The Greenland shark : a new challenge for the oxidative stress theory of ageing?
Abstract: The free radical theory of ageing predicts that long-lived species should be more resistant to oxidative damage than short-lived species. Although many studies support this theory, recent studies found notable exceptions that challenge the generality of this theory. In this study, we have...
Published in: | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
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Language: | English |
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Online Access: | https://hdl.handle.net/10067/1403340151162165141 |
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ftunivantwerpen:c:irua:140334 2023-07-16T03:58:41+02:00 The Greenland shark : a new challenge for the oxidative stress theory of ageing? Costantini, David Smith, Shona Killen, Shaun S. Nielsen, Julius Steffensen, John F. 2017 https://hdl.handle.net/10067/1403340151162165141 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1016/J.CBPA.2016.09.026 info:eu-repo/semantics/altIdentifier/isi/000390718800027 info:eu-repo/semantics/closedAccess 1095-6433 Comparative biochemistry and physiology : A : molecular & integrative physiology Chemistry Biology Human medicine info:eu-repo/semantics/article 2017 ftunivantwerpen https://doi.org/10.1016/J.CBPA.2016.09.026 2023-06-26T22:21:29Z Abstract: The free radical theory of ageing predicts that long-lived species should be more resistant to oxidative damage than short-lived species. Although many studies support this theory, recent studies found notable exceptions that challenge the generality of this theory. In this study, we have analysed the oxidative status of the Greenland shark (Somniosus microcephalus), which has recently been found as the longest living vertebrate animal known to science with a lifespan of at least 272 years. As compared to other species, the Greenland shark had body mass corrected values of muscle glutathione peroxidase and red blood cells protein carbonyls (metric of protein oxidative damage) above 75 percentile and below 25 percentile, respectively. None of the biochemical metrics of oxidative status measured in either skeletal muscle or red blood cells were correlated with maximum lifespan of species. We propose that the values of metrics of oxidative status we measured might be linked to ecological features (e.g., adaptation to cold waters and deep dives) of this shark species rather to its lifespan. (C) 2016 Elsevier Inc. All rights reserved. Article in Journal/Newspaper Greenland Somniosus microcephalus IRUA - Institutional Repository van de Universiteit Antwerpen Greenland Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 203 227 232 |
institution |
Open Polar |
collection |
IRUA - Institutional Repository van de Universiteit Antwerpen |
op_collection_id |
ftunivantwerpen |
language |
English |
topic |
Chemistry Biology Human medicine |
spellingShingle |
Chemistry Biology Human medicine Costantini, David Smith, Shona Killen, Shaun S. Nielsen, Julius Steffensen, John F. The Greenland shark : a new challenge for the oxidative stress theory of ageing? |
topic_facet |
Chemistry Biology Human medicine |
description |
Abstract: The free radical theory of ageing predicts that long-lived species should be more resistant to oxidative damage than short-lived species. Although many studies support this theory, recent studies found notable exceptions that challenge the generality of this theory. In this study, we have analysed the oxidative status of the Greenland shark (Somniosus microcephalus), which has recently been found as the longest living vertebrate animal known to science with a lifespan of at least 272 years. As compared to other species, the Greenland shark had body mass corrected values of muscle glutathione peroxidase and red blood cells protein carbonyls (metric of protein oxidative damage) above 75 percentile and below 25 percentile, respectively. None of the biochemical metrics of oxidative status measured in either skeletal muscle or red blood cells were correlated with maximum lifespan of species. We propose that the values of metrics of oxidative status we measured might be linked to ecological features (e.g., adaptation to cold waters and deep dives) of this shark species rather to its lifespan. (C) 2016 Elsevier Inc. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Costantini, David Smith, Shona Killen, Shaun S. Nielsen, Julius Steffensen, John F. |
author_facet |
Costantini, David Smith, Shona Killen, Shaun S. Nielsen, Julius Steffensen, John F. |
author_sort |
Costantini, David |
title |
The Greenland shark : a new challenge for the oxidative stress theory of ageing? |
title_short |
The Greenland shark : a new challenge for the oxidative stress theory of ageing? |
title_full |
The Greenland shark : a new challenge for the oxidative stress theory of ageing? |
title_fullStr |
The Greenland shark : a new challenge for the oxidative stress theory of ageing? |
title_full_unstemmed |
The Greenland shark : a new challenge for the oxidative stress theory of ageing? |
title_sort |
greenland shark : a new challenge for the oxidative stress theory of ageing? |
publishDate |
2017 |
url |
https://hdl.handle.net/10067/1403340151162165141 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland Somniosus microcephalus |
genre_facet |
Greenland Somniosus microcephalus |
op_source |
1095-6433 Comparative biochemistry and physiology : A : molecular & integrative physiology |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/J.CBPA.2016.09.026 info:eu-repo/semantics/altIdentifier/isi/000390718800027 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/J.CBPA.2016.09.026 |
container_title |
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
container_volume |
203 |
container_start_page |
227 |
op_container_end_page |
232 |
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1771545946804453376 |