Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers : results from the "European Human Biomonitoring Initiative" HBM4EU participating studies

• Published in: Scientific Reports
• Main Authors: F. Fernandez, Sandra, Poteser, Michael, Govarts, Eva, Pardo, Olga, Coscolla, Clara, Schettgen, Thomas, Vogel, Nina, Weber, Till, Murawski, Aline, Kolossa-Gehring, Marike, Ruether, Maria, Schmidt, Phillipp, Namorado, Sonia, Van Nieuwenhuyse, An, Appenzeller, Brice, Olafsdottir, Kristin, Halldorsson, Thorhallur I., Haug, Line S., Thomsen, Cathrine, Barbone, Fabio, Mariuz, Marika, Rosolen, Valentina, Rambaud, Loic, Riou, Margaux, Goeen, Thomas, Nuebler, Stefanie, Schaefer, Moritz, Zarrabi, Karin H.A., Sepai, Ovnair, Martin, Laura Rodriguez, Schoeters, Greet, Gilles, Liese, Leander, Karin, Moshammer, Hanns, Akesson, Agneta, Federica, Laguzzi
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2023
• Subjects: Human medicine; Iceland
• Online Access: https://hdl.handle.net/10067/2039040151162165141; https://repository.uantwerpen.be/docstore/d:irua:22347

Abstract: Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014-2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3-18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20-45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (beta coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (mu g/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:beta = - 9.1 mu g/g creatinine, 95% CI - 15.8, - 2.4; GAMA: beta = - 3.4 mu g/g creatinine, 95% CI - 4.7, - 2.2), living in rural areas (AAMA:beta = - 4.7 mu g/g creatinine, 95% CI - 8.6, - 0.8; GAMA:beta = - 1.1 mu g/g creatinine, 95% CI - 1.9, - 0.4) and increasing age (AAMA:beta = - 1.9 mu g/g creatinine, 95% CI - 2.4, - 1.4; GAMA:beta = - 0.7 mu g/g creatinine, 95% CI - 0.8, - 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries.