Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995
In 50–79-year-olds who participated in the Tromsø Study (1994–1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50–64 years. Introduction We aimed...
Published in: | Osteoporosis International |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/1956/22589 https://doi.org/10.1007/s00198-019-05191-4 |
id |
ftunivbergen:oai:bora.uib.no:1956/22589 |
---|---|
record_format |
openpolar |
spelling |
ftunivbergen:oai:bora.uib.no:1956/22589 2023-05-15T17:39:25+02:00 Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 Søgaard, Anne-Johanne Magnus, Jeanette H. Bjørnerem, Åshild Holvik, Kristin Ranhoff, Anette Hylen Emaus, Nina Meyer, Haakon E Strand, Bjørn Heine 2019-10-30T14:57:32Z application/pdf https://hdl.handle.net/1956/22589 https://doi.org/10.1007/s00198-019-05191-4 eng eng Springer urn:issn:1433-2965 urn:issn:0937-941X https://hdl.handle.net/1956/22589 https://doi.org/10.1007/s00198-019-05191-4 cristin:1742301 Osteoporosis International. 2020;31:131-140 Copyright International Osteoporosis Foundation and National Osteoporosis Foundation 2019 Osteoporosis International 131-140 31 Peer reviewed Journal article 2019 ftunivbergen https://doi.org/10.1007/s00198-019-05191-4 2023-03-14T17:39:02Z In 50–79-year-olds who participated in the Tromsø Study (1994–1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50–64 years. Introduction We aimed to explore whether low grip strength was associated with increased risk of non-vertebral osteoporotic fracture in the population-based Tromsø Study 1994–1995. Methods Grip strength (bar) was measured by a Martin Vigorimeter and fractures were retrieved from the X-ray archives at the University Hospital of North Norway between 1994 and 2010. At baseline, weight and height were measured, whereas information on the other covariates were obtained through self-reported questionnaires. Cox regression was used to estimate the hazard ratio (HR) of fracture in age- and gender-specific quintiles of grip-strength, and per 1 SD lower grip strength. Similar analyses were done solely for hip fractures. Adjustments were made for age, height, body mass index (BMI), marital status, education, smoking, physical activity, use of alcohol, self-perceived health, and self-reported diseases. Results In 2891 men and 4002 women aged 50–79 years, 1099 non-vertebral osteoporotic fractures—including 393 hip fractures—were sustained during the median 15 years follow-up. Risk of non-vertebral osteoporotic fracture increased with declining grip strength: hazard ratios per SD decline was 1.22 (95% CI 1.05–1.43) in men and 1.09 (95% CI 1.01–1.18) in women. HR for fracture in lower vs. upper quintile was 1.58 (95% CI 1.02–2.45) in men and 1.28 (95% CI 1.03–1.59) in women. The association was most pronounced in men aged 50–64 years with HR = 3.39 (95% CI 1.76–6.53) in the lower compared to the upper quintile. Conclusions The risk of non-vertebral osteoporotic fracture increased with declining grip-strength in both genders, particularly in men aged 50–64 years. acceptedVersion Article in Journal/Newspaper North Norway Tromsø University of Bergen: Bergen Open Research Archive (BORA-UiB) Norway Tromsø Osteoporosis International 31 1 131 140 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
description |
In 50–79-year-olds who participated in the Tromsø Study (1994–1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50–64 years. Introduction We aimed to explore whether low grip strength was associated with increased risk of non-vertebral osteoporotic fracture in the population-based Tromsø Study 1994–1995. Methods Grip strength (bar) was measured by a Martin Vigorimeter and fractures were retrieved from the X-ray archives at the University Hospital of North Norway between 1994 and 2010. At baseline, weight and height were measured, whereas information on the other covariates were obtained through self-reported questionnaires. Cox regression was used to estimate the hazard ratio (HR) of fracture in age- and gender-specific quintiles of grip-strength, and per 1 SD lower grip strength. Similar analyses were done solely for hip fractures. Adjustments were made for age, height, body mass index (BMI), marital status, education, smoking, physical activity, use of alcohol, self-perceived health, and self-reported diseases. Results In 2891 men and 4002 women aged 50–79 years, 1099 non-vertebral osteoporotic fractures—including 393 hip fractures—were sustained during the median 15 years follow-up. Risk of non-vertebral osteoporotic fracture increased with declining grip strength: hazard ratios per SD decline was 1.22 (95% CI 1.05–1.43) in men and 1.09 (95% CI 1.01–1.18) in women. HR for fracture in lower vs. upper quintile was 1.58 (95% CI 1.02–2.45) in men and 1.28 (95% CI 1.03–1.59) in women. The association was most pronounced in men aged 50–64 years with HR = 3.39 (95% CI 1.76–6.53) in the lower compared to the upper quintile. Conclusions The risk of non-vertebral osteoporotic fracture increased with declining grip-strength in both genders, particularly in men aged 50–64 years. acceptedVersion |
format |
Article in Journal/Newspaper |
author |
Søgaard, Anne-Johanne Magnus, Jeanette H. Bjørnerem, Åshild Holvik, Kristin Ranhoff, Anette Hylen Emaus, Nina Meyer, Haakon E Strand, Bjørn Heine |
spellingShingle |
Søgaard, Anne-Johanne Magnus, Jeanette H. Bjørnerem, Åshild Holvik, Kristin Ranhoff, Anette Hylen Emaus, Nina Meyer, Haakon E Strand, Bjørn Heine Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 |
author_facet |
Søgaard, Anne-Johanne Magnus, Jeanette H. Bjørnerem, Åshild Holvik, Kristin Ranhoff, Anette Hylen Emaus, Nina Meyer, Haakon E Strand, Bjørn Heine |
author_sort |
Søgaard, Anne-Johanne |
title |
Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 |
title_short |
Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 |
title_full |
Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 |
title_fullStr |
Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 |
title_full_unstemmed |
Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 |
title_sort |
grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: the tromsø study 1994–1995 |
publisher |
Springer |
publishDate |
2019 |
url |
https://hdl.handle.net/1956/22589 https://doi.org/10.1007/s00198-019-05191-4 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
North Norway Tromsø |
genre_facet |
North Norway Tromsø |
op_source |
Osteoporosis International 131-140 31 |
op_relation |
urn:issn:1433-2965 urn:issn:0937-941X https://hdl.handle.net/1956/22589 https://doi.org/10.1007/s00198-019-05191-4 cristin:1742301 Osteoporosis International. 2020;31:131-140 |
op_rights |
Copyright International Osteoporosis Foundation and National Osteoporosis Foundation 2019 |
op_doi |
https://doi.org/10.1007/s00198-019-05191-4 |
container_title |
Osteoporosis International |
container_volume |
31 |
container_issue |
1 |
container_start_page |
131 |
op_container_end_page |
140 |
_version_ |
1766140182383296512 |