Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy
Canine distemper virus (CDV) is a highly contagious viral pathogen causing lethal disease in dogs and other mammalians. A high degree of genetic variation is found between recent CDV strains and the old CDV isolates used in the vaccines and such genetic variation is regarded as a possible cause of t...
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ftunivbari:oai:ricerca.uniba.it:11586/121358 2024-04-14T08:08:08+00:00 Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy MARTELLA, Vito CIRONE, Francesco ELIA, Gabriella LORUSSO, ELEONORA DECARO, Nicola CAMPOLO, MARCO DESARIO, COSTANTINA LUCENTE, MARIA STELLA BELLACICCO, ANNA LUCIA BUONAVOGLIA, Canio BLIXENKRONE MLLER, M Carmichael, L. E Martella, Vito Cirone, Francesco Elia, Gabriella Lorusso, Eleonora Decaro, Nicola Campolo, Marco Desario, Costantina Lucente, MARIA STELLA Bellacicco, ANNA LUCIA BLIXENKRONE MLLER, M Carmichael, L. E Buonavoglia, Canio 2006 http://hdl.handle.net/11586/121358 eng eng info:eu-repo/semantics/altIdentifier/wos/000240244300006 volume:116 firstpage:301 lastpage:309 numberofpages:9 journal:VETERINARY MICROBIOLOGY http://hdl.handle.net/11586/121358 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33747098167 info:eu-repo/semantics/article 2006 ftunivbari 2024-03-28T01:19:05Z Canine distemper virus (CDV) is a highly contagious viral pathogen causing lethal disease in dogs and other mammalians. A high degree of genetic variation is found between recent CDV strains and the old CDV isolates used in the vaccines and such genetic variation is regarded as a possible cause of the increasing number of CDV-related diseases in dogs. The H gene shows the greatest extent of genetic variation that allows for distinction of various lineages, according to a geographical pattern of distribution and irrespective of the species of identification. In the present study, hemagglutinin (H) genes obtained from field strains detected from clinical specimens of Italian dogs were analyzed genetically. Phylogenetic analysis revealed that a homogeneous group of CDV strains is widespread in Italian dogs, all which are included into the European lineage. Unexpectedly, strains 179/04 and 48/05 clustered along with CDVs of the Arctic lineage, the highest identity being to strain GR88 (98.0 and 98.4% aa, respectively). The full-length sequence of a red fox CDV strain, 207/00 was also determined and analyzed. The H protein of the fox CDV strain was unrelated to strains within the major European lineage. These results suggest that at least three different CDV lineages are present in Italy. Article in Journal/Newspaper Arctic Università degli Studi di Bari Aldo Moro: CINECA IRIS Arctic |
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Università degli Studi di Bari Aldo Moro: CINECA IRIS |
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English |
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Canine distemper virus (CDV) is a highly contagious viral pathogen causing lethal disease in dogs and other mammalians. A high degree of genetic variation is found between recent CDV strains and the old CDV isolates used in the vaccines and such genetic variation is regarded as a possible cause of the increasing number of CDV-related diseases in dogs. The H gene shows the greatest extent of genetic variation that allows for distinction of various lineages, according to a geographical pattern of distribution and irrespective of the species of identification. In the present study, hemagglutinin (H) genes obtained from field strains detected from clinical specimens of Italian dogs were analyzed genetically. Phylogenetic analysis revealed that a homogeneous group of CDV strains is widespread in Italian dogs, all which are included into the European lineage. Unexpectedly, strains 179/04 and 48/05 clustered along with CDVs of the Arctic lineage, the highest identity being to strain GR88 (98.0 and 98.4% aa, respectively). The full-length sequence of a red fox CDV strain, 207/00 was also determined and analyzed. The H protein of the fox CDV strain was unrelated to strains within the major European lineage. These results suggest that at least three different CDV lineages are present in Italy. |
author2 |
Martella, Vito Cirone, Francesco Elia, Gabriella Lorusso, Eleonora Decaro, Nicola Campolo, Marco Desario, Costantina Lucente, MARIA STELLA Bellacicco, ANNA LUCIA BLIXENKRONE MLLER, M Carmichael, L. E Buonavoglia, Canio |
format |
Article in Journal/Newspaper |
author |
MARTELLA, Vito CIRONE, Francesco ELIA, Gabriella LORUSSO, ELEONORA DECARO, Nicola CAMPOLO, MARCO DESARIO, COSTANTINA LUCENTE, MARIA STELLA BELLACICCO, ANNA LUCIA BUONAVOGLIA, Canio BLIXENKRONE MLLER, M Carmichael, L. E |
spellingShingle |
MARTELLA, Vito CIRONE, Francesco ELIA, Gabriella LORUSSO, ELEONORA DECARO, Nicola CAMPOLO, MARCO DESARIO, COSTANTINA LUCENTE, MARIA STELLA BELLACICCO, ANNA LUCIA BUONAVOGLIA, Canio BLIXENKRONE MLLER, M Carmichael, L. E Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy |
author_facet |
MARTELLA, Vito CIRONE, Francesco ELIA, Gabriella LORUSSO, ELEONORA DECARO, Nicola CAMPOLO, MARCO DESARIO, COSTANTINA LUCENTE, MARIA STELLA BELLACICCO, ANNA LUCIA BUONAVOGLIA, Canio BLIXENKRONE MLLER, M Carmichael, L. E |
author_sort |
MARTELLA, Vito |
title |
Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy |
title_short |
Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy |
title_full |
Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy |
title_fullStr |
Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy |
title_full_unstemmed |
Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy |
title_sort |
heterogeneity within the hemagglutinin genes of canine distemper virus (cdv) strains detected in italy |
publishDate |
2006 |
url |
http://hdl.handle.net/11586/121358 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/000240244300006 volume:116 firstpage:301 lastpage:309 numberofpages:9 journal:VETERINARY MICROBIOLOGY http://hdl.handle.net/11586/121358 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33747098167 |
_version_ |
1796305567865634816 |