The chemical defensome of five model teleost fish
How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants,...
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ftunivbergen:oai:bora.uib.no:11250/2977982 2023-05-15T15:27:19+02:00 The chemical defensome of five model teleost fish Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders 2021 application/pdf https://hdl.handle.net/11250/2977982 https://doi.org/10.1038/s41598-021-89948-0 eng eng Nature Research Norges forskningsråd: 248840 National Institutes of Health: R01ES029917 Norges forskningsråd: 192441 Norges forskningsråd: 244654 National Institutes of Health: P42ES007381 National Institutes of Health: R21HD073805 urn:issn:2045-2322 https://hdl.handle.net/11250/2977982 https://doi.org/10.1038/s41598-021-89948-0 cristin:1912257 Scientific Reports. 2021, 11, 10546. Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright The Author(s) 2021 10546 Scientific Reports 11 Journal article Peer reviewed 2021 ftunivbergen https://doi.org/10.1038/s41598-021-89948-0 2023-03-14T17:38:49Z How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies. publishedVersion Article in Journal/Newspaper atlantic cod Gadus morhua University of Bergen: Bergen Open Research Archive (BORA-UiB) Scientific Reports 11 1 |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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English |
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How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders |
spellingShingle |
Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders The chemical defensome of five model teleost fish |
author_facet |
Eide, Marta Zhang, Xiaokang Karlsen, Odd André Goldstone, Jared V. Stegeman, John Jonassen, Inge Goksøyr, Anders |
author_sort |
Eide, Marta |
title |
The chemical defensome of five model teleost fish |
title_short |
The chemical defensome of five model teleost fish |
title_full |
The chemical defensome of five model teleost fish |
title_fullStr |
The chemical defensome of five model teleost fish |
title_full_unstemmed |
The chemical defensome of five model teleost fish |
title_sort |
chemical defensome of five model teleost fish |
publisher |
Nature Research |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2977982 https://doi.org/10.1038/s41598-021-89948-0 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
10546 Scientific Reports 11 |
op_relation |
Norges forskningsråd: 248840 National Institutes of Health: R01ES029917 Norges forskningsråd: 192441 Norges forskningsråd: 244654 National Institutes of Health: P42ES007381 National Institutes of Health: R21HD073805 urn:issn:2045-2322 https://hdl.handle.net/11250/2977982 https://doi.org/10.1038/s41598-021-89948-0 cristin:1912257 Scientific Reports. 2021, 11, 10546. |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright The Author(s) 2021 |
op_doi |
https://doi.org/10.1038/s41598-021-89948-0 |
container_title |
Scientific Reports |
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11 |
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1 |
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1766357765993791488 |