Antipsychotic drug use in pregnancy: A multinational study from ten countries
Aim To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Austral...
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Online Access: | https://hdl.handle.net/11250/2739380 https://doi.org/10.1016/j.schres.2020.03.048 |
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ftunivbergen:oai:bora.uib.no:11250/2739380 2023-05-15T16:51:25+02:00 Antipsychotic drug use in pregnancy: A multinational study from ten countries Reutfors, Johan Cesta, Carolyn Cohen, Jacqueline Mallory Bateman, Brian T Brauer, Ruth Einarsdottir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit Li, Jiong Man, Kenneth K. C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella 2020 application/pdf https://hdl.handle.net/11250/2739380 https://doi.org/10.1016/j.schres.2020.03.048 eng eng Elsevier https://www.sciencedirect.com/science/article/pii/S0920996420301584 urn:issn:0920-9964 https://hdl.handle.net/11250/2739380 https://doi.org/10.1016/j.schres.2020.03.048 cristin:1832124 Schizophrenia Research. 2020, 220: 106-115 Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no Copyright 2020 The Authors Schizophrenia Research 220 June 106-115 Journal article Peer reviewed 2020 ftunivbergen https://doi.org/10.1016/j.schres.2020.03.048 2023-03-14T17:41:34Z Aim To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Australia (New South Wales, 2004–2012), Hong Kong (2001–2015), UK (2006–2016), and the US (Medicaid, 2000–2013, and IBM MarketScan, 2012–2015) were used. Using a uniformed approach, we estimated the prevalence of antipsychotic use as the proportion of pregnancies where a woman filled at least one antipsychotic prescription within three months before pregnancy until birth. For the Nordic countries, data were meta-analyzed to investigate maternal characteristics associated with the use of antipsychotics. Results We included 8,394,343 pregnancies. Typical antipsychotic use was highest in the UK (4.4%) whereas atypical antipsychotic use was highest in the US Medicaid (1.5%). Atypical antipsychotic use increased over time in most populations, reaching 2% in Australia (2012) and US Medicaid (2013). In most countries, prochlorperazine was the most commonly used typical antipsychotic and quetiapine the most commonly used atypical antipsychotic. Use of antipsychotics decreased across the trimesters of pregnancy in all populations except Finland. Antipsychotic use was elevated among smokers and those with parity ≥4 in the Nordic countries. Conclusion Antipsychotic use during pregnancy varied considerably between populations, partly explained by varying use of the typical antipsychotic prochlorperazine, which is often used for nausea and vomiting in early pregnancy. Increasing usage of atypical antipsychotics among pregnant women reflects the pattern that was previously reported for the general population. publishedVersion Article in Journal/Newspaper Iceland University of Bergen: Bergen Open Research Archive (BORA-UiB) Norway Schizophrenia Research 220 106 115 |
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University of Bergen: Bergen Open Research Archive (BORA-UiB) |
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ftunivbergen |
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English |
description |
Aim To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Australia (New South Wales, 2004–2012), Hong Kong (2001–2015), UK (2006–2016), and the US (Medicaid, 2000–2013, and IBM MarketScan, 2012–2015) were used. Using a uniformed approach, we estimated the prevalence of antipsychotic use as the proportion of pregnancies where a woman filled at least one antipsychotic prescription within three months before pregnancy until birth. For the Nordic countries, data were meta-analyzed to investigate maternal characteristics associated with the use of antipsychotics. Results We included 8,394,343 pregnancies. Typical antipsychotic use was highest in the UK (4.4%) whereas atypical antipsychotic use was highest in the US Medicaid (1.5%). Atypical antipsychotic use increased over time in most populations, reaching 2% in Australia (2012) and US Medicaid (2013). In most countries, prochlorperazine was the most commonly used typical antipsychotic and quetiapine the most commonly used atypical antipsychotic. Use of antipsychotics decreased across the trimesters of pregnancy in all populations except Finland. Antipsychotic use was elevated among smokers and those with parity ≥4 in the Nordic countries. Conclusion Antipsychotic use during pregnancy varied considerably between populations, partly explained by varying use of the typical antipsychotic prochlorperazine, which is often used for nausea and vomiting in early pregnancy. Increasing usage of atypical antipsychotics among pregnant women reflects the pattern that was previously reported for the general population. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Reutfors, Johan Cesta, Carolyn Cohen, Jacqueline Mallory Bateman, Brian T Brauer, Ruth Einarsdottir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit Li, Jiong Man, Kenneth K. C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella |
spellingShingle |
Reutfors, Johan Cesta, Carolyn Cohen, Jacqueline Mallory Bateman, Brian T Brauer, Ruth Einarsdottir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit Li, Jiong Man, Kenneth K. C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella Antipsychotic drug use in pregnancy: A multinational study from ten countries |
author_facet |
Reutfors, Johan Cesta, Carolyn Cohen, Jacqueline Mallory Bateman, Brian T Brauer, Ruth Einarsdottir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit Li, Jiong Man, Kenneth K. C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella |
author_sort |
Reutfors, Johan |
title |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_short |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_full |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_fullStr |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_full_unstemmed |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_sort |
antipsychotic drug use in pregnancy: a multinational study from ten countries |
publisher |
Elsevier |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2739380 https://doi.org/10.1016/j.schres.2020.03.048 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Schizophrenia Research 220 June 106-115 |
op_relation |
https://www.sciencedirect.com/science/article/pii/S0920996420301584 urn:issn:0920-9964 https://hdl.handle.net/11250/2739380 https://doi.org/10.1016/j.schres.2020.03.048 cristin:1832124 Schizophrenia Research. 2020, 220: 106-115 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no Copyright 2020 The Authors |
op_doi |
https://doi.org/10.1016/j.schres.2020.03.048 |
container_title |
Schizophrenia Research |
container_volume |
220 |
container_start_page |
106 |
op_container_end_page |
115 |
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1766041524865335296 |