How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins
Antarctic fishes survive freezing through the secretion of antifreeze glycoproteins (AFGPs), which bind to ice crystals to inhibit their growth. This mode of action implies that ice crystals must be present internally for AFGPs to function. The entry and internal accumulation of ice is likely to be...
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Language: | English |
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CAMBRIDGE UNIV PRESS
2011
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Online Access: | http://hdl.handle.net/2292/7975 https://doi.org/10.1017/S0954102010000635 |
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ftunivauckland:oai:researchspace.auckland.ac.nz:2292/7975 2023-05-15T13:59:29+02:00 How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins Evans, CW Gubala, V Nooney, R Williams, DE Brimble, MA Devries, AL 2011 http://hdl.handle.net/2292/7975 https://doi.org/10.1017/S0954102010000635 EN eng CAMBRIDGE UNIV PRESS ANTARCT SCI Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0954-1020/ https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm Copyright: 2011 Antarctic Science Ltd http://purl.org/eprint/accessRights/RestrictedAccess http://dx.doi.org/10.1017/S0954102010000635 AFGP nanoparticles notothenioid Pagothenia borchgrevinki phagocytosis FREEZING RESISTANCE GLYCOPEPTIDES AVOIDANCE MECHANISM Journal Article 2011 ftunivauckland https://doi.org/10.1017/S0954102010000635 2013-01-22T00:19:47Z Antarctic fishes survive freezing through the secretion of antifreeze glycoproteins (AFGPs), which bind to ice crystals to inhibit their growth. This mode of action implies that ice crystals must be present internally for AFGPs to function. The entry and internal accumulation of ice is likely to be lethal, however, so how do fishes survive in its presence? We propose a novel function for the interaction between internal ice and AFGPs, namely the promotion of ice uptake by splenic phagocytes. We show here that i) external mucus of Antarctic notothenioids contains AFGPs and thus has a potential protective role against ice entry, ii) AFGPs are distributed widely through the extracellular space ensuring that they are likely to come into immediate contact with ice that penetrates their protective barriers, and iii) using AFGP-coated nanoparticles as a proxy for AFGP adsorbed onto ice, we suggest that internal ice crystals are removed from the circulation through phagocytosis, primarily in the spleen. We argue that intracellular sequestration in the spleen minimizes the risks associated with circulating ice and enables the fish to store the ice until it can be dealt with at a later date, possibly by melting during a seasonal warming event. Article in Journal/Newspaper Antarc* Antarctic University of Auckland Research Repository - ResearchSpace Antarctic Antarctic Science 23 1 57 64 |
institution |
Open Polar |
collection |
University of Auckland Research Repository - ResearchSpace |
op_collection_id |
ftunivauckland |
language |
English |
topic |
AFGP nanoparticles notothenioid Pagothenia borchgrevinki phagocytosis FREEZING RESISTANCE GLYCOPEPTIDES AVOIDANCE MECHANISM |
spellingShingle |
AFGP nanoparticles notothenioid Pagothenia borchgrevinki phagocytosis FREEZING RESISTANCE GLYCOPEPTIDES AVOIDANCE MECHANISM Evans, CW Gubala, V Nooney, R Williams, DE Brimble, MA Devries, AL How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins |
topic_facet |
AFGP nanoparticles notothenioid Pagothenia borchgrevinki phagocytosis FREEZING RESISTANCE GLYCOPEPTIDES AVOIDANCE MECHANISM |
description |
Antarctic fishes survive freezing through the secretion of antifreeze glycoproteins (AFGPs), which bind to ice crystals to inhibit their growth. This mode of action implies that ice crystals must be present internally for AFGPs to function. The entry and internal accumulation of ice is likely to be lethal, however, so how do fishes survive in its presence? We propose a novel function for the interaction between internal ice and AFGPs, namely the promotion of ice uptake by splenic phagocytes. We show here that i) external mucus of Antarctic notothenioids contains AFGPs and thus has a potential protective role against ice entry, ii) AFGPs are distributed widely through the extracellular space ensuring that they are likely to come into immediate contact with ice that penetrates their protective barriers, and iii) using AFGP-coated nanoparticles as a proxy for AFGP adsorbed onto ice, we suggest that internal ice crystals are removed from the circulation through phagocytosis, primarily in the spleen. We argue that intracellular sequestration in the spleen minimizes the risks associated with circulating ice and enables the fish to store the ice until it can be dealt with at a later date, possibly by melting during a seasonal warming event. |
format |
Article in Journal/Newspaper |
author |
Evans, CW Gubala, V Nooney, R Williams, DE Brimble, MA Devries, AL |
author_facet |
Evans, CW Gubala, V Nooney, R Williams, DE Brimble, MA Devries, AL |
author_sort |
Evans, CW |
title |
How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins |
title_short |
How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins |
title_full |
How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins |
title_fullStr |
How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins |
title_full_unstemmed |
How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins |
title_sort |
how do antarctic notothenioid fishes cope with internal ice? a novel function for antifreeze glycoproteins |
publisher |
CAMBRIDGE UNIV PRESS |
publishDate |
2011 |
url |
http://hdl.handle.net/2292/7975 https://doi.org/10.1017/S0954102010000635 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
http://dx.doi.org/10.1017/S0954102010000635 |
op_relation |
ANTARCT SCI |
op_rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0954-1020/ https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm Copyright: 2011 Antarctic Science Ltd http://purl.org/eprint/accessRights/RestrictedAccess |
op_doi |
https://doi.org/10.1017/S0954102010000635 |
container_title |
Antarctic Science |
container_volume |
23 |
container_issue |
1 |
container_start_page |
57 |
op_container_end_page |
64 |
_version_ |
1766268058130710528 |