Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease
Abstract: Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding...
Published in: | Neurobiology of Aging |
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Language: | English |
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2005
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ftunivantwerpen:c:irua:54647 2023-07-16T04:00:09+02:00 Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease Rademakers, Rosa Sleegers, Kristel Theuns, Jessie Van den Broeck, Marleen Bel Kacem, S. Nilsson, L.-G. Adolfsson, R. van Duijn, C.M. Van Broeckhoven, Christine Cruts, Marc 2005 https://hdl.handle.net/10067/546470151162165141 eng eng info:eu-repo/semantics/altIdentifier/isi/000229816900002 info:eu-repo/semantics/altIdentifier/doi/10.1016/J.NEUROBIOLAGING.2004.10.003 info:eu-repo/semantics/closedAccess 0197-4580 Neurobiology of aging Human medicine info:eu-repo/semantics/article 2005 ftunivantwerpen https://doi.org/10.1016/J.NEUROBIOLAGING.2004.10.003 2023-06-26T22:12:17Z Abstract: Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding CDK5 (CDK5), p35 (CDK5RI) and p39 (CDK5R2), we excluded causal mutations in 70 familial early-onset AD patients. We performed an association study with five informative SNPs in CDK5 in two independent samples of early-onset AD patients and matched control individuals from The Netherlands and northern Sweden. Association was observed with g.149800G > C in intron 5 of CDK5, and a two times increased risk was observed in both patient samples for carriers of the C-allele. Our data are indicative for a role of the CDK5 molecular complex in the genetic etiology of early-onset AD, and suggest that a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset AD. (c) 2004 Elsevier Inc. All rights reserved. Article in Journal/Newspaper Northern Sweden IRUA - Institutional Repository van de Universiteit Antwerpen Neurobiology of Aging 26 8 1145 1151 |
institution |
Open Polar |
collection |
IRUA - Institutional Repository van de Universiteit Antwerpen |
op_collection_id |
ftunivantwerpen |
language |
English |
topic |
Human medicine |
spellingShingle |
Human medicine Rademakers, Rosa Sleegers, Kristel Theuns, Jessie Van den Broeck, Marleen Bel Kacem, S. Nilsson, L.-G. Adolfsson, R. van Duijn, C.M. Van Broeckhoven, Christine Cruts, Marc Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease |
topic_facet |
Human medicine |
description |
Abstract: Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding CDK5 (CDK5), p35 (CDK5RI) and p39 (CDK5R2), we excluded causal mutations in 70 familial early-onset AD patients. We performed an association study with five informative SNPs in CDK5 in two independent samples of early-onset AD patients and matched control individuals from The Netherlands and northern Sweden. Association was observed with g.149800G > C in intron 5 of CDK5, and a two times increased risk was observed in both patient samples for carriers of the C-allele. Our data are indicative for a role of the CDK5 molecular complex in the genetic etiology of early-onset AD, and suggest that a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset AD. (c) 2004 Elsevier Inc. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Rademakers, Rosa Sleegers, Kristel Theuns, Jessie Van den Broeck, Marleen Bel Kacem, S. Nilsson, L.-G. Adolfsson, R. van Duijn, C.M. Van Broeckhoven, Christine Cruts, Marc |
author_facet |
Rademakers, Rosa Sleegers, Kristel Theuns, Jessie Van den Broeck, Marleen Bel Kacem, S. Nilsson, L.-G. Adolfsson, R. van Duijn, C.M. Van Broeckhoven, Christine Cruts, Marc |
author_sort |
Rademakers, Rosa |
title |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease |
title_short |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease |
title_full |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease |
title_fullStr |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease |
title_full_unstemmed |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease |
title_sort |
association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset alzheimer's disease |
publishDate |
2005 |
url |
https://hdl.handle.net/10067/546470151162165141 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
0197-4580 Neurobiology of aging |
op_relation |
info:eu-repo/semantics/altIdentifier/isi/000229816900002 info:eu-repo/semantics/altIdentifier/doi/10.1016/J.NEUROBIOLAGING.2004.10.003 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/J.NEUROBIOLAGING.2004.10.003 |
container_title |
Neurobiology of Aging |
container_volume |
26 |
container_issue |
8 |
container_start_page |
1145 |
op_container_end_page |
1151 |
_version_ |
1771548702994857984 |