The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

• Published in: Translational Psychiatry
• Main Authors: Szatkiewicz, Jin, Crowley, James J., Adolfsson, Annelie Nordin, Aberg, Karolina A., Alaerts, Maaike, Genovese, Giulio, McCarroll, Steven, Del-Favero, Jurgen, Adolfsson, Rolf, Sullivan, Patrick F.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2019
• Subjects: Human medicine; Northern Sweden
• Online Access: https://hdl.handle.net/10067/1586290151162165141; https://repository.uantwerpen.be/docman/irua/e4faf0/158629.pdf

Abstract: We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.