The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures
Summary: The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle factors. This highlights the impact of environmental stimuli and lifestyle during growth. Purpo...
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ftunivbergen:oai:bora.uib.no:1956/17366 2023-05-15T18:34:54+02:00 The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures Christoffersen, Tore Ahmed, Luai A. Daltveit, Anne Kjersti Dennison, Elaine Evensen, Elin Furberg, Anne-Sofie Gracia-Marco, Luis Grimnes, Guri Nilsen, Ole-Andreas Schei, Berit Tell, Grethe S. Vlachopoulous, Dimitris Winther, Anne Emaus, Nina 2018-01-30T11:09:47Z application/pdf https://hdl.handle.net/1956/17366 https://doi.org/10.1007/s11657-017-0348-x eng eng Springer urn:issn:1862-3514 https://hdl.handle.net/1956/17366 https://doi.org/10.1007/s11657-017-0348-x cristin:1478843 Archives of Osteoporosis. 2017;12:54 Copyright 2017 International Osteoporosis Foundation and National Osteoporosis Foundation 54 Archives of Osteoporosis 12 Birth weight DXA Osteoporosis Humans Bone density Peer reviewed Journal article 2018 ftunivbergen https://doi.org/10.1007/s11657-017-0348-x 2023-03-14T17:38:47Z Summary: The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle factors. This highlights the impact of environmental stimuli and lifestyle during growth. Purpose: The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents. Methods: We included 961 participants from the population-based Fit Futures study (2010–2011). Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral density (BMD) and bone mineral content (BMC) at femoral neck (FN), total hip (TH) and total body (TB). BMD and BMC measures were linked with birth weight and length ascertained from the Medical Birth Registry of Norway. Linear regression models were used to investigate the influence of birth parameters on BMD and BMC. Results: Birth weight was positively associated with BMD-TB and BMC at all sites among girls; standardized β coefficients [95% CI] were 0.11 [0.01, 0.20] for BMD-TB and 0.15 [0.06, 0.24], 0.18 [0.09, 0.28] and 0.29 [0.20, 0.38] for BMC-FN, TH and TB, respectively. In boys, birth weight was positively associated with BMC at all sites with estimates of 0.10 [0.01, 0.19], 0.12 [0.03, 0.21] and 0.15 [0.07, 0.24] for FN, TH and TB, respectively. Corresponding analyses using birth length as exposure gave significantly positive associations with BMC at all sites in both sexes. The significant positive association between birth weight and BMC-TB in girls, and birth length and BMC-TB in boys remained after multivariable adjustment. Conclusions: We found a positive association between birth size and BMC in adolescence. However, this association was attenuated after adjustment for weight, height and physical activity during adolescence. acceptedVersion Article in Journal/Newspaper Tromsø University of Bergen: Bergen Open Research Archive (BORA-UiB) Norway Tromsø Archives of Osteoporosis 12 1 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
topic |
Birth weight DXA Osteoporosis Humans Bone density |
spellingShingle |
Birth weight DXA Osteoporosis Humans Bone density Christoffersen, Tore Ahmed, Luai A. Daltveit, Anne Kjersti Dennison, Elaine Evensen, Elin Furberg, Anne-Sofie Gracia-Marco, Luis Grimnes, Guri Nilsen, Ole-Andreas Schei, Berit Tell, Grethe S. Vlachopoulous, Dimitris Winther, Anne Emaus, Nina The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures |
topic_facet |
Birth weight DXA Osteoporosis Humans Bone density |
description |
Summary: The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle factors. This highlights the impact of environmental stimuli and lifestyle during growth. Purpose: The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents. Methods: We included 961 participants from the population-based Fit Futures study (2010–2011). Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral density (BMD) and bone mineral content (BMC) at femoral neck (FN), total hip (TH) and total body (TB). BMD and BMC measures were linked with birth weight and length ascertained from the Medical Birth Registry of Norway. Linear regression models were used to investigate the influence of birth parameters on BMD and BMC. Results: Birth weight was positively associated with BMD-TB and BMC at all sites among girls; standardized β coefficients [95% CI] were 0.11 [0.01, 0.20] for BMD-TB and 0.15 [0.06, 0.24], 0.18 [0.09, 0.28] and 0.29 [0.20, 0.38] for BMC-FN, TH and TB, respectively. In boys, birth weight was positively associated with BMC at all sites with estimates of 0.10 [0.01, 0.19], 0.12 [0.03, 0.21] and 0.15 [0.07, 0.24] for FN, TH and TB, respectively. Corresponding analyses using birth length as exposure gave significantly positive associations with BMC at all sites in both sexes. The significant positive association between birth weight and BMC-TB in girls, and birth length and BMC-TB in boys remained after multivariable adjustment. Conclusions: We found a positive association between birth size and BMC in adolescence. However, this association was attenuated after adjustment for weight, height and physical activity during adolescence. acceptedVersion |
format |
Article in Journal/Newspaper |
author |
Christoffersen, Tore Ahmed, Luai A. Daltveit, Anne Kjersti Dennison, Elaine Evensen, Elin Furberg, Anne-Sofie Gracia-Marco, Luis Grimnes, Guri Nilsen, Ole-Andreas Schei, Berit Tell, Grethe S. Vlachopoulous, Dimitris Winther, Anne Emaus, Nina |
author_facet |
Christoffersen, Tore Ahmed, Luai A. Daltveit, Anne Kjersti Dennison, Elaine Evensen, Elin Furberg, Anne-Sofie Gracia-Marco, Luis Grimnes, Guri Nilsen, Ole-Andreas Schei, Berit Tell, Grethe S. Vlachopoulous, Dimitris Winther, Anne Emaus, Nina |
author_sort |
Christoffersen, Tore |
title |
The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures |
title_short |
The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures |
title_full |
The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures |
title_fullStr |
The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures |
title_full_unstemmed |
The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures |
title_sort |
influence of birth weight and length on bone mineral density and content in adolescence: the tromsø study, fit futures |
publisher |
Springer |
publishDate |
2018 |
url |
https://hdl.handle.net/1956/17366 https://doi.org/10.1007/s11657-017-0348-x |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
54 Archives of Osteoporosis 12 |
op_relation |
urn:issn:1862-3514 https://hdl.handle.net/1956/17366 https://doi.org/10.1007/s11657-017-0348-x cristin:1478843 Archives of Osteoporosis. 2017;12:54 |
op_rights |
Copyright 2017 International Osteoporosis Foundation and National Osteoporosis Foundation |
op_doi |
https://doi.org/10.1007/s11657-017-0348-x |
container_title |
Archives of Osteoporosis |
container_volume |
12 |
container_issue |
1 |
_version_ |
1766219893029470208 |