Effects of fluorodeoxyglucose magnetic nanoparticles on NCIH727 and SH-SY5Y cancer cells

• Published in: Asian Journal of Nanoscience and Materials
• Main Authors: Unak, Perihan, Budiyo, Rumbidzai Cheryl, Horsnzky, Alex, Yasakci, Volkan, Pearce, Gillian, Russell, Steve, Aras, Omer, Akin, Oguz, Wong, Julian
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2021
• Subjects: sami
• Online Access: https://doi.org/10.26655/AJNANOMAT.2021.1.5; https://publications.aston.ac.uk/id/eprint/42276/; https://publications.aston.ac.uk/id/eprint/42276/1/AJNM_Volume_4_Issue_1_Pages_53_66.pdf

We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells. © 2021 by SPC (Sami Publishing Company), Asian Journal of Nanoscience and Materials, Reproduction is permitted for noncommercial purposes.