Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone
The asymmetric synthesis of (-)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435 (R) as the key step. (C) 2008 Elsevier Ltd. All rights reserved.
Published in: | Tetrahedron |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
PERGAMON-ELSEVIER SCIENCE LTD
2008
|
Subjects: | |
Online Access: | http://hdl.handle.net/2292/8081 https://doi.org/10.1016/j.tet.2008.01.112 |
Summary: | The asymmetric synthesis of (-)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435 (R) as the key step. (C) 2008 Elsevier Ltd. All rights reserved. |
---|