The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar)
Salmon lice (Lepeophtheirus salmonis) are a growing problem in the Norwegian aquaculture industry with an estimated annual cost of sea lice management of 525 million USD in 2019 in Norway. Numerous lice treatments exist, yet chemical methods falter as lice increasingly resist today’s commonly used p...
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The University of Bergen
2024
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ftunivbergen:oai:bora.uib.no:11250/3149474 2024-09-30T14:32:18+00:00 The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) Røiom, Astrid Therese 2024-06-03T11:02:07Z application/pdf https://hdl.handle.net/11250/3149474 eng eng The University of Bergen KJEM399 0 MAOM ORD 2024 VÅR https://hdl.handle.net/11250/3149474 Copyright the Author. All rights reserved 752299 Master thesis 2024 ftunivbergen 2024-09-03T23:49:00Z Salmon lice (Lepeophtheirus salmonis) are a growing problem in the Norwegian aquaculture industry with an estimated annual cost of sea lice management of 525 million USD in 2019 in Norway. Numerous lice treatments exist, yet chemical methods falter as lice increasingly resist today’s commonly used pharmaceuticals. Therefore, it is of interest to investigate new potential pharmaceuticals that can be used as chemical treatments in Norway. One of these potential pharmaceuticals is lufenuron, a benzoylurea, that is already used as a salmon lice treatment in some countries, such as Chile. The purpose of this thesis was to determine the levels of lufenuron in different tissue types in Atlantic salmon (Salmo salar) over time and from this data determine several pharmacokinetic parameters of lufenuron in Atlantic salmon. Understanding lufenuron’s pharmacokinetics is crucial, given its novelty as a salmon delousing agent and the current scarcity of comprehensive information. The concentration of lufenuron in the salmon tissue samples was determined using LC-MS/MS. The results showed that the concentration of lufenuron was highest in the skin and liver, while plasma had the lowest concentrations of lufenuron. The results also indicated that plasma is the main route of elimination, and the bile is the main excretory pathway for lufenuron in Atlantic salmon. In addition, the calculated half-lives of lufenuron in the different matrices suggested that lufenuron is very persistent in the tissues of Atlantic salmon compared to other veterinary drugs. Masteroppgave i kjemi KJEM399 MAMN-KJEM Master Thesis Atlantic salmon Salmo salar University of Bergen: Bergen Open Research Archive (BORA-UiB) Norway |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
topic |
752299 |
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752299 Røiom, Astrid Therese The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) |
topic_facet |
752299 |
description |
Salmon lice (Lepeophtheirus salmonis) are a growing problem in the Norwegian aquaculture industry with an estimated annual cost of sea lice management of 525 million USD in 2019 in Norway. Numerous lice treatments exist, yet chemical methods falter as lice increasingly resist today’s commonly used pharmaceuticals. Therefore, it is of interest to investigate new potential pharmaceuticals that can be used as chemical treatments in Norway. One of these potential pharmaceuticals is lufenuron, a benzoylurea, that is already used as a salmon lice treatment in some countries, such as Chile. The purpose of this thesis was to determine the levels of lufenuron in different tissue types in Atlantic salmon (Salmo salar) over time and from this data determine several pharmacokinetic parameters of lufenuron in Atlantic salmon. Understanding lufenuron’s pharmacokinetics is crucial, given its novelty as a salmon delousing agent and the current scarcity of comprehensive information. The concentration of lufenuron in the salmon tissue samples was determined using LC-MS/MS. The results showed that the concentration of lufenuron was highest in the skin and liver, while plasma had the lowest concentrations of lufenuron. The results also indicated that plasma is the main route of elimination, and the bile is the main excretory pathway for lufenuron in Atlantic salmon. In addition, the calculated half-lives of lufenuron in the different matrices suggested that lufenuron is very persistent in the tissues of Atlantic salmon compared to other veterinary drugs. Masteroppgave i kjemi KJEM399 MAMN-KJEM |
format |
Master Thesis |
author |
Røiom, Astrid Therese |
author_facet |
Røiom, Astrid Therese |
author_sort |
Røiom, Astrid Therese |
title |
The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) |
title_short |
The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) |
title_full |
The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) |
title_fullStr |
The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
The Distribution and Elimination of Lufenuron in Atlantic Salmon (Salmo salar) |
title_sort |
distribution and elimination of lufenuron in atlantic salmon (salmo salar) |
publisher |
The University of Bergen |
publishDate |
2024 |
url |
https://hdl.handle.net/11250/3149474 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
KJEM399 0 MAOM ORD 2024 VÅR https://hdl.handle.net/11250/3149474 |
op_rights |
Copyright the Author. All rights reserved |
_version_ |
1811636490716839936 |