A network of synaptic genes associated with schizophrenia and bipolar disorder
Abstract: Identification of novel candidate genes for schizophrenia (SZ) and bipolar disorder (BP), two psychiatric disorders with large epidemiological impacts, is a key research area in neurosciences and psychiatric genetics. Previous evidence from genome-wide studies suggests an important role fo...
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Language: | English |
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2016
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Online Access: | https://hdl.handle.net/10067/1332740151162165141 |
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ftunivantwerpen:c:irua:133274 2023-07-16T04:00:09+02:00 A network of synaptic genes associated with schizophrenia and bipolar disorder Forero, Diego Herteleer, Liesbet De Zutter, Sonia Norrback, Karl-Fredrik Nilsson, Lars-Goran Adolfsson, Rolf Callaerts, Patrick Del-Favero, Jurgen 2016 https://hdl.handle.net/10067/1332740151162165141 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1016/J.SCHRES.2016.02.012 info:eu-repo/semantics/altIdentifier/isi/000373528100011 info:eu-repo/semantics/closedAccess 0920-9964 Schizophrenia research Human medicine info:eu-repo/semantics/article 2016 ftunivantwerpen https://doi.org/10.1016/J.SCHRES.2016.02.012 2023-06-26T22:20:33Z Abstract: Identification of novel candidate genes for schizophrenia (SZ) and bipolar disorder (BP), two psychiatric disorders with large epidemiological impacts, is a key research area in neurosciences and psychiatric genetics. Previous evidence from genome-wide studies suggests an important role for genes involved in synaptic plasticity in the risk for SZ and BP. We used a convergent genomics approach, combining different lines of biological evidence, to identify genes involved in the cAMP/PKA/CREB functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A. These 7 genes were analyzed in a HapMap based association study comprising 48 common SNPs in 486 SZ, 351 BP patients and 514 control individuals recruited from an isolated population in Northern Sweden. Genetic analysis showed significant allelic associations of SNPs in PRKAR1A with SZ and of PPP3CB and PRKAR1A with BP. Our results highlight the feasibility and the importance of convergent genomic data analysis for the identification of candidate genes and our data provide support for the role of common inherited variants in synaptic genes and their involvement in the etiology of BP and SZ. (C) 2016 Elsevier B.V. All rights reserved. Article in Journal/Newspaper Northern Sweden IRUA - Institutional Repository van de Universiteit Antwerpen Schizophrenia Research 172 1-3 68 74 |
institution |
Open Polar |
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IRUA - Institutional Repository van de Universiteit Antwerpen |
op_collection_id |
ftunivantwerpen |
language |
English |
topic |
Human medicine |
spellingShingle |
Human medicine Forero, Diego Herteleer, Liesbet De Zutter, Sonia Norrback, Karl-Fredrik Nilsson, Lars-Goran Adolfsson, Rolf Callaerts, Patrick Del-Favero, Jurgen A network of synaptic genes associated with schizophrenia and bipolar disorder |
topic_facet |
Human medicine |
description |
Abstract: Identification of novel candidate genes for schizophrenia (SZ) and bipolar disorder (BP), two psychiatric disorders with large epidemiological impacts, is a key research area in neurosciences and psychiatric genetics. Previous evidence from genome-wide studies suggests an important role for genes involved in synaptic plasticity in the risk for SZ and BP. We used a convergent genomics approach, combining different lines of biological evidence, to identify genes involved in the cAMP/PKA/CREB functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A. These 7 genes were analyzed in a HapMap based association study comprising 48 common SNPs in 486 SZ, 351 BP patients and 514 control individuals recruited from an isolated population in Northern Sweden. Genetic analysis showed significant allelic associations of SNPs in PRKAR1A with SZ and of PPP3CB and PRKAR1A with BP. Our results highlight the feasibility and the importance of convergent genomic data analysis for the identification of candidate genes and our data provide support for the role of common inherited variants in synaptic genes and their involvement in the etiology of BP and SZ. (C) 2016 Elsevier B.V. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Forero, Diego Herteleer, Liesbet De Zutter, Sonia Norrback, Karl-Fredrik Nilsson, Lars-Goran Adolfsson, Rolf Callaerts, Patrick Del-Favero, Jurgen |
author_facet |
Forero, Diego Herteleer, Liesbet De Zutter, Sonia Norrback, Karl-Fredrik Nilsson, Lars-Goran Adolfsson, Rolf Callaerts, Patrick Del-Favero, Jurgen |
author_sort |
Forero, Diego |
title |
A network of synaptic genes associated with schizophrenia and bipolar disorder |
title_short |
A network of synaptic genes associated with schizophrenia and bipolar disorder |
title_full |
A network of synaptic genes associated with schizophrenia and bipolar disorder |
title_fullStr |
A network of synaptic genes associated with schizophrenia and bipolar disorder |
title_full_unstemmed |
A network of synaptic genes associated with schizophrenia and bipolar disorder |
title_sort |
network of synaptic genes associated with schizophrenia and bipolar disorder |
publishDate |
2016 |
url |
https://hdl.handle.net/10067/1332740151162165141 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
0920-9964 Schizophrenia research |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/J.SCHRES.2016.02.012 info:eu-repo/semantics/altIdentifier/isi/000373528100011 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/J.SCHRES.2016.02.012 |
container_title |
Schizophrenia Research |
container_volume |
172 |
container_issue |
1-3 |
container_start_page |
68 |
op_container_end_page |
74 |
_version_ |
1771548704302432256 |