Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management
Abstract: Hexabromocyclododecane (HBCD) is a globally produced brominated flame retardant (BFR) used primarily as an additive FR in polystyrene and textile products and has been the subject of intensified research, monitoring and regulatory interest over the past decade. HBCD is currently being eval...
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ftunivantwerpen:c:irua:93584 2024-10-06T13:46:47+00:00 Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management Marvin, Christopher H. Tomy, Gregg T. Armitage, James M. Arnot, Jon A. NcCarty, Lynn Covaci, Adrian Palace, Vince 2011 https://hdl.handle.net/10067/935840151162165141 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1021/ES201548C info:eu-repo/semantics/altIdentifier/isi/000295704500006 info:eu-repo/semantics/closedAccess 0013-936X Environmental science and technology Biology Engineering sciences. Technology info:eu-repo/semantics/article 2011 ftunivantwerpen https://doi.org/10.1021/ES201548C 2024-09-10T04:06:32Z Abstract: Hexabromocyclododecane (HBCD) is a globally produced brominated flame retardant (BFR) used primarily as an additive FR in polystyrene and textile products and has been the subject of intensified research, monitoring and regulatory interest over the past decade. HBCD is currently being evaluated under the Stockholm Convention on Persistent Organic Pollutants. HBCD is hydrophobic (i.e., has low water solubility) and thus partitions to organic phases in the aquatic environment (e.g., lipids, suspended solids). It is ubiquitous in the global environment with monitoring data generally exhibiting the expected relationship between proximity to known sources and levels; however, temporal trends are not consistent. Estimated degradation half-lives, together with data in abiotic compartments and long-range transport potential indicate HBCD may be sufficiently persistent and distributed to be of global concern. The detection of HBCD in biota in the Arctic and in source regions and available bioaccumulation data also support the case for regulatory scrutiny. Toxicity testing has detected reproductive, developmental and behavioral effects in animals where exposures are sufficient. Recent toxicological advances include a better mechanistic understanding of how HBCD can interfere with the hypothalamic-pituitary-thyroid axis, affect normal development, and impact the central nervous system; however, levels in biota in remote locations are below known effects thresholds. For many regulatory criteria, there are substantial uncertainties that reduce confidence in evaluations and thereby confound management decision-making based on currently available information. Article in Journal/Newspaper Arctic IRUA - Institutional Repository van de Universiteit Antwerpen Arctic Environmental Science & Technology 45 20 8613 8623 |
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Open Polar |
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IRUA - Institutional Repository van de Universiteit Antwerpen |
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ftunivantwerpen |
language |
English |
topic |
Biology Engineering sciences. Technology |
spellingShingle |
Biology Engineering sciences. Technology Marvin, Christopher H. Tomy, Gregg T. Armitage, James M. Arnot, Jon A. NcCarty, Lynn Covaci, Adrian Palace, Vince Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
topic_facet |
Biology Engineering sciences. Technology |
description |
Abstract: Hexabromocyclododecane (HBCD) is a globally produced brominated flame retardant (BFR) used primarily as an additive FR in polystyrene and textile products and has been the subject of intensified research, monitoring and regulatory interest over the past decade. HBCD is currently being evaluated under the Stockholm Convention on Persistent Organic Pollutants. HBCD is hydrophobic (i.e., has low water solubility) and thus partitions to organic phases in the aquatic environment (e.g., lipids, suspended solids). It is ubiquitous in the global environment with monitoring data generally exhibiting the expected relationship between proximity to known sources and levels; however, temporal trends are not consistent. Estimated degradation half-lives, together with data in abiotic compartments and long-range transport potential indicate HBCD may be sufficiently persistent and distributed to be of global concern. The detection of HBCD in biota in the Arctic and in source regions and available bioaccumulation data also support the case for regulatory scrutiny. Toxicity testing has detected reproductive, developmental and behavioral effects in animals where exposures are sufficient. Recent toxicological advances include a better mechanistic understanding of how HBCD can interfere with the hypothalamic-pituitary-thyroid axis, affect normal development, and impact the central nervous system; however, levels in biota in remote locations are below known effects thresholds. For many regulatory criteria, there are substantial uncertainties that reduce confidence in evaluations and thereby confound management decision-making based on currently available information. |
format |
Article in Journal/Newspaper |
author |
Marvin, Christopher H. Tomy, Gregg T. Armitage, James M. Arnot, Jon A. NcCarty, Lynn Covaci, Adrian Palace, Vince |
author_facet |
Marvin, Christopher H. Tomy, Gregg T. Armitage, James M. Arnot, Jon A. NcCarty, Lynn Covaci, Adrian Palace, Vince |
author_sort |
Marvin, Christopher H. |
title |
Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
title_short |
Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
title_full |
Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
title_fullStr |
Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
title_full_unstemmed |
Hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
title_sort |
hexabromocyclododecane : current understanding of chemistry, environmental fate and toxicology and implications for global management |
publishDate |
2011 |
url |
https://hdl.handle.net/10067/935840151162165141 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
0013-936X Environmental science and technology |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1021/ES201548C info:eu-repo/semantics/altIdentifier/isi/000295704500006 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1021/ES201548C |
container_title |
Environmental Science & Technology |
container_volume |
45 |
container_issue |
20 |
container_start_page |
8613 |
op_container_end_page |
8623 |
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1812175106126905344 |