Genetic Variation and Population Structure in Native Americans
ABSTRACT: We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar...
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Online Access: | http://hdl.handle.net/10495/23699 https://doi.org/10.1371/journal.pgen.0030185 |
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ftunivantioquia:oai:bibliotecadigital.udea.edu.co:10495/23699 2023-05-15T15:44:14+02:00 Genetic Variation and Population Structure in Native Americans Wang, Sijia Lewis, Cecil Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya Berrío, Gabriel de Jesús Rojas Montoya, Winston Parra Marín, María Victoria Molina, Julio Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco Petzl Erler, Maria Luiza Tsuneto, Luiza Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus Rosenberg, Noah Ruíz Linares, Andrés 2007 19 application/pdf http://hdl.handle.net/10495/23699 https://doi.org/10.1371/journal.pgen.0030185 eng eng Public Library of Science Genética Molecular (GENMOL) San Francisco, Estados Unidos PLoS Genet. Wang, S., Lewis, C., Jakobsson, M., Ramachandran, S., Ray, N., et al (2007) Genetic variation and population structure in Native Americans. PLoS Genet 3(11): e185. doi:10.1371/journal.pgen.0030185 1553-7390 http://hdl.handle.net/10495/23699 doi:10.1371/journal.pgen.0030185 1553-7404 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ CC-BY América del Norte North America Genética de Población Genetics Population Mestizos Racially mixed people info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_2df8fbb1 https://purl.org/redcol/resource_type/ART Artículo de investigación 2007 ftunivantioquia https://doi.org/10.1371/journal.pgen.0030185 2022-12-19T14:22:21Z ABSTRACT: We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. COL0006723 Article in Journal/Newspaper Bering Strait Universidad de Antioquia (UdeA): Institutional Repository Bering Strait PLoS Genetics 3 11 e185 |
institution |
Open Polar |
collection |
Universidad de Antioquia (UdeA): Institutional Repository |
op_collection_id |
ftunivantioquia |
language |
English |
topic |
América del Norte North America Genética de Población Genetics Population Mestizos Racially mixed people |
spellingShingle |
América del Norte North America Genética de Población Genetics Population Mestizos Racially mixed people Wang, Sijia Lewis, Cecil Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya Berrío, Gabriel de Jesús Rojas Montoya, Winston Parra Marín, María Victoria Molina, Julio Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco Petzl Erler, Maria Luiza Tsuneto, Luiza Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus Rosenberg, Noah Ruíz Linares, Andrés Genetic Variation and Population Structure in Native Americans |
topic_facet |
América del Norte North America Genética de Población Genetics Population Mestizos Racially mixed people |
description |
ABSTRACT: We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. COL0006723 |
format |
Article in Journal/Newspaper |
author |
Wang, Sijia Lewis, Cecil Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya Berrío, Gabriel de Jesús Rojas Montoya, Winston Parra Marín, María Victoria Molina, Julio Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco Petzl Erler, Maria Luiza Tsuneto, Luiza Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus Rosenberg, Noah Ruíz Linares, Andrés |
author_facet |
Wang, Sijia Lewis, Cecil Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya Berrío, Gabriel de Jesús Rojas Montoya, Winston Parra Marín, María Victoria Molina, Julio Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco Petzl Erler, Maria Luiza Tsuneto, Luiza Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus Rosenberg, Noah Ruíz Linares, Andrés |
author_sort |
Wang, Sijia |
title |
Genetic Variation and Population Structure in Native Americans |
title_short |
Genetic Variation and Population Structure in Native Americans |
title_full |
Genetic Variation and Population Structure in Native Americans |
title_fullStr |
Genetic Variation and Population Structure in Native Americans |
title_full_unstemmed |
Genetic Variation and Population Structure in Native Americans |
title_sort |
genetic variation and population structure in native americans |
publisher |
Public Library of Science |
publishDate |
2007 |
url |
http://hdl.handle.net/10495/23699 https://doi.org/10.1371/journal.pgen.0030185 |
geographic |
Bering Strait |
geographic_facet |
Bering Strait |
genre |
Bering Strait |
genre_facet |
Bering Strait |
op_relation |
PLoS Genet. Wang, S., Lewis, C., Jakobsson, M., Ramachandran, S., Ray, N., et al (2007) Genetic variation and population structure in Native Americans. PLoS Genet 3(11): e185. doi:10.1371/journal.pgen.0030185 1553-7390 http://hdl.handle.net/10495/23699 doi:10.1371/journal.pgen.0030185 1553-7404 |
op_rights |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pgen.0030185 |
container_title |
PLoS Genetics |
container_volume |
3 |
container_issue |
11 |
container_start_page |
e185 |
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1766378532473143296 |