Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults
Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. Arctic Nutrition’s herring roe product MOPL™30 is a PL: docosahexaenoic acid (...
Published in: | Lipids in Health and Disease |
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Format: | Article in Journal/Newspaper |
Language: | English |
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BioMed Central
2015
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Online Access: | http://hdl.handle.net/1956/11208 https://doi.org/10.1186/1476-511X-13-82 |
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ftunivbergen:oai:bora.uib.no:1956/11208 2023-05-15T15:18:24+02:00 Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults Bjørndal, Bodil Strand, Elin Gjerde, Jennifer Bohov, Pavol Svardal, Asbjørn M. Diehl, Bernd W.K. Innis, Sheila M. Berger, Alvin Berge, Rolf Kristian 2015-11-26T08:47:05Z http://hdl.handle.net/1956/11208 https://doi.org/10.1186/1476-511X-13-82 eng eng BioMed Central Lipids in Health and Disease 2014, 13:82 http://hdl.handle.net/1956/11208 1164542 doi:10.1186/1476-511X-13-82 Attribution CC BY 4.0 http://creativecommons.org/licenses/by/4.0 Copyright Bjørndal et al.; licensee BioMed Central Ltd. 2014 CC-BY 1476-511X Herring roe Phospholipids Eicosapentaenoic acid Docosahexaenoic acid Omega-3 polyunsaturated fatty acids Glycemic control Choline Acylcarnitines VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 Journal article publishedVersion 2015 ftunivbergen https://doi.org/10.1186/1476-511X-13-82 2019-09-29T17:19:40Z Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. Arctic Nutrition’s herring roe product MOPL™30 is a PL: docosahexaenoic acid (DHA)-rich fish oil mixture, with a DHA:eicosapentaenoic acid (EPA) ratio of about 3:1, which is also rich in choline. In this pilot study, we determined if MOPL30 could favorably affect plasma lipid parameters and glucose tolerance in healthy young adults. Methods: Twenty female and one male adults, between 22 and 26 years of age, participated in the study. Participants took encapsulated MOPL30, 2.4 g/d EPA + DHA, for 14 days, and completed a three-day weighed food record before and during the capsule intake. Plasma lipids and their fatty acid (FA) composition, plasma and red blood cell (RBC) phosphatidylcholine (PC) FA composition, acylcarnitines, choline, betaine and insulin were measured before and after supplementation (n = 21), and one and four weeks after discontinuation of supplementation (n = 14). An oral glucose tolerance test was performed before and after supplementation. Results: Fasting plasma triacylglycerol and non-esterified fatty acids decreased and HDL-cholesterol increased after 14 days of MOPL30 intake (p < 0.05). The dietary records showed that PUFA intake prior to and during capsule intake was not different. Fasting plasma glucose was unchanged from before to after supplementation. However, during oral glucose tolerance testing, blood glucose at both 10 and 120 min was significantly lower after supplementation with MOPL30 compared to baseline measurements. Plasma free choline and betaine were increased, and the n-6/n-3 polyunsaturated (PUFA) ratio in plasma and RBC PC were decreased post-supplementation. Four weeks after discontinuation of MOPL30, most parameters had returned to baseline, but a delayed effect was observed on n-6 PUFAs. Conclusions: Herring roe rich in PL improved the plasma lipid profile and glycemic control in young adults with an overall healthy lifestyle. Article in Journal/Newspaper Arctic University of Bergen: Bergen Open Research Archive (BORA-UiB) Arctic Lipids in Health and Disease 13 1 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
topic |
Herring roe Phospholipids Eicosapentaenoic acid Docosahexaenoic acid Omega-3 polyunsaturated fatty acids Glycemic control Choline Acylcarnitines VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 |
spellingShingle |
Herring roe Phospholipids Eicosapentaenoic acid Docosahexaenoic acid Omega-3 polyunsaturated fatty acids Glycemic control Choline Acylcarnitines VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 Bjørndal, Bodil Strand, Elin Gjerde, Jennifer Bohov, Pavol Svardal, Asbjørn M. Diehl, Bernd W.K. Innis, Sheila M. Berger, Alvin Berge, Rolf Kristian Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
topic_facet |
Herring roe Phospholipids Eicosapentaenoic acid Docosahexaenoic acid Omega-3 polyunsaturated fatty acids Glycemic control Choline Acylcarnitines VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 |
description |
Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. Arctic Nutrition’s herring roe product MOPL™30 is a PL: docosahexaenoic acid (DHA)-rich fish oil mixture, with a DHA:eicosapentaenoic acid (EPA) ratio of about 3:1, which is also rich in choline. In this pilot study, we determined if MOPL30 could favorably affect plasma lipid parameters and glucose tolerance in healthy young adults. Methods: Twenty female and one male adults, between 22 and 26 years of age, participated in the study. Participants took encapsulated MOPL30, 2.4 g/d EPA + DHA, for 14 days, and completed a three-day weighed food record before and during the capsule intake. Plasma lipids and their fatty acid (FA) composition, plasma and red blood cell (RBC) phosphatidylcholine (PC) FA composition, acylcarnitines, choline, betaine and insulin were measured before and after supplementation (n = 21), and one and four weeks after discontinuation of supplementation (n = 14). An oral glucose tolerance test was performed before and after supplementation. Results: Fasting plasma triacylglycerol and non-esterified fatty acids decreased and HDL-cholesterol increased after 14 days of MOPL30 intake (p < 0.05). The dietary records showed that PUFA intake prior to and during capsule intake was not different. Fasting plasma glucose was unchanged from before to after supplementation. However, during oral glucose tolerance testing, blood glucose at both 10 and 120 min was significantly lower after supplementation with MOPL30 compared to baseline measurements. Plasma free choline and betaine were increased, and the n-6/n-3 polyunsaturated (PUFA) ratio in plasma and RBC PC were decreased post-supplementation. Four weeks after discontinuation of MOPL30, most parameters had returned to baseline, but a delayed effect was observed on n-6 PUFAs. Conclusions: Herring roe rich in PL improved the plasma lipid profile and glycemic control in young adults with an overall healthy lifestyle. |
format |
Article in Journal/Newspaper |
author |
Bjørndal, Bodil Strand, Elin Gjerde, Jennifer Bohov, Pavol Svardal, Asbjørn M. Diehl, Bernd W.K. Innis, Sheila M. Berger, Alvin Berge, Rolf Kristian |
author_facet |
Bjørndal, Bodil Strand, Elin Gjerde, Jennifer Bohov, Pavol Svardal, Asbjørn M. Diehl, Bernd W.K. Innis, Sheila M. Berger, Alvin Berge, Rolf Kristian |
author_sort |
Bjørndal, Bodil |
title |
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
title_short |
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
title_full |
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
title_fullStr |
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
title_full_unstemmed |
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
title_sort |
phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults |
publisher |
BioMed Central |
publishDate |
2015 |
url |
http://hdl.handle.net/1956/11208 https://doi.org/10.1186/1476-511X-13-82 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
1476-511X |
op_relation |
Lipids in Health and Disease 2014, 13:82 http://hdl.handle.net/1956/11208 1164542 doi:10.1186/1476-511X-13-82 |
op_rights |
Attribution CC BY 4.0 http://creativecommons.org/licenses/by/4.0 Copyright Bjørndal et al.; licensee BioMed Central Ltd. 2014 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/1476-511X-13-82 |
container_title |
Lipids in Health and Disease |
container_volume |
13 |
container_issue |
1 |
_version_ |
1766348603320696832 |