A teleost structural analogue to the avian bursa of Fabricius
The bursa of Fabricius is a primary and secondary lymphoid organ considered exclusively present in birds, and studies of this structure have been vital to our current understanding of the adaptive immune system of vertebrates. In this study, we reveal substantial lymphoepithelial tissue in a previou...
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Online Access: | http://hdl.handle.net/1956/22021 https://doi.org/10.1111/joa.13147 |
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ftunivbergen:oai:bora.uib.no:1956/22021 2023-05-15T15:31:03+02:00 A teleost structural analogue to the avian bursa of Fabricius Løken, Oskar Mongstad Bjørgen, Håvard Hordvik, Ivar Koppang, Erling Olaf 2020-01-31T14:40:50Z application/pdf http://hdl.handle.net/1956/22021 https://doi.org/10.1111/joa.13147 eng eng John Wiley & Sons Ltd. urn:issn:0021-8782 urn:issn:1469-7580 http://hdl.handle.net/1956/22021 https://doi.org/10.1111/joa.13147 cristin:1784651 Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright 2019 The Authors Journal of Anatomy adaptive immune system bursa of Fabricius evolutionary morphology lymphoepithelium lymphoid organs Peer reviewed Journal article 2020 ftunivbergen https://doi.org/10.1111/joa.13147 2023-03-14T17:40:27Z The bursa of Fabricius is a primary and secondary lymphoid organ considered exclusively present in birds, and studies of this structure have been vital to our current understanding of the adaptive immune system of vertebrates. In this study, we reveal substantial lymphoepithelial tissue in a previously undescribed bursa in Atlantic salmon (Salmo salar), situated caudal to the urogenital papilla of the cloaca and thus analogous to the anatomical placement of the bursa of Fabricius. We investigated three groups of Atlantic salmon at different maturational stages and characterized the structure by applying dissection, radiology, scanning electron microscopy and histological techniques, including immunohistochemistry and in situ hybridization. We found that the epithelial anlage of the salmon cloacal bursa developed into substantial lymphoepithelial tissue and subsequently regressed following sexual maturation. Such a dynamic development is also a key characteristic of the avian bursa. The presence of intraepithelial lymphocytes was concomitant with expression of the leukocyte‐attracting chemokine CCL19, indicative of lymphoid organ functions. We did not observe recombination or gene conversion in salmon bursal lymphocytes at any developmental stage, indicating the absence of primary lymphoid organ functions in contrast to the bursa of Fabricius. However, the possibility of the bursa to trap both enteric and environmental antigens, combined with the presence of several antigen‐presenting cells residing within the lymphoepithelium, suggest the structure has secondary lymphoid organ functions. We present the discovery of a lymphoid organ in Atlantic salmon with striking topographical similarities to that of the bursa of Fabricius in birds. In addition, the age‐dependent dynamics of its lymphoepithelium suggest functions related to the maturation processes of lymphocytes. publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar University of Bergen: Bergen Open Research Archive (BORA-UiB) Journal of Anatomy 236 5 798 808 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
topic |
adaptive immune system bursa of Fabricius evolutionary morphology lymphoepithelium lymphoid organs |
spellingShingle |
adaptive immune system bursa of Fabricius evolutionary morphology lymphoepithelium lymphoid organs Løken, Oskar Mongstad Bjørgen, Håvard Hordvik, Ivar Koppang, Erling Olaf A teleost structural analogue to the avian bursa of Fabricius |
topic_facet |
adaptive immune system bursa of Fabricius evolutionary morphology lymphoepithelium lymphoid organs |
description |
The bursa of Fabricius is a primary and secondary lymphoid organ considered exclusively present in birds, and studies of this structure have been vital to our current understanding of the adaptive immune system of vertebrates. In this study, we reveal substantial lymphoepithelial tissue in a previously undescribed bursa in Atlantic salmon (Salmo salar), situated caudal to the urogenital papilla of the cloaca and thus analogous to the anatomical placement of the bursa of Fabricius. We investigated three groups of Atlantic salmon at different maturational stages and characterized the structure by applying dissection, radiology, scanning electron microscopy and histological techniques, including immunohistochemistry and in situ hybridization. We found that the epithelial anlage of the salmon cloacal bursa developed into substantial lymphoepithelial tissue and subsequently regressed following sexual maturation. Such a dynamic development is also a key characteristic of the avian bursa. The presence of intraepithelial lymphocytes was concomitant with expression of the leukocyte‐attracting chemokine CCL19, indicative of lymphoid organ functions. We did not observe recombination or gene conversion in salmon bursal lymphocytes at any developmental stage, indicating the absence of primary lymphoid organ functions in contrast to the bursa of Fabricius. However, the possibility of the bursa to trap both enteric and environmental antigens, combined with the presence of several antigen‐presenting cells residing within the lymphoepithelium, suggest the structure has secondary lymphoid organ functions. We present the discovery of a lymphoid organ in Atlantic salmon with striking topographical similarities to that of the bursa of Fabricius in birds. In addition, the age‐dependent dynamics of its lymphoepithelium suggest functions related to the maturation processes of lymphocytes. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Løken, Oskar Mongstad Bjørgen, Håvard Hordvik, Ivar Koppang, Erling Olaf |
author_facet |
Løken, Oskar Mongstad Bjørgen, Håvard Hordvik, Ivar Koppang, Erling Olaf |
author_sort |
Løken, Oskar Mongstad |
title |
A teleost structural analogue to the avian bursa of Fabricius |
title_short |
A teleost structural analogue to the avian bursa of Fabricius |
title_full |
A teleost structural analogue to the avian bursa of Fabricius |
title_fullStr |
A teleost structural analogue to the avian bursa of Fabricius |
title_full_unstemmed |
A teleost structural analogue to the avian bursa of Fabricius |
title_sort |
teleost structural analogue to the avian bursa of fabricius |
publisher |
John Wiley & Sons Ltd. |
publishDate |
2020 |
url |
http://hdl.handle.net/1956/22021 https://doi.org/10.1111/joa.13147 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Anatomy |
op_relation |
urn:issn:0021-8782 urn:issn:1469-7580 http://hdl.handle.net/1956/22021 https://doi.org/10.1111/joa.13147 cristin:1784651 |
op_rights |
Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright 2019 The Authors |
op_doi |
https://doi.org/10.1111/joa.13147 |
container_title |
Journal of Anatomy |
container_volume |
236 |
container_issue |
5 |
container_start_page |
798 |
op_container_end_page |
808 |
_version_ |
1766361547511169024 |