Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial
Purpose Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxid...
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ftunivbergen:oai:bora.uib.no:11250/2767319 2023-05-15T15:27:41+02:00 Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun Anita 2021 application/pdf https://hdl.handle.net/11250/2767319 https://doi.org/10.1007/s00394-021-02497-0 eng eng Springer urn:issn:1436-6207 https://hdl.handle.net/11250/2767319 https://doi.org/10.1007/s00394-021-02497-0 cristin:1914462 European Journal of Nutrition. 2021, 60, 3237-3248. Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright The Author(s) 2021 European Journal of Nutrition 3237-3248 60 Journal article Peer reviewed 2021 ftunivbergen https://doi.org/10.1007/s00394-021-02497-0 2023-03-14T17:43:58Z Purpose Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxidant vitamins and elements essential for activity of antioxidant enzymes. Methods In this randomised clinical trial, 63 participants with overweight/obesity consumed 750 g/week of either Atlantic cod (N = 22) or Atlantic salmon (N = 22) or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks. Food intake was recorded, and fasting serum were collected at baseline and endpoint. Results Serum total neopterin concentration was reduced in the Cod group (median change − 2.65 (25th, 75th percentiles − 3.68, − 0.45) nmol/l, P = 0.018) but not in the Salmon group (median change 0.00 (25th, 75th percentiles − 4.15, 3.05) nmol/l, P = 0.59) when compared with the Control group after 8 weeks. The estimated daily intake of selenium, iron, magnesium and zinc were similar between all groups. Increased serum concentration of selenium was observed only after cod intake when compared to the Control group (P = 0.017). Changes in serum concentrations of copper, iron, magnesium, all-trans retinol, α-tocopherol and γ-tocopherol were similar between the groups. Conclusion A high intake of cod, but not of salmon, lowered serum total neopterin concentration when compared to the Control group. publishedVersion Article in Journal/Newspaper atlantic cod Atlantic salmon University of Bergen: Bergen Open Research Archive (BORA-UiB) European Journal of Nutrition 60 6 3237 3248 |
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Open Polar |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
language |
English |
description |
Purpose Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxidant vitamins and elements essential for activity of antioxidant enzymes. Methods In this randomised clinical trial, 63 participants with overweight/obesity consumed 750 g/week of either Atlantic cod (N = 22) or Atlantic salmon (N = 22) or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks. Food intake was recorded, and fasting serum were collected at baseline and endpoint. Results Serum total neopterin concentration was reduced in the Cod group (median change − 2.65 (25th, 75th percentiles − 3.68, − 0.45) nmol/l, P = 0.018) but not in the Salmon group (median change 0.00 (25th, 75th percentiles − 4.15, 3.05) nmol/l, P = 0.59) when compared with the Control group after 8 weeks. The estimated daily intake of selenium, iron, magnesium and zinc were similar between all groups. Increased serum concentration of selenium was observed only after cod intake when compared to the Control group (P = 0.017). Changes in serum concentrations of copper, iron, magnesium, all-trans retinol, α-tocopherol and γ-tocopherol were similar between the groups. Conclusion A high intake of cod, but not of salmon, lowered serum total neopterin concentration when compared to the Control group. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun Anita |
spellingShingle |
Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun Anita Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
author_facet |
Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun Anita |
author_sort |
Helland, Anita |
title |
Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_short |
Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_full |
Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_fullStr |
Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_full_unstemmed |
Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_sort |
efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
publisher |
Springer |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2767319 https://doi.org/10.1007/s00394-021-02497-0 |
genre |
atlantic cod Atlantic salmon |
genre_facet |
atlantic cod Atlantic salmon |
op_source |
European Journal of Nutrition 3237-3248 60 |
op_relation |
urn:issn:1436-6207 https://hdl.handle.net/11250/2767319 https://doi.org/10.1007/s00394-021-02497-0 cristin:1914462 European Journal of Nutrition. 2021, 60, 3237-3248. |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Copyright The Author(s) 2021 |
op_doi |
https://doi.org/10.1007/s00394-021-02497-0 |
container_title |
European Journal of Nutrition |
container_volume |
60 |
container_issue |
6 |
container_start_page |
3237 |
op_container_end_page |
3248 |
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1766358095354658816 |