Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis
Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 and the associated Hippo pathway has been linked to reduced proliferation act...
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Online Access: | http://hdl.handle.net/1956/19851 https://doi.org/10.1038/s41598-018-20308-1 |
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ftunivbergen:oai:bora.uib.no:1956/19851 2023-05-15T15:30:59+02:00 Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis Kjærner-Semb, Erik Nordtorp Ayllon, Fernando Kleppe, Lene Sørhus, Elin Skaftnesmo, Kai Ove Furmanek, Tomasz Segafredo, Frida Thyri Thorsen, Anders Fjelldal, Per Gunnar Hansen, Tom Johnny Taranger, Geir Lasse Andersson, Eva Schulz, Rüdiger W. Wargelius, Anna Edvardsen, Rolf 2019-03-22T09:50:35Z application/pdf http://hdl.handle.net/1956/19851 https://doi.org/10.1038/s41598-018-20308-1 eng eng Springer Nature Norges forskningsråd: 226221 Norges forskningsråd: 221648 Norges forskningsråd: 254783 urn:issn:2045-2322 http://hdl.handle.net/1956/19851 https://doi.org/10.1038/s41598-018-20308-1 cristin:1586847 Attribution CC BY http://creativecommons.org/licenses/by/4.0 Copyright 2018 The Author(s) Scientific Reports Peer reviewed Journal article 2019 ftunivbergen https://doi.org/10.1038/s41598-018-20308-1 2023-03-14T17:42:25Z Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 and the associated Hippo pathway has been linked to reduced proliferation activity in different tissues. Analysis of gene expression reveals for the first time that vgll3 and several members of the Hippo pathway were down-regulated in salmon testis during onset of puberty and remained repressed in maturing testis. In the gonads, we found expression in Sertoli and granulosa cells in males and females, respectively. We hypothesize that vgll3 negatively regulates Sertoli cell proliferation in testis and therefore acts as an inhibitor of pubertal testis growth. Gonadal expression of vgll3 is located to somatic cells that are in direct contact with germ cells in both sexes, however our results indicate sex-biased regulation of vgll3 during puberty. publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar University of Bergen: Bergen Open Research Archive (BORA-UiB) Scientific Reports 8 1 |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
description |
Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 and the associated Hippo pathway has been linked to reduced proliferation activity in different tissues. Analysis of gene expression reveals for the first time that vgll3 and several members of the Hippo pathway were down-regulated in salmon testis during onset of puberty and remained repressed in maturing testis. In the gonads, we found expression in Sertoli and granulosa cells in males and females, respectively. We hypothesize that vgll3 negatively regulates Sertoli cell proliferation in testis and therefore acts as an inhibitor of pubertal testis growth. Gonadal expression of vgll3 is located to somatic cells that are in direct contact with germ cells in both sexes, however our results indicate sex-biased regulation of vgll3 during puberty. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Kjærner-Semb, Erik Nordtorp Ayllon, Fernando Kleppe, Lene Sørhus, Elin Skaftnesmo, Kai Ove Furmanek, Tomasz Segafredo, Frida Thyri Thorsen, Anders Fjelldal, Per Gunnar Hansen, Tom Johnny Taranger, Geir Lasse Andersson, Eva Schulz, Rüdiger W. Wargelius, Anna Edvardsen, Rolf |
spellingShingle |
Kjærner-Semb, Erik Nordtorp Ayllon, Fernando Kleppe, Lene Sørhus, Elin Skaftnesmo, Kai Ove Furmanek, Tomasz Segafredo, Frida Thyri Thorsen, Anders Fjelldal, Per Gunnar Hansen, Tom Johnny Taranger, Geir Lasse Andersson, Eva Schulz, Rüdiger W. Wargelius, Anna Edvardsen, Rolf Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis |
author_facet |
Kjærner-Semb, Erik Nordtorp Ayllon, Fernando Kleppe, Lene Sørhus, Elin Skaftnesmo, Kai Ove Furmanek, Tomasz Segafredo, Frida Thyri Thorsen, Anders Fjelldal, Per Gunnar Hansen, Tom Johnny Taranger, Geir Lasse Andersson, Eva Schulz, Rüdiger W. Wargelius, Anna Edvardsen, Rolf |
author_sort |
Kjærner-Semb, Erik Nordtorp |
title |
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis |
title_short |
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis |
title_full |
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis |
title_fullStr |
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis |
title_full_unstemmed |
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis |
title_sort |
vgll3 and the hippo pathway are regulated in sertoli cells upon entry and during puberty in atlantic salmon testis |
publisher |
Springer Nature |
publishDate |
2019 |
url |
http://hdl.handle.net/1956/19851 https://doi.org/10.1038/s41598-018-20308-1 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Scientific Reports |
op_relation |
Norges forskningsråd: 226221 Norges forskningsråd: 221648 Norges forskningsråd: 254783 urn:issn:2045-2322 http://hdl.handle.net/1956/19851 https://doi.org/10.1038/s41598-018-20308-1 cristin:1586847 |
op_rights |
Attribution CC BY http://creativecommons.org/licenses/by/4.0 Copyright 2018 The Author(s) |
op_doi |
https://doi.org/10.1038/s41598-018-20308-1 |
container_title |
Scientific Reports |
container_volume |
8 |
container_issue |
1 |
_version_ |
1766361469396451328 |