Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) c...
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Language: | English |
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Online Access: | https://hdl.handle.net/1956/17037 https://doi.org/10.1038/s41598-017-16820-5 |
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ftunivbergen:oai:bora.uib.no:1956/17037 2023-05-15T15:07:10+02:00 Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli 2017-11-28T11:46:28Z application/pdf https://hdl.handle.net/1956/17037 https://doi.org/10.1038/s41598-017-16820-5 eng eng Nature Publishing Group urn:issn:2045-2322 https://hdl.handle.net/1956/17037 https://doi.org/10.1038/s41598-017-16820-5 cristin:1519516 Attribution CC BY http://creativecommons.org/licenses/by/4.0 Copyright 2017 The Author(s) Scientific Reports Peer reviewed Journal article 2017 ftunivbergen https://doi.org/10.1038/s41598-017-16820-5 2023-03-14T17:41:57Z There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears (Ursus maritimus) from Svalbard, Norway (n = 112). We analyzed biomarkers of energy metabolism including the abundance profiles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fingerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfluoroalkyl substances were significantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the effects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs affect lipid biosynthesis and catabolism in female polar bears. Furthermore, these effects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climate-driven sea ice decline and OHCs have synergistic negative effects on polar bears. publishedVersion Article in Journal/Newspaper Arctic Sea ice Svalbard Ursus maritimus University of Bergen: Bergen Open Research Archive (BORA-UiB) Arctic Norway Svalbard Scientific Reports 7 1 |
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Open Polar |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
description |
There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears (Ursus maritimus) from Svalbard, Norway (n = 112). We analyzed biomarkers of energy metabolism including the abundance profiles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fingerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfluoroalkyl substances were significantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the effects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs affect lipid biosynthesis and catabolism in female polar bears. Furthermore, these effects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climate-driven sea ice decline and OHCs have synergistic negative effects on polar bears. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli |
spellingShingle |
Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
author_facet |
Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli |
author_sort |
Tartu, Sabrina |
title |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_short |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_full |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_fullStr |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_full_unstemmed |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_sort |
multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
publisher |
Nature Publishing Group |
publishDate |
2017 |
url |
https://hdl.handle.net/1956/17037 https://doi.org/10.1038/s41598-017-16820-5 |
geographic |
Arctic Norway Svalbard |
geographic_facet |
Arctic Norway Svalbard |
genre |
Arctic Sea ice Svalbard Ursus maritimus |
genre_facet |
Arctic Sea ice Svalbard Ursus maritimus |
op_source |
Scientific Reports |
op_relation |
urn:issn:2045-2322 https://hdl.handle.net/1956/17037 https://doi.org/10.1038/s41598-017-16820-5 cristin:1519516 |
op_rights |
Attribution CC BY http://creativecommons.org/licenses/by/4.0 Copyright 2017 The Author(s) |
op_doi |
https://doi.org/10.1038/s41598-017-16820-5 |
container_title |
Scientific Reports |
container_volume |
7 |
container_issue |
1 |
_version_ |
1766338726388039680 |