A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats
Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill...
Published in: | Marine Drugs |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI
2016
|
Subjects: | |
Online Access: | https://hdl.handle.net/1956/12496 https://doi.org/10.3390/md13074375 |
id |
ftunivbergen:oai:bora.uib.no:1956/12496 |
---|---|
record_format |
openpolar |
spelling |
ftunivbergen:oai:bora.uib.no:1956/12496 2023-05-15T13:43:11+02:00 A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats Ramsvik, Marie Sannes Bjørndal, Bodil Bruheim, Inge Bohov, Pavol Berge, Rolf Kristian 2016-04-08T11:22:15Z application/pdf https://hdl.handle.net/1956/12496 https://doi.org/10.3390/md13074375 eng eng MDPI urn:issn:1660-3397 https://hdl.handle.net/1956/12496 https://doi.org/10.3390/md13074375 cristin:1267069 Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright 2015 by the authors Antarctic krill lipogenesis plasma lipids Inflammation antioxidant capacity Omega-3 polyunsaturated fatty acids cholesterol lipid lowering VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 Peer reviewed Journal article 2016 ftunivbergen https://doi.org/10.3390/md13074375 2023-03-14T17:39:13Z Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. publishedVersion Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill University of Bergen: Bergen Open Research Archive (BORA-UiB) Antarctic Marine Drugs 13 7 4375 4397 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
topic |
Antarctic krill lipogenesis plasma lipids Inflammation antioxidant capacity Omega-3 polyunsaturated fatty acids cholesterol lipid lowering VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 |
spellingShingle |
Antarctic krill lipogenesis plasma lipids Inflammation antioxidant capacity Omega-3 polyunsaturated fatty acids cholesterol lipid lowering VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 Ramsvik, Marie Sannes Bjørndal, Bodil Bruheim, Inge Bohov, Pavol Berge, Rolf Kristian A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
topic_facet |
Antarctic krill lipogenesis plasma lipids Inflammation antioxidant capacity Omega-3 polyunsaturated fatty acids cholesterol lipid lowering VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 |
description |
Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Ramsvik, Marie Sannes Bjørndal, Bodil Bruheim, Inge Bohov, Pavol Berge, Rolf Kristian |
author_facet |
Ramsvik, Marie Sannes Bjørndal, Bodil Bruheim, Inge Bohov, Pavol Berge, Rolf Kristian |
author_sort |
Ramsvik, Marie Sannes |
title |
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
title_short |
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
title_full |
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
title_fullStr |
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
title_full_unstemmed |
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
title_sort |
phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats |
publisher |
MDPI |
publishDate |
2016 |
url |
https://hdl.handle.net/1956/12496 https://doi.org/10.3390/md13074375 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_relation |
urn:issn:1660-3397 https://hdl.handle.net/1956/12496 https://doi.org/10.3390/md13074375 cristin:1267069 |
op_rights |
Attribution CC BY http://creativecommons.org/licenses/by/4.0/ Copyright 2015 by the authors |
op_doi |
https://doi.org/10.3390/md13074375 |
container_title |
Marine Drugs |
container_volume |
13 |
container_issue |
7 |
container_start_page |
4375 |
op_container_end_page |
4397 |
_version_ |
1766185792843022336 |