A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus)
Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the areas covered by their mosquito vectors, may...
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2023
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Online Access: | https://hdl.handle.net/11586/453782 https://doi.org/10.3390/ani13223457 https://www.mdpi.com/2076-2615/13/22/3457 |
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ftunivbari:oai:ricerca.uniba.it:11586/453782 2024-04-21T07:59:00+00:00 A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) Nicola Pugliese Rossella Samarelli Roberto Lombardi Antonella Schiavone Giuseppe Crescenzo Elena Circella Claudia Zizzadoro Olimpia Lai Medhat S. Saleh Michela Prioletti Antonio Camarda Pugliese, Nicola Samarelli, Rossella Lombardi, Roberto Schiavone, Antonella Crescenzo, Giuseppe Circella, Elena Zizzadoro, Claudia Lai, Olimpia Saleh, Medhat S. Prioletti, Michela Camarda, Antonio 2023 https://hdl.handle.net/11586/453782 https://doi.org/10.3390/ani13223457 https://www.mdpi.com/2076-2615/13/22/3457 eng eng info:eu-repo/semantics/altIdentifier/pmid/38003076 info:eu-repo/semantics/altIdentifier/wos/WOS:001109552000001 volume:13 issue:22 firstpage:3457 numberofpages:10 journal:ANIMALS https://hdl.handle.net/11586/453782 doi:10.3390/ani13223457 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85178371846 https://www.mdpi.com/2076-2615/13/22/3457 Bubo scandiacus Plasmodium relictum antiprotozoal atovaquone avian malaria efficacy safety proguanil info:eu-repo/semantics/article 2023 ftunivbari https://doi.org/10.3390/ani13223457 2024-04-11T00:09:04Z Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the areas covered by their mosquito vectors, may pose new risks for avian species lacking natural resistance (especially those from artic or sub-artic environments) or those hosted in structures like zoos and wildlife rescue centers. With that premise, this study describes the efficacy and safety of a therapeutic protocol to treat avian malaria in three snowy owls (Bubo scandiacus) hosted in a wildlife rescue center in Apulia, south of Italy, and affected by avian malaria by P. relictum. The protocol consisted of administering 10/4 mg/kg atovaquone/proguanil per os once a day for three consecutive days, repeating this seven days later. Seven days after the end of the treatment, P. relictum was not detected in the birds' blood and no adverse effects were observed during the 60 days of monitoring after the end of the treatment. Therefore, a therapeutic regimen of 10/4 mg/kg/day may be considered safe and effective in a valuable and endangered species such as B. scandiacus. Article in Journal/Newspaper Bubo scandiacus snowy owl Università degli Studi di Bari Aldo Moro: CINECA IRIS Animals 13 22 3457 |
institution |
Open Polar |
collection |
Università degli Studi di Bari Aldo Moro: CINECA IRIS |
op_collection_id |
ftunivbari |
language |
English |
topic |
Bubo scandiacus Plasmodium relictum antiprotozoal atovaquone avian malaria efficacy safety proguanil |
spellingShingle |
Bubo scandiacus Plasmodium relictum antiprotozoal atovaquone avian malaria efficacy safety proguanil Nicola Pugliese Rossella Samarelli Roberto Lombardi Antonella Schiavone Giuseppe Crescenzo Elena Circella Claudia Zizzadoro Olimpia Lai Medhat S. Saleh Michela Prioletti Antonio Camarda A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) |
topic_facet |
Bubo scandiacus Plasmodium relictum antiprotozoal atovaquone avian malaria efficacy safety proguanil |
description |
Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the areas covered by their mosquito vectors, may pose new risks for avian species lacking natural resistance (especially those from artic or sub-artic environments) or those hosted in structures like zoos and wildlife rescue centers. With that premise, this study describes the efficacy and safety of a therapeutic protocol to treat avian malaria in three snowy owls (Bubo scandiacus) hosted in a wildlife rescue center in Apulia, south of Italy, and affected by avian malaria by P. relictum. The protocol consisted of administering 10/4 mg/kg atovaquone/proguanil per os once a day for three consecutive days, repeating this seven days later. Seven days after the end of the treatment, P. relictum was not detected in the birds' blood and no adverse effects were observed during the 60 days of monitoring after the end of the treatment. Therefore, a therapeutic regimen of 10/4 mg/kg/day may be considered safe and effective in a valuable and endangered species such as B. scandiacus. |
author2 |
Pugliese, Nicola Samarelli, Rossella Lombardi, Roberto Schiavone, Antonella Crescenzo, Giuseppe Circella, Elena Zizzadoro, Claudia Lai, Olimpia Saleh, Medhat S. Prioletti, Michela Camarda, Antonio |
format |
Article in Journal/Newspaper |
author |
Nicola Pugliese Rossella Samarelli Roberto Lombardi Antonella Schiavone Giuseppe Crescenzo Elena Circella Claudia Zizzadoro Olimpia Lai Medhat S. Saleh Michela Prioletti Antonio Camarda |
author_facet |
Nicola Pugliese Rossella Samarelli Roberto Lombardi Antonella Schiavone Giuseppe Crescenzo Elena Circella Claudia Zizzadoro Olimpia Lai Medhat S. Saleh Michela Prioletti Antonio Camarda |
author_sort |
Nicola Pugliese |
title |
A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) |
title_short |
A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) |
title_full |
A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) |
title_fullStr |
A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) |
title_full_unstemmed |
A safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian Malaria by Plasmodium relictum in snowy owl (Bubo scandiacus) |
title_sort |
safe and effective atovaquone-proguanil therapeutic protocol for the treatment of avian malaria by plasmodium relictum in snowy owl (bubo scandiacus) |
publishDate |
2023 |
url |
https://hdl.handle.net/11586/453782 https://doi.org/10.3390/ani13223457 https://www.mdpi.com/2076-2615/13/22/3457 |
genre |
Bubo scandiacus snowy owl |
genre_facet |
Bubo scandiacus snowy owl |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/38003076 info:eu-repo/semantics/altIdentifier/wos/WOS:001109552000001 volume:13 issue:22 firstpage:3457 numberofpages:10 journal:ANIMALS https://hdl.handle.net/11586/453782 doi:10.3390/ani13223457 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85178371846 https://www.mdpi.com/2076-2615/13/22/3457 |
op_doi |
https://doi.org/10.3390/ani13223457 |
container_title |
Animals |
container_volume |
13 |
container_issue |
22 |
container_start_page |
3457 |
_version_ |
1796939923934150656 |