Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers
The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture- relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on se...
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ftunivbergen:oai:bora.uib.no:1956/19022 2023-05-15T15:31:09+02:00 Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers Sveen, Lene Rydal Grammes, Fabian Thomas Ytteborg, Elisabeth Takle, Harald Rune Jørgensen, Sven Martin 2017-10-08 application/pdf https://hdl.handle.net/1956/19022 https://doi.org/10.1371/journal.pone.0189103 eng eng PLoS Aquaculture relevant stressors and their impacts on skin and wound healing in post-smolt Atlantic salmon (Salmo salar L.) urn:issn:1932-6203 https://hdl.handle.net/1956/19022 https://doi.org/10.1371/journal.pone.0189103 cristin:1527551 Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright 2017 Sveen et al. e0189103 PLoS ONE 12 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 Peer reviewed Journal article 2017 ftunivbergen https://doi.org/10.1371/journal.pone.0189103 2023-03-14T17:38:59Z The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture- relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on several layers of evidence; annotation, transcription, phylogeny and domain structure. Two genes were annotated as muc2 and five genes as muc5. The muc2 genes were predominantly transcribed in the intestinal region while the different genes in the muc5 family were mainly transcribed in either skin, gill or pyloric caeca. In order to investigate transcriptional regulation of mucins during stress conditions, two controlled experiments were conducted. In the first experiment, handling stress induced mucin transcription in the gill, while transcription decreased in the skin and intestine. In the second experiment, long term intensive rearing conditions (fish biomass ~125 kg/m3) interrupted by additional confinement led to increased transcription of mucin genes in the skin at one, seven and fourteen days post-confinement. publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar University of Bergen: Bergen Open Research Archive (BORA-UiB) PLOS ONE 12 12 e0189103 |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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English |
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VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 |
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VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 Sveen, Lene Rydal Grammes, Fabian Thomas Ytteborg, Elisabeth Takle, Harald Rune Jørgensen, Sven Martin Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers |
topic_facet |
VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 |
description |
The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture- relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on several layers of evidence; annotation, transcription, phylogeny and domain structure. Two genes were annotated as muc2 and five genes as muc5. The muc2 genes were predominantly transcribed in the intestinal region while the different genes in the muc5 family were mainly transcribed in either skin, gill or pyloric caeca. In order to investigate transcriptional regulation of mucins during stress conditions, two controlled experiments were conducted. In the first experiment, handling stress induced mucin transcription in the gill, while transcription decreased in the skin and intestine. In the second experiment, long term intensive rearing conditions (fish biomass ~125 kg/m3) interrupted by additional confinement led to increased transcription of mucin genes in the skin at one, seven and fourteen days post-confinement. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Sveen, Lene Rydal Grammes, Fabian Thomas Ytteborg, Elisabeth Takle, Harald Rune Jørgensen, Sven Martin |
author_facet |
Sveen, Lene Rydal Grammes, Fabian Thomas Ytteborg, Elisabeth Takle, Harald Rune Jørgensen, Sven Martin |
author_sort |
Sveen, Lene Rydal |
title |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers |
title_short |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers |
title_full |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers |
title_fullStr |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers |
title_full_unstemmed |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers |
title_sort |
genome-wide analysis of atlantic salmon (salmo salar) mucin genes and their role as biomarkers |
publisher |
PLoS |
publishDate |
2017 |
url |
https://hdl.handle.net/1956/19022 https://doi.org/10.1371/journal.pone.0189103 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
e0189103 PLoS ONE 12 |
op_relation |
Aquaculture relevant stressors and their impacts on skin and wound healing in post-smolt Atlantic salmon (Salmo salar L.) urn:issn:1932-6203 https://hdl.handle.net/1956/19022 https://doi.org/10.1371/journal.pone.0189103 cristin:1527551 |
op_rights |
Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright 2017 Sveen et al. |
op_doi |
https://doi.org/10.1371/journal.pone.0189103 |
container_title |
PLOS ONE |
container_volume |
12 |
container_issue |
12 |
container_start_page |
e0189103 |
_version_ |
1766361647761326080 |