Wound healing in post-smolt Atlantic salmon (Salmo salar L.)
Skin biopsies (5 mm) taken from behind the dorsal fin on Atlantic salmon post-smolts were followed over a 2 month period. The healing process was dominated by hemostasis, acute inflammation, and epidermal repair the first 14 days post wounding (dpw), as shown through imaging, histological evaluation...
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ftunivbergen:oai:bora.uib.no:1956/19267 2023-05-15T15:30:36+02:00 Wound healing in post-smolt Atlantic salmon (Salmo salar L.) Sveen, Lene Rydal Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Handeland, Sigurd Ytteborg, Elisabeth 2019-03-05 application/pdf https://hdl.handle.net/1956/19267 https://doi.org/10.1038/s41598-019-39080-x eng eng Nature Research Aquaculture relevant stressors and their impacts on skin and wound healing in post-smolt Atlantic salmon (Salmo salar L.) urn:issn:2045-2322 https://hdl.handle.net/1956/19267 https://doi.org/10.1038/s41598-019-39080-x Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright the Author(s) 2019 3565 Scientific Reports 9 Peer reviewed Journal article 2019 ftunivbergen https://doi.org/10.1038/s41598-019-39080-x 2023-03-14T17:42:27Z Skin biopsies (5 mm) taken from behind the dorsal fin on Atlantic salmon post-smolts were followed over a 2 month period. The healing process was dominated by hemostasis, acute inflammation, and epidermal repair the first 14 days post wounding (dpw), as shown through imaging, histological evaluation, and transcriptomics. Most of the immune genes showed decreased expression after two weeks, approaching the levels of intact skin, as also reflected in sections where reduced inflammation in the wound bed was observed. Transcriptional events suggest recruitment of lymphocytes to the wound site during the acute phase, with activation of humoral responses from 14 dpw and onward. From the histology, a more adherent mucus was observed that correlated with altered transcription of glycosyltransferases. This may indicate different properties and functions of the mucus during the wound healing process. Wound contraction started between 14 and 36 dpw. The occurrence of these events was concurrent with granulation tissue formation, melanocyte migration and up-regulation of genes involved in extracellular matrix formation. The presented description of the wound healing processes in Atlantic salmon gives insight into comparative ulcerative biology in mammals and fish and provides both novel and updated knowledge that can be applied for improved best operational practices for fish welfare in aquaculture. publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar University of Bergen: Bergen Open Research Archive (BORA-UiB) Scientific Reports 9 1 |
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Open Polar |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
description |
Skin biopsies (5 mm) taken from behind the dorsal fin on Atlantic salmon post-smolts were followed over a 2 month period. The healing process was dominated by hemostasis, acute inflammation, and epidermal repair the first 14 days post wounding (dpw), as shown through imaging, histological evaluation, and transcriptomics. Most of the immune genes showed decreased expression after two weeks, approaching the levels of intact skin, as also reflected in sections where reduced inflammation in the wound bed was observed. Transcriptional events suggest recruitment of lymphocytes to the wound site during the acute phase, with activation of humoral responses from 14 dpw and onward. From the histology, a more adherent mucus was observed that correlated with altered transcription of glycosyltransferases. This may indicate different properties and functions of the mucus during the wound healing process. Wound contraction started between 14 and 36 dpw. The occurrence of these events was concurrent with granulation tissue formation, melanocyte migration and up-regulation of genes involved in extracellular matrix formation. The presented description of the wound healing processes in Atlantic salmon gives insight into comparative ulcerative biology in mammals and fish and provides both novel and updated knowledge that can be applied for improved best operational practices for fish welfare in aquaculture. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Sveen, Lene Rydal Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Handeland, Sigurd Ytteborg, Elisabeth |
spellingShingle |
Sveen, Lene Rydal Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Handeland, Sigurd Ytteborg, Elisabeth Wound healing in post-smolt Atlantic salmon (Salmo salar L.) |
author_facet |
Sveen, Lene Rydal Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Handeland, Sigurd Ytteborg, Elisabeth |
author_sort |
Sveen, Lene Rydal |
title |
Wound healing in post-smolt Atlantic salmon (Salmo salar L.) |
title_short |
Wound healing in post-smolt Atlantic salmon (Salmo salar L.) |
title_full |
Wound healing in post-smolt Atlantic salmon (Salmo salar L.) |
title_fullStr |
Wound healing in post-smolt Atlantic salmon (Salmo salar L.) |
title_full_unstemmed |
Wound healing in post-smolt Atlantic salmon (Salmo salar L.) |
title_sort |
wound healing in post-smolt atlantic salmon (salmo salar l.) |
publisher |
Nature Research |
publishDate |
2019 |
url |
https://hdl.handle.net/1956/19267 https://doi.org/10.1038/s41598-019-39080-x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
3565 Scientific Reports 9 |
op_relation |
Aquaculture relevant stressors and their impacts on skin and wound healing in post-smolt Atlantic salmon (Salmo salar L.) urn:issn:2045-2322 https://hdl.handle.net/1956/19267 https://doi.org/10.1038/s41598-019-39080-x |
op_rights |
Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright the Author(s) 2019 |
op_doi |
https://doi.org/10.1038/s41598-019-39080-x |
container_title |
Scientific Reports |
container_volume |
9 |
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1 |
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1766361047398088704 |