Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco
Plasma total homocysteine (tHcy) is a risk marker, and smoking is an established risk factor for cardiovascular disease. It is unclear if the effect of smoked tobacco on homocysteine is mediated by nicotine or other combustion products in smoked tobacco. Snus (moist smokeless tobacco) is high nicoti...
Published in: | International Journal of Environmental Research and Public Health |
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Online Access: | https://hdl.handle.net/11250/2991655 https://doi.org/10.3390/ijerph182111365 |
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ftunivbergen:oai:bora.uib.no:11250/2991655 2023-05-15T17:44:44+02:00 Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco Söderström, Elisabet Nilsson, Torbjörn K. Schneede, Jörn Ueland, Per-Magne Midttun, Øivind Gylling, Björn Johansson, Ingegerd Hultdin, Johan 2021 application/pdf https://hdl.handle.net/11250/2991655 https://doi.org/10.3390/ijerph182111365 eng eng MDPI urn:issn:1661-7827 https://hdl.handle.net/11250/2991655 https://doi.org/10.3390/ijerph182111365 cristin:1964305 International Journal of Environmental Research and Public Health (IJERPH). 2021, 18 (21), 11365. Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright 2021 The Author(s) 11365 International Journal of Environmental Research and Public Health (IJERPH) 18 21 Journal article Peer reviewed 2021 ftunivbergen https://doi.org/10.3390/ijerph182111365 2023-03-14T17:43:58Z Plasma total homocysteine (tHcy) is a risk marker, and smoking is an established risk factor for cardiovascular disease. It is unclear if the effect of smoked tobacco on homocysteine is mediated by nicotine or other combustion products in smoked tobacco. Snus (moist smokeless tobacco) is high nicotine-containing tobacco, and little is known about the effect of snus on plasma homocysteine. Therefore, we studied, in a cross-section of subjects (n = 1375) from the Northern Sweden Health and Disease Study, with strictly defined current smokers (n = 194) and snus users (n = 47), the impact of tobacco exposure on tHcy, assessed by self-reported tobacco habits and plasma cotinine concentrations. The snus users had higher cotinine concentrations than the smokers. Cotinine, creatinine, methylmalonic acid, and the methylenetetrahydrofolate reductase genotype (MTHFR) T allele were positively associated with tHcy among the smokers, but not among the snus users. No association was observed between tHcy and the number of cigarettes/day. There was a positive association between cotinine and tHcy in the smokers, but not among the snus users. This indicates that substances other than nicotine in tobacco smoke could be responsible for the differential effects on homocysteine status. Self-reported smoking should be complemented by a cotinine assay whenever possible. publishedVersion Article in Journal/Newspaper Northern Sweden University of Bergen: Bergen Open Research Archive (BORA-UiB) International Journal of Environmental Research and Public Health 18 21 11365 |
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Open Polar |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
description |
Plasma total homocysteine (tHcy) is a risk marker, and smoking is an established risk factor for cardiovascular disease. It is unclear if the effect of smoked tobacco on homocysteine is mediated by nicotine or other combustion products in smoked tobacco. Snus (moist smokeless tobacco) is high nicotine-containing tobacco, and little is known about the effect of snus on plasma homocysteine. Therefore, we studied, in a cross-section of subjects (n = 1375) from the Northern Sweden Health and Disease Study, with strictly defined current smokers (n = 194) and snus users (n = 47), the impact of tobacco exposure on tHcy, assessed by self-reported tobacco habits and plasma cotinine concentrations. The snus users had higher cotinine concentrations than the smokers. Cotinine, creatinine, methylmalonic acid, and the methylenetetrahydrofolate reductase genotype (MTHFR) T allele were positively associated with tHcy among the smokers, but not among the snus users. No association was observed between tHcy and the number of cigarettes/day. There was a positive association between cotinine and tHcy in the smokers, but not among the snus users. This indicates that substances other than nicotine in tobacco smoke could be responsible for the differential effects on homocysteine status. Self-reported smoking should be complemented by a cotinine assay whenever possible. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Söderström, Elisabet Nilsson, Torbjörn K. Schneede, Jörn Ueland, Per-Magne Midttun, Øivind Gylling, Björn Johansson, Ingegerd Hultdin, Johan |
spellingShingle |
Söderström, Elisabet Nilsson, Torbjörn K. Schneede, Jörn Ueland, Per-Magne Midttun, Øivind Gylling, Björn Johansson, Ingegerd Hultdin, Johan Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
author_facet |
Söderström, Elisabet Nilsson, Torbjörn K. Schneede, Jörn Ueland, Per-Magne Midttun, Øivind Gylling, Björn Johansson, Ingegerd Hultdin, Johan |
author_sort |
Söderström, Elisabet |
title |
Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
title_short |
Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
title_full |
Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
title_fullStr |
Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
title_full_unstemmed |
Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
title_sort |
plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco |
publisher |
MDPI |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2991655 https://doi.org/10.3390/ijerph182111365 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
11365 International Journal of Environmental Research and Public Health (IJERPH) 18 21 |
op_relation |
urn:issn:1661-7827 https://hdl.handle.net/11250/2991655 https://doi.org/10.3390/ijerph182111365 cristin:1964305 International Journal of Environmental Research and Public Health (IJERPH). 2021, 18 (21), 11365. |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright 2021 The Author(s) |
op_doi |
https://doi.org/10.3390/ijerph182111365 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
18 |
container_issue |
21 |
container_start_page |
11365 |
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1766147019593744384 |