmon, Salmo salar L.”, Aquaculture Nutrition. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1111/anu.12190 . Paper IV: Liland, N.S., Rocha, S., Pittman, K., Campo, A., Holen, E., Torstensen, B. E., Rosenlund, G. & Sissener, N. H.: “Dietary EPA and DHA and water temperature affect inflammation but not visceral adipose tissue in Atlantic salmon (Salmo salar L.)”. Full text not available in BORA. Paper V: Liland, N. S., Simonsen, A. C., Duelund, L., Torstensen, B. E., Berntssen, M. G. & Mouritsen, O. G. (2014): “Polyaromatic hydrocarbons do not disturb liquid-liquid phase coexistence, but increase the fluidity of model membranes”, Chemistry and Physics of Lipids, Vol. 184: 18-24. Full text not available in BORA due to publisher restrictions. The article is available at: http://dx.doi.org/10.1016/j.chemphyslip.2014.08.004 . urn:isbn:978-82-308-2754-3 http://hdl.handle.net/1956/9406 cristin:1199192 Copyright the author. All rights reserved Doctoral thesis 2014 ftunivbergen 2023-03-14T17:43:13Z Marine resources are today limited, and due to this there is an increasing inclusion of non-marine lipids in the diet of farmed salmonids. An optimal diet for farmed Atlantic salmon (Salmo salar L.) should not only promote fast growth, but also keep the fish at good health, making it robust to face changes and stressors from the surrounding environment. There is, however, still knowledge lacking about the nutritional needs of Atlantic salmon. Lipid sources vary in their fatty acid (FA) composition, as well as in content of other lipid soluble compounds, such as sterols and environmental contaminants. The focus of this thesis has been to study the effect of FAs and lipid soluble compounds on Atlantic salmon lipid metabolism and metabolic health. Very long-chained n-3 polyunsaturated fatty acids (VLC n-3 PUFAs), typically found in the marine environment, have on several occasions shown to have lipid-lowering properties. The lower dietary and tissue concentrations of these FAs in Atlantic salmon due to the substitution of marine oils with terrestrial oils, may thus have effects on the lipid metabolism. This was studied by performing four dietary trials using feeds with low concentrations of marine oils (0 – 86 g marine oils kg-1 feed), and thus also low dietary concentrations of VLC n-3 PUFAs (1.5 - 8.5 % eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) of total FAs and 0.5 – 6.6 % of diet). Lower dietary concentrations of VLC n-3 PUFAs tended to increase liver lipids in all the dietary trials. However, the observed changes in liver lipid content could not solely be explained by dietary concentrations of VLC n-3 PUFAs. Thus, dietary concentrations of saturated fats or plant sterols, commonly known as phytosterols, are hypothesised to affect liver lipid stores. Phytosterols are well-known to lower the uptake and synthesis of cholesterol, and might therefore have caused a cholesterol deficiency in the fish fed the low-marine diets containing low cholesterol levels. The transcription factors affected by ... Doctoral or Postdoctoral Thesis Atlantic salmon Salmo salar University of Bergen: Bergen Open Research Archive (BORA-UiB) Aquaculture Nutrition 19 3 289 300 |