Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design
Objective To assess whether use of specific selective serotonin reuptake inhibitors (SSRIs) or venlafaxine in early pregnancy is associated with an increased risk of birth defects, with emphasis on cardiovascular birth defects even when accounting for lifestyle or other familial confounding. Design...
Published in: | BMJ |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMJ Publishing Group
2016
|
Subjects: | |
Online Access: | https://hdl.handle.net/1956/12090 https://doi.org/10.1136/bmj.h1798 |
id |
ftunivbergen:oai:bora.uib.no:1956/12090 |
---|---|
record_format |
openpolar |
spelling |
ftunivbergen:oai:bora.uib.no:1956/12090 2023-05-15T16:52:45+02:00 Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design Furu, Kari Kieler, Helle Haglund, Bengt Engeland, Anders Selmer, Randi Stephansson, Olof Valdimarsdottir, Unnur Anna Zoega, Helga Artama, Miia Gissler, Mika Malm, Heli Nørgaard, Mette 2016-02-10T15:45:19Z application/pdf https://hdl.handle.net/1956/12090 https://doi.org/10.1136/bmj.h1798 eng eng BMJ Publishing Group http://www.bmj.com/content/bmj/350/bmj.h1798.full.pdf urn:issn:0959-535X https://hdl.handle.net/1956/12090 https://doi.org/10.1136/bmj.h1798 cristin:1249371 Attribution CC BY-NC http://creativecommons.org/licenses/by-nc VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700 Peer reviewed Journal article 2016 ftunivbergen https://doi.org/10.1136/bmj.h1798 2023-03-14T17:39:45Z Objective To assess whether use of specific selective serotonin reuptake inhibitors (SSRIs) or venlafaxine in early pregnancy is associated with an increased risk of birth defects, with emphasis on cardiovascular birth defects even when accounting for lifestyle or other familial confounding. Design Multicountry population based cohort study, including sibling controlled design. Setting Nordic population (Denmark, Finland, Iceland, Norway, and Sweden) identified from nationwide health registers at different periods in 1996-2010. Population The full study cohort included women giving birth to 2.3 million live singletons. The sibling cohort included 2288 singleton live births. The sibling controlled analyses included sibling pairs who were discordant for exposure to SSRIs or venlafaxine and birth defects. Main outcome measure Prevalence of birth defects, including subtypes of cardiac defects. Odds ratio of birth defects from logistic and conditional logistic regression. Results Among 36 772 infants exposed to any SSRI in early pregnancy, 3.7% (n=1357) had a birth defect compared with 3.1% of 2 266 875 unexposed infants, yielding a covariate adjusted odds ratio of 1.13 (95% confidence interval 1.06 to 1.20). In the sibling controlled analysis the adjusted odds ratio decreased to 1.06 (0.91 to 1.24). The odds ratios for any cardiac birth defect with use of any SSRI or venlafaxine were 1.15 (95% confidence interval 1.05 to 1.26) in the covariate adjusted analysis and 0.92 (0.72 to 1.17) in the sibling controlled analysis. For atrial and ventricular septal defects the covariate adjusted odds ratio was 1.17 (1.05 to 1.31). Exposure to any SSRI or venlafaxine increased the prevalence of right ventricular outflow tract obstruction defects, with a covariate adjusted odds ratio of 1.48 (1.15 to 1.89). In the sibling controlled analysis the adjusted odds ratio decreased to 0.56 (0.21 to 1.49) for any exposure to SSRIs or venlafaxine and right ventricular outflow tract obstruction defects. Conclusions In this large Nordic ... Article in Journal/Newspaper Iceland University of Bergen: Bergen Open Research Archive (BORA-UiB) Norway BMJ 350 apr17 3 h1798 h1798 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
topic |
VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700 |
spellingShingle |
VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700 Furu, Kari Kieler, Helle Haglund, Bengt Engeland, Anders Selmer, Randi Stephansson, Olof Valdimarsdottir, Unnur Anna Zoega, Helga Artama, Miia Gissler, Mika Malm, Heli Nørgaard, Mette Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design |
topic_facet |
VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700 |
description |
Objective To assess whether use of specific selective serotonin reuptake inhibitors (SSRIs) or venlafaxine in early pregnancy is associated with an increased risk of birth defects, with emphasis on cardiovascular birth defects even when accounting for lifestyle or other familial confounding. Design Multicountry population based cohort study, including sibling controlled design. Setting Nordic population (Denmark, Finland, Iceland, Norway, and Sweden) identified from nationwide health registers at different periods in 1996-2010. Population The full study cohort included women giving birth to 2.3 million live singletons. The sibling cohort included 2288 singleton live births. The sibling controlled analyses included sibling pairs who were discordant for exposure to SSRIs or venlafaxine and birth defects. Main outcome measure Prevalence of birth defects, including subtypes of cardiac defects. Odds ratio of birth defects from logistic and conditional logistic regression. Results Among 36 772 infants exposed to any SSRI in early pregnancy, 3.7% (n=1357) had a birth defect compared with 3.1% of 2 266 875 unexposed infants, yielding a covariate adjusted odds ratio of 1.13 (95% confidence interval 1.06 to 1.20). In the sibling controlled analysis the adjusted odds ratio decreased to 1.06 (0.91 to 1.24). The odds ratios for any cardiac birth defect with use of any SSRI or venlafaxine were 1.15 (95% confidence interval 1.05 to 1.26) in the covariate adjusted analysis and 0.92 (0.72 to 1.17) in the sibling controlled analysis. For atrial and ventricular septal defects the covariate adjusted odds ratio was 1.17 (1.05 to 1.31). Exposure to any SSRI or venlafaxine increased the prevalence of right ventricular outflow tract obstruction defects, with a covariate adjusted odds ratio of 1.48 (1.15 to 1.89). In the sibling controlled analysis the adjusted odds ratio decreased to 0.56 (0.21 to 1.49) for any exposure to SSRIs or venlafaxine and right ventricular outflow tract obstruction defects. Conclusions In this large Nordic ... |
format |
Article in Journal/Newspaper |
author |
Furu, Kari Kieler, Helle Haglund, Bengt Engeland, Anders Selmer, Randi Stephansson, Olof Valdimarsdottir, Unnur Anna Zoega, Helga Artama, Miia Gissler, Mika Malm, Heli Nørgaard, Mette |
author_facet |
Furu, Kari Kieler, Helle Haglund, Bengt Engeland, Anders Selmer, Randi Stephansson, Olof Valdimarsdottir, Unnur Anna Zoega, Helga Artama, Miia Gissler, Mika Malm, Heli Nørgaard, Mette |
author_sort |
Furu, Kari |
title |
Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design |
title_short |
Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design |
title_full |
Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design |
title_fullStr |
Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design |
title_full_unstemmed |
Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design |
title_sort |
selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: population based cohort study and sibling design |
publisher |
BMJ Publishing Group |
publishDate |
2016 |
url |
https://hdl.handle.net/1956/12090 https://doi.org/10.1136/bmj.h1798 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.bmj.com/content/bmj/350/bmj.h1798.full.pdf urn:issn:0959-535X https://hdl.handle.net/1956/12090 https://doi.org/10.1136/bmj.h1798 cristin:1249371 |
op_rights |
Attribution CC BY-NC http://creativecommons.org/licenses/by-nc |
op_doi |
https://doi.org/10.1136/bmj.h1798 |
container_title |
BMJ |
container_volume |
350 |
container_issue |
apr17 3 |
container_start_page |
h1798 |
op_container_end_page |
h1798 |
_version_ |
1766043130046447616 |