Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016
Aims To explore sex-specific time trends in atrial fibrillation (AF) incidence and to estimate the impact of changes in risk factor levels using individual participant-level data from the population-based Tromsø Study 1994–2016. Methods and results A total of 14 818 women and 13 225 men aged 25 year...
Published in: | European Journal of Preventive Cardiology |
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2023
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Online Access: | https://hdl.handle.net/11250/3043271 https://doi.org/10.1093/eurjpc/zwac234 |
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ftunivbergen:oai:bora.uib.no:11250/3043271 2023-05-15T18:34:17+02:00 Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 Sharashova, Ekaterina Gerdts, Eva Ball, Jocasta Espnes, Hilde Jacobsen, Bjarne K. Kildal, Simon Mathiesen, Ellisiv B. Njølstad, Inger Rosengren, Annika Schirmer, Henrik Wilsgaard, Tom Løchen, Maja-Lisa 2023 application/pdf https://hdl.handle.net/11250/3043271 https://doi.org/10.1093/eurjpc/zwac234 eng eng Oxford University Press urn:issn:2047-4873 https://hdl.handle.net/11250/3043271 https://doi.org/10.1093/eurjpc/zwac234 cristin:2099095 European Journal of Preventive Cardiology. 2023, 30 (1), 72–81. Navngivelse-Ikkekommersiell 4.0 Internasjonal http://creativecommons.org/licenses/by-nc/4.0/deed.no Copyright The Author(s) 2022 European Journal of Preventive Cardiology (EJPC) 72–81 30 1 Journal article Peer reviewed 2023 ftunivbergen https://doi.org/10.1093/eurjpc/zwac234 2023-03-14T17:45:02Z Aims To explore sex-specific time trends in atrial fibrillation (AF) incidence and to estimate the impact of changes in risk factor levels using individual participant-level data from the population-based Tromsø Study 1994–2016. Methods and results A total of 14 818 women and 13 225 men aged 25 years or older without AF were enrolled in the Tromsø Study between 1994 and 2008 and followed up for incident AF throughout 2016. Poisson regression was used for statistical analyses. During follow-up, age-adjusted AF incidence rates in women decreased from 1.19 to 0.71 per 1000 person-years. In men, AF incidence increased from 1.18 to 2.82 per 1000 person-years in 2004, and then declined to 1.94 per 1000 person-years in 2016. Changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP), body mass index (BMI), physical activity, smoking and alcohol consumption together accounted for 10.9% [95% confidence interval (CI): −2.4 to 28.6] of the AF incidence decline in women and for 44.7% (95% CI: 19.2; 100.0) of the AF incidence increase in men. Reduction in SBP and DBP had the largest contribution to the decrease in AF incidence in women. Increase in BMI had the largest contribution to the increase in AF incidence in men. Conclusion In the population-based Tromsø Study 1994–2016, AF incidence decreased in women and increased following a reverse U-shape in men. Individual changes in SBP and DBP in women and individual changes in BMI in men were the most important risk factors contributing to the AF incidence trends. publishedVersion Article in Journal/Newspaper Tromsø University of Bergen: Bergen Open Research Archive (BORA-UiB) Tromsø European Journal of Preventive Cardiology 30 1 72 81 |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
description |
Aims To explore sex-specific time trends in atrial fibrillation (AF) incidence and to estimate the impact of changes in risk factor levels using individual participant-level data from the population-based Tromsø Study 1994–2016. Methods and results A total of 14 818 women and 13 225 men aged 25 years or older without AF were enrolled in the Tromsø Study between 1994 and 2008 and followed up for incident AF throughout 2016. Poisson regression was used for statistical analyses. During follow-up, age-adjusted AF incidence rates in women decreased from 1.19 to 0.71 per 1000 person-years. In men, AF incidence increased from 1.18 to 2.82 per 1000 person-years in 2004, and then declined to 1.94 per 1000 person-years in 2016. Changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP), body mass index (BMI), physical activity, smoking and alcohol consumption together accounted for 10.9% [95% confidence interval (CI): −2.4 to 28.6] of the AF incidence decline in women and for 44.7% (95% CI: 19.2; 100.0) of the AF incidence increase in men. Reduction in SBP and DBP had the largest contribution to the decrease in AF incidence in women. Increase in BMI had the largest contribution to the increase in AF incidence in men. Conclusion In the population-based Tromsø Study 1994–2016, AF incidence decreased in women and increased following a reverse U-shape in men. Individual changes in SBP and DBP in women and individual changes in BMI in men were the most important risk factors contributing to the AF incidence trends. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Sharashova, Ekaterina Gerdts, Eva Ball, Jocasta Espnes, Hilde Jacobsen, Bjarne K. Kildal, Simon Mathiesen, Ellisiv B. Njølstad, Inger Rosengren, Annika Schirmer, Henrik Wilsgaard, Tom Løchen, Maja-Lisa |
spellingShingle |
Sharashova, Ekaterina Gerdts, Eva Ball, Jocasta Espnes, Hilde Jacobsen, Bjarne K. Kildal, Simon Mathiesen, Ellisiv B. Njølstad, Inger Rosengren, Annika Schirmer, Henrik Wilsgaard, Tom Løchen, Maja-Lisa Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 |
author_facet |
Sharashova, Ekaterina Gerdts, Eva Ball, Jocasta Espnes, Hilde Jacobsen, Bjarne K. Kildal, Simon Mathiesen, Ellisiv B. Njølstad, Inger Rosengren, Annika Schirmer, Henrik Wilsgaard, Tom Løchen, Maja-Lisa |
author_sort |
Sharashova, Ekaterina |
title |
Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 |
title_short |
Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 |
title_full |
Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 |
title_fullStr |
Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 |
title_full_unstemmed |
Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 |
title_sort |
sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the tromsø study 1994–2016 |
publisher |
Oxford University Press |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3043271 https://doi.org/10.1093/eurjpc/zwac234 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
European Journal of Preventive Cardiology (EJPC) 72–81 30 1 |
op_relation |
urn:issn:2047-4873 https://hdl.handle.net/11250/3043271 https://doi.org/10.1093/eurjpc/zwac234 cristin:2099095 European Journal of Preventive Cardiology. 2023, 30 (1), 72–81. |
op_rights |
Navngivelse-Ikkekommersiell 4.0 Internasjonal http://creativecommons.org/licenses/by-nc/4.0/deed.no Copyright The Author(s) 2022 |
op_doi |
https://doi.org/10.1093/eurjpc/zwac234 |
container_title |
European Journal of Preventive Cardiology |
container_volume |
30 |
container_issue |
1 |
container_start_page |
72 |
op_container_end_page |
81 |
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1766218975422709760 |