Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua)
In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod wit...
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Online Access: | https://hdl.handle.net/11250/3126624 https://doi.org/10.1002/jat.4519 |
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ftunivbergen:oai:bora.uib.no:11250/3126624 2024-05-12T08:00:56+00:00 Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu 2023 application/pdf https://hdl.handle.net/11250/3126624 https://doi.org/10.1002/jat.4519 eng eng Wiley Norges forskningsråd: 245979 Norges forskningsråd: 184641 Norges forskningsråd: 248840 urn:issn:0260-437X https://hdl.handle.net/11250/3126624 https://doi.org/10.1002/jat.4519 cristin:2175001 Journal of Applied Toxicology. 2023, 43 (12), 1859-1871. Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright 2023 the authors Journal of Applied Toxicology 1859-1871 43 12 Journal article Peer reviewed 2023 ftunivbergen https://doi.org/10.1002/jat.4519 2024-04-17T14:00:55Z In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod with mean weight of 840 g were exposed by gavage to dietary mixtures of chlorinated (PCBs, DDT analogs, chlordane, lindane, and toxaphene), brominated (PBDEs), and fluorinated (PFOS) compounds for 4 weeks. One group received a combined mixture of all three compound groups. The results showed that the accumulated levels of chemicals in cod liver after 4 weeks of exposure reflected concentrations found in wild fish in this region. Pathway analysis revealed that the treatment effects by each of the three groups of chemicals (chlorinated, brominated, and fluorinated) converged on activation of the unfolded protein response (UPR). Upstream regulator analysis predicted that almost all the key transcription factors (XBP1, ERN1, ATF4, EIF2AK3, and NFE2L2) regulating the UPR were significantly activated. No additive effect was observed in cod co-treated with all three compound groups. In conclusion, the genome-wide transcriptomic study suggests that the UPR pathway is a sensitive common target of halogenated organic environmental pollutants in fish. publishedVersion Article in Journal/Newspaper atlantic cod Gadus morhua North Atlantic University of Bergen: Bergen Open Research Archive (BORA-UiB) Journal of Applied Toxicology 43 12 1859 1871 |
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Open Polar |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
description |
In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod with mean weight of 840 g were exposed by gavage to dietary mixtures of chlorinated (PCBs, DDT analogs, chlordane, lindane, and toxaphene), brominated (PBDEs), and fluorinated (PFOS) compounds for 4 weeks. One group received a combined mixture of all three compound groups. The results showed that the accumulated levels of chemicals in cod liver after 4 weeks of exposure reflected concentrations found in wild fish in this region. Pathway analysis revealed that the treatment effects by each of the three groups of chemicals (chlorinated, brominated, and fluorinated) converged on activation of the unfolded protein response (UPR). Upstream regulator analysis predicted that almost all the key transcription factors (XBP1, ERN1, ATF4, EIF2AK3, and NFE2L2) regulating the UPR were significantly activated. No additive effect was observed in cod co-treated with all three compound groups. In conclusion, the genome-wide transcriptomic study suggests that the UPR pathway is a sensitive common target of halogenated organic environmental pollutants in fish. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu |
spellingShingle |
Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
author_facet |
Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu |
author_sort |
Olsvik, Pål Asgeir |
title |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_short |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_full |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_fullStr |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_full_unstemmed |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_sort |
environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of atlantic cod (gadus morhua) |
publisher |
Wiley |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3126624 https://doi.org/10.1002/jat.4519 |
genre |
atlantic cod Gadus morhua North Atlantic |
genre_facet |
atlantic cod Gadus morhua North Atlantic |
op_source |
Journal of Applied Toxicology 1859-1871 43 12 |
op_relation |
Norges forskningsråd: 245979 Norges forskningsråd: 184641 Norges forskningsråd: 248840 urn:issn:0260-437X https://hdl.handle.net/11250/3126624 https://doi.org/10.1002/jat.4519 cristin:2175001 Journal of Applied Toxicology. 2023, 43 (12), 1859-1871. |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright 2023 the authors |
op_doi |
https://doi.org/10.1002/jat.4519 |
container_title |
Journal of Applied Toxicology |
container_volume |
43 |
container_issue |
12 |
container_start_page |
1859 |
op_container_end_page |
1871 |
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1798842987161059328 |