Environmental pollutants in blood donors: The multicentre Norwegian donor study
Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and pr...
Published in: | Transfusion Medicine |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/11250/2730414 https://doi.org/10.1111/tme.12662 |
id |
ftunivbergen:oai:bora.uib.no:11250/2730414 |
---|---|
record_format |
openpolar |
spelling |
ftunivbergen:oai:bora.uib.no:11250/2730414 2023-05-15T17:03:59+02:00 Environmental pollutants in blood donors: The multicentre Norwegian donor study Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan 2020 application/pdf https://hdl.handle.net/11250/2730414 https://doi.org/10.1111/tme.12662 eng eng Wiley urn:issn:0958-7578 https://hdl.handle.net/11250/2730414 https://doi.org/10.1111/tme.12662 cristin:1796445 Transfusion Medicine. 2020, 30 (3), 201-209. Navngivelse-Ikkekommersiell 4.0 Internasjonal http://creativecommons.org/licenses/by-nc/4.0/deed.no Copyright 2020 The Authors. Transfusion Medicine 201-209 30 3 Journal article Peer reviewed 2020 ftunivbergen https://doi.org/10.1111/tme.12662 2023-03-14T17:40:00Z Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants. publishedVersion Article in Journal/Newspaper Kirkenes Tromsø University of Bergen: Bergen Open Research Archive (BORA-UiB) Bergen Tromsø Transfusion Medicine 30 3 201 209 |
institution |
Open Polar |
collection |
University of Bergen: Bergen Open Research Archive (BORA-UiB) |
op_collection_id |
ftunivbergen |
language |
English |
description |
Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan |
spellingShingle |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan Environmental pollutants in blood donors: The multicentre Norwegian donor study |
author_facet |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar Klæboe Bolann, Bjørn Johan |
author_sort |
Averina, Maria |
title |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_short |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_full |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_fullStr |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_full_unstemmed |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_sort |
environmental pollutants in blood donors: the multicentre norwegian donor study |
publisher |
Wiley |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2730414 https://doi.org/10.1111/tme.12662 |
geographic |
Bergen Tromsø |
geographic_facet |
Bergen Tromsø |
genre |
Kirkenes Tromsø |
genre_facet |
Kirkenes Tromsø |
op_source |
Transfusion Medicine 201-209 30 3 |
op_relation |
urn:issn:0958-7578 https://hdl.handle.net/11250/2730414 https://doi.org/10.1111/tme.12662 cristin:1796445 Transfusion Medicine. 2020, 30 (3), 201-209. |
op_rights |
Navngivelse-Ikkekommersiell 4.0 Internasjonal http://creativecommons.org/licenses/by-nc/4.0/deed.no Copyright 2020 The Authors. |
op_doi |
https://doi.org/10.1111/tme.12662 |
container_title |
Transfusion Medicine |
container_volume |
30 |
container_issue |
3 |
container_start_page |
201 |
op_container_end_page |
209 |
_version_ |
1766057989694816256 |