Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings
Abstract: Raptors are exposed to biomagnifying and toxic organohalogenated compounds (OHCs) such as organochlorines, brominated flame retardants and perfluorinated compounds. To investigate how OHC exposure may affect biochemical pathways we collected blood plasma from Norwegian northern goshawk (n=...
Published in: | Ecotoxicology and Environmental Safety |
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Language: | English |
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2012
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Online Access: | https://hdl.handle.net/10067/975930151162165141 |
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ftunivantwerpen:c:irua:97593 2024-10-06T13:51:29+00:00 Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings Sonne, Christian Bustnes, Jan O. Herzke, Dorte Jaspers, Veerle Covaci, Adrian Eulaers, Igor Eens, Marcel 2012 https://hdl.handle.net/10067/975930151162165141 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1016/J.ECOENV.2012.02.012 info:eu-repo/semantics/altIdentifier/isi/000304337300011 info:eu-repo/semantics/closedAccess 0147-6513 Ecotoxicology and environmental safety Chemistry Biology Pharmacology. Therapy info:eu-repo/semantics/article 2012 ftunivantwerpen https://doi.org/10.1016/J.ECOENV.2012.02.012 2024-09-10T04:06:33Z Abstract: Raptors are exposed to biomagnifying and toxic organohalogenated compounds (OHCs) such as organochlorines, brominated flame retardants and perfluorinated compounds. To investigate how OHC exposure may affect biochemical pathways we collected blood plasma from Norwegian northern goshawk (n=56), golden eagle (n=12) and white-tailed eagle (n=36) nestlings during three consecutive breeding seasons. We found that blood plasma concentrations of calcium, sodium, creatinine, cholesterol, albumin, total protein, urea, inorganic phosphate, protein:creatinine, urea:creatinine and uric acid:creatinine ratios and liver enzymes ALKP and ALAT were positively correlated to PCBs, chlordanes, p,p′-DDE, HCB, PFCs and/or PBDEs. Total bilirubin and glucose were negatively correlated to PCBs while magnesium and potassium were negatively correlated to HCB and p,p′-DDE. In addition, protein:creatinine and ALAT were also negatively correlated to PCBs and PFCs, respectively. The most significant relationships were found for the highly contaminated northern goshawks and white-tailed eagles. The statistical relationships between OHCs and BCCPs indicate that biochemical pathways could be influenced while it is uncertain if such changes have any health effects. The OHC concentrations were below concentrations causing reproductive toxicity in adults of other raptor species but similar to those of concern for endocrine disruption of thyroid hormones in e.g., bald eagles. Article in Journal/Newspaper Northern Goshawk White-tailed eagle golden eagle IRUA - Institutional Repository van de Universiteit Antwerpen Ecotoxicology and Environmental Safety 80 76 83 |
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Open Polar |
collection |
IRUA - Institutional Repository van de Universiteit Antwerpen |
op_collection_id |
ftunivantwerpen |
language |
English |
topic |
Chemistry Biology Pharmacology. Therapy |
spellingShingle |
Chemistry Biology Pharmacology. Therapy Sonne, Christian Bustnes, Jan O. Herzke, Dorte Jaspers, Veerle Covaci, Adrian Eulaers, Igor Eens, Marcel Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings |
topic_facet |
Chemistry Biology Pharmacology. Therapy |
description |
Abstract: Raptors are exposed to biomagnifying and toxic organohalogenated compounds (OHCs) such as organochlorines, brominated flame retardants and perfluorinated compounds. To investigate how OHC exposure may affect biochemical pathways we collected blood plasma from Norwegian northern goshawk (n=56), golden eagle (n=12) and white-tailed eagle (n=36) nestlings during three consecutive breeding seasons. We found that blood plasma concentrations of calcium, sodium, creatinine, cholesterol, albumin, total protein, urea, inorganic phosphate, protein:creatinine, urea:creatinine and uric acid:creatinine ratios and liver enzymes ALKP and ALAT were positively correlated to PCBs, chlordanes, p,p′-DDE, HCB, PFCs and/or PBDEs. Total bilirubin and glucose were negatively correlated to PCBs while magnesium and potassium were negatively correlated to HCB and p,p′-DDE. In addition, protein:creatinine and ALAT were also negatively correlated to PCBs and PFCs, respectively. The most significant relationships were found for the highly contaminated northern goshawks and white-tailed eagles. The statistical relationships between OHCs and BCCPs indicate that biochemical pathways could be influenced while it is uncertain if such changes have any health effects. The OHC concentrations were below concentrations causing reproductive toxicity in adults of other raptor species but similar to those of concern for endocrine disruption of thyroid hormones in e.g., bald eagles. |
format |
Article in Journal/Newspaper |
author |
Sonne, Christian Bustnes, Jan O. Herzke, Dorte Jaspers, Veerle Covaci, Adrian Eulaers, Igor Eens, Marcel |
author_facet |
Sonne, Christian Bustnes, Jan O. Herzke, Dorte Jaspers, Veerle Covaci, Adrian Eulaers, Igor Eens, Marcel |
author_sort |
Sonne, Christian |
title |
Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings |
title_short |
Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings |
title_full |
Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings |
title_fullStr |
Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings |
title_full_unstemmed |
Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings |
title_sort |
blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in norwegian raptor nestlings |
publishDate |
2012 |
url |
https://hdl.handle.net/10067/975930151162165141 |
genre |
Northern Goshawk White-tailed eagle golden eagle |
genre_facet |
Northern Goshawk White-tailed eagle golden eagle |
op_source |
0147-6513 Ecotoxicology and environmental safety |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/J.ECOENV.2012.02.012 info:eu-repo/semantics/altIdentifier/isi/000304337300011 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/J.ECOENV.2012.02.012 |
container_title |
Ecotoxicology and Environmental Safety |
container_volume |
80 |
container_start_page |
76 |
op_container_end_page |
83 |
_version_ |
1812179713817313280 |