Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults
Abstract: Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET...
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ftunivantwerpen:c:irua:191586 2023-07-16T03:59:12+02:00 Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loic Riou, Margaux Halldorsson, Thorhallur, I Olafsdottir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-Lopez, Marta Castano, Argelia Andersen, Helle Raun Schoeters, Greet 2022 https://hdl.handle.net/10067/1915860151162165141 https://repository.uantwerpen.be/docstore/d:irua:14890 eng eng info:eu-repo/semantics/altIdentifier/doi/10.3390/TOXICS10100552 info:eu-repo/semantics/altIdentifier/isi/000873828700001 info:eu-repo/semantics/openAccess 2305-6304 Toxics Chemistry Biology Pharmacology. Therapy info:eu-repo/semantics/article 2022 ftunivantwerpen https://doi.org/10.3390/TOXICS10100552 2023-06-26T22:36:20Z Abstract: Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019-2020); ESTEBAN France (2014-2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05-0.1 mu g/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 mu g/L urine for Gly and between 0.21 and 0.38 mu g/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. Article in Journal/Newspaper Iceland IRUA - Institutional Repository van de Universiteit Antwerpen Toxics 10 10 552 |
institution |
Open Polar |
collection |
IRUA - Institutional Repository van de Universiteit Antwerpen |
op_collection_id |
ftunivantwerpen |
language |
English |
topic |
Chemistry Biology Pharmacology. Therapy |
spellingShingle |
Chemistry Biology Pharmacology. Therapy Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loic Riou, Margaux Halldorsson, Thorhallur, I Olafsdottir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-Lopez, Marta Castano, Argelia Andersen, Helle Raun Schoeters, Greet Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults |
topic_facet |
Chemistry Biology Pharmacology. Therapy |
description |
Abstract: Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019-2020); ESTEBAN France (2014-2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05-0.1 mu g/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 mu g/L urine for Gly and between 0.21 and 0.38 mu g/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. |
format |
Article in Journal/Newspaper |
author |
Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loic Riou, Margaux Halldorsson, Thorhallur, I Olafsdottir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-Lopez, Marta Castano, Argelia Andersen, Helle Raun Schoeters, Greet |
author_facet |
Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loic Riou, Margaux Halldorsson, Thorhallur, I Olafsdottir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-Lopez, Marta Castano, Argelia Andersen, Helle Raun Schoeters, Greet |
author_sort |
Buekers, Jurgen |
title |
Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults |
title_short |
Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults |
title_full |
Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults |
title_fullStr |
Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults |
title_full_unstemmed |
Glyphosate and AMPA in human urine of HBM4EU-aligned studies : part B adults |
title_sort |
glyphosate and ampa in human urine of hbm4eu-aligned studies : part b adults |
publishDate |
2022 |
url |
https://hdl.handle.net/10067/1915860151162165141 https://repository.uantwerpen.be/docstore/d:irua:14890 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
2305-6304 Toxics |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.3390/TOXICS10100552 info:eu-repo/semantics/altIdentifier/isi/000873828700001 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/TOXICS10100552 |
container_title |
Toxics |
container_volume |
10 |
container_issue |
10 |
container_start_page |
552 |
_version_ |
1771546744561074176 |