Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries
Objective: To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs. Design: Population based cohort study using data from the national heal...
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ftunivbergen:oai:bora.uib.no:11250/2994942 2023-05-15T16:51:41+02:00 Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries Kieler, Helle Artama, Miia Engeland, Anders Ericsson, Örjan Furu, Kari Gissler, Mika Nielsen, Rikke Beck Nørgaard, Mette Stephansson, Olof Valdimarsdottir, Unnur Zoega, Helga Haglund, Bengt 2012-01-12 application/pdf https://hdl.handle.net/11250/2994942 https://doi.org/10.1136/bmj.d8012 eng eng BMJ http://www.bmj.com/highwire/filestream/557867/field_highwire_article_pdf/0.pdf urn:issn:0959-8146 https://hdl.handle.net/11250/2994942 https://doi.org/10.1136/bmj.d8012 cristin:922791 BMJ. British Medical Journal. 2012, 344, d8012. Navngivelse-Ikkekommersiell 4.0 Internasjonal http://creativecommons.org/licenses/by-nc/4.0/deed.no d8012 BMJ. British Medical Journal 344 Lungesykdommer Lung Diseases Mor-barn helse Mother-child health Spedbarn Infant Kardiovaskulær medisin Cardiovascular medicine VDP::Gynekologi og obstetrikk: 756 VDP::Gynaecology and obstetrics: 756 Journal article 2012 ftunivbergen https://doi.org/10.1136/bmj.d8012 2023-03-14T17:40:32Z Objective: To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs. Design: Population based cohort study using data from the national health registers. Setting: Denmark, Finland, Iceland, Norway, and Sweden, 1996-2007. Participants: More than 1.6 million infants born after gestational week 33. Main outcome measures: Risks of persistent pulmonary hypertension of the newborn associated with early and late exposure to SSRIs during pregnancy and adjusted for important maternal and pregnancy characteristics. Comparisons were made between infants exposed and not exposed to SSRIs. Results: Around 30 000 women had used SSRIs during pregnancy and 11 014 had been dispensed an SSRI later than gestational week 20. Exposure to SSRIs in late pregnancy was associated with an increased risk of persistent pulmonary hypertension in the newborn: 33 of 11 014 exposed infants (absolute risk 3 per 1000 liveborn infants compared with the background incidence of 1.2 per 1000); adjusted odds ratio 2.1 (95% confidence interval 1.5 to 3.0). The increased risks of persistent pulmonary hypertension in the newborn for each of the specific SSRIs (sertraline, citalopram, paroxetine, and fluoxetine) were of similar magnitude. Filling a prescription with SSRIs before gestational week 8 yielded slightly increased risks: adjusted odds ratio 1.4 (95% confidence interval 1.0 to 2.0). Conclusions: The risk of persistent pulmonary hypertension of the newborn is low, but use of SSRIs in late pregnancy increases that risk more than twofold. The increased risk seems to be a class effect. publishedVersion Article in Journal/Newspaper Iceland University of Bergen: Bergen Open Research Archive (BORA-UiB) Norway BMJ 344 jan12 3 d8012 d8012 |
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Open Polar |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
topic |
Lungesykdommer Lung Diseases Mor-barn helse Mother-child health Spedbarn Infant Kardiovaskulær medisin Cardiovascular medicine VDP::Gynekologi og obstetrikk: 756 VDP::Gynaecology and obstetrics: 756 |
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Lungesykdommer Lung Diseases Mor-barn helse Mother-child health Spedbarn Infant Kardiovaskulær medisin Cardiovascular medicine VDP::Gynekologi og obstetrikk: 756 VDP::Gynaecology and obstetrics: 756 Kieler, Helle Artama, Miia Engeland, Anders Ericsson, Örjan Furu, Kari Gissler, Mika Nielsen, Rikke Beck Nørgaard, Mette Stephansson, Olof Valdimarsdottir, Unnur Zoega, Helga Haglund, Bengt Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries |
topic_facet |
Lungesykdommer Lung Diseases Mor-barn helse Mother-child health Spedbarn Infant Kardiovaskulær medisin Cardiovascular medicine VDP::Gynekologi og obstetrikk: 756 VDP::Gynaecology and obstetrics: 756 |
description |
Objective: To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs. Design: Population based cohort study using data from the national health registers. Setting: Denmark, Finland, Iceland, Norway, and Sweden, 1996-2007. Participants: More than 1.6 million infants born after gestational week 33. Main outcome measures: Risks of persistent pulmonary hypertension of the newborn associated with early and late exposure to SSRIs during pregnancy and adjusted for important maternal and pregnancy characteristics. Comparisons were made between infants exposed and not exposed to SSRIs. Results: Around 30 000 women had used SSRIs during pregnancy and 11 014 had been dispensed an SSRI later than gestational week 20. Exposure to SSRIs in late pregnancy was associated with an increased risk of persistent pulmonary hypertension in the newborn: 33 of 11 014 exposed infants (absolute risk 3 per 1000 liveborn infants compared with the background incidence of 1.2 per 1000); adjusted odds ratio 2.1 (95% confidence interval 1.5 to 3.0). The increased risks of persistent pulmonary hypertension in the newborn for each of the specific SSRIs (sertraline, citalopram, paroxetine, and fluoxetine) were of similar magnitude. Filling a prescription with SSRIs before gestational week 8 yielded slightly increased risks: adjusted odds ratio 1.4 (95% confidence interval 1.0 to 2.0). Conclusions: The risk of persistent pulmonary hypertension of the newborn is low, but use of SSRIs in late pregnancy increases that risk more than twofold. The increased risk seems to be a class effect. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Kieler, Helle Artama, Miia Engeland, Anders Ericsson, Örjan Furu, Kari Gissler, Mika Nielsen, Rikke Beck Nørgaard, Mette Stephansson, Olof Valdimarsdottir, Unnur Zoega, Helga Haglund, Bengt |
author_facet |
Kieler, Helle Artama, Miia Engeland, Anders Ericsson, Örjan Furu, Kari Gissler, Mika Nielsen, Rikke Beck Nørgaard, Mette Stephansson, Olof Valdimarsdottir, Unnur Zoega, Helga Haglund, Bengt |
author_sort |
Kieler, Helle |
title |
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries |
title_short |
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries |
title_full |
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries |
title_fullStr |
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries |
title_full_unstemmed |
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries |
title_sort |
selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five nordic countries |
publisher |
BMJ |
publishDate |
2012 |
url |
https://hdl.handle.net/11250/2994942 https://doi.org/10.1136/bmj.d8012 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
d8012 BMJ. British Medical Journal 344 |
op_relation |
http://www.bmj.com/highwire/filestream/557867/field_highwire_article_pdf/0.pdf urn:issn:0959-8146 https://hdl.handle.net/11250/2994942 https://doi.org/10.1136/bmj.d8012 cristin:922791 BMJ. British Medical Journal. 2012, 344, d8012. |
op_rights |
Navngivelse-Ikkekommersiell 4.0 Internasjonal http://creativecommons.org/licenses/by-nc/4.0/deed.no |
op_doi |
https://doi.org/10.1136/bmj.d8012 |
container_title |
BMJ |
container_volume |
344 |
container_issue |
jan12 3 |
container_start_page |
d8012 |
op_container_end_page |
d8012 |
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1766041794010677248 |