Solvent-Free Enantioselective Organocatalyzed Aldol Reactions
The use of proline as catalyst for the aldol process has given a boost to the development of organocatalysis as a research area. Since then, a plethora of organocatalysts of diverse structures have been developed for this and other organic transformations under different reaction conditions. The use...
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ftunivalicante:oai:rua.ua.es:10045/44607 2023-05-15T17:53:51+02:00 Solvent-Free Enantioselective Organocatalyzed Aldol Reactions Bañón Caballero, Abraham Guillena, Gabriela Nájera, Carmen Universidad de Alicante. Departamento de Química Orgánica Universidad de Alicante. Instituto Universitario de Síntesis Orgánica Catálisis Estereoselectiva en Síntesis Orgánica (CESO) Síntesis Asimétrica (SINTAS) 2014-05 http://hdl.handle.net/10045/44607 eng eng Bentham Science Publishers http://www.ingentaconnect.com/content/ben/mroc/2014/00000011/00000002/art00002?crawler=true Mini-Reviews in Organic Chemistry. 2014, 11(2): 118-128 1570-193X (Print) 1875-6298 (Online) http://hdl.handle.net/10045/44607 A7356386 © 2014 Bentham Science Publishers info:eu-repo/semantics/openAccess Aldol Asymmetric organocatalysis Enamine Green chemistry Proline Solvent-free Química Orgánica info:eu-repo/semantics/article 2014 ftunivalicante 2020-06-05T13:08:49Z The use of proline as catalyst for the aldol process has given a boost to the development of organocatalysis as a research area. Since then, a plethora of organocatalysts of diverse structures have been developed for this and other organic transformations under different reaction conditions. The use of an organic molecule as catalyst to promote a reaction meets several principles of Green Chemistry. The implementation of solvent-free methodologies to carry out the aldol reaction was soon envisaged. These solvent-free processes can be performed using conventional magnetic stirring or applying ball milling techniques and are even compatible with the use of supported organocatalysts as promoters, which allows the recovery and reuse of the organocatalysts. In addition, other advantages such as the reduction of the required amount of nucleophile and the acceleration of the reaction are accomplished by using solvent-free conditions leading to a “greener” and more sustainable process. This research was supported by the Ministerio de Ciencia Innovación (MICINN: Projects CTQ2007-62771/BQU, CTQ2010-20387, and Consolider Ingenio 2010 CSD2007-00006), FEDER, the Generalitat Valenciana (Project PROMETE0/2009/039), the University of Alicante and the EU (ORCA action CM0905). A.B.C. thanks the Spanish ME for a predoctoral fellowship (FPU AP2009-3601). Article in Journal/Newspaper Orca RUA - Repositorio Institucional de la Universidad de Alicante |
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Open Polar |
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RUA - Repositorio Institucional de la Universidad de Alicante |
op_collection_id |
ftunivalicante |
language |
English |
topic |
Aldol Asymmetric organocatalysis Enamine Green chemistry Proline Solvent-free Química Orgánica |
spellingShingle |
Aldol Asymmetric organocatalysis Enamine Green chemistry Proline Solvent-free Química Orgánica Bañón Caballero, Abraham Guillena, Gabriela Nájera, Carmen Solvent-Free Enantioselective Organocatalyzed Aldol Reactions |
topic_facet |
Aldol Asymmetric organocatalysis Enamine Green chemistry Proline Solvent-free Química Orgánica |
description |
The use of proline as catalyst for the aldol process has given a boost to the development of organocatalysis as a research area. Since then, a plethora of organocatalysts of diverse structures have been developed for this and other organic transformations under different reaction conditions. The use of an organic molecule as catalyst to promote a reaction meets several principles of Green Chemistry. The implementation of solvent-free methodologies to carry out the aldol reaction was soon envisaged. These solvent-free processes can be performed using conventional magnetic stirring or applying ball milling techniques and are even compatible with the use of supported organocatalysts as promoters, which allows the recovery and reuse of the organocatalysts. In addition, other advantages such as the reduction of the required amount of nucleophile and the acceleration of the reaction are accomplished by using solvent-free conditions leading to a “greener” and more sustainable process. This research was supported by the Ministerio de Ciencia Innovación (MICINN: Projects CTQ2007-62771/BQU, CTQ2010-20387, and Consolider Ingenio 2010 CSD2007-00006), FEDER, the Generalitat Valenciana (Project PROMETE0/2009/039), the University of Alicante and the EU (ORCA action CM0905). A.B.C. thanks the Spanish ME for a predoctoral fellowship (FPU AP2009-3601). |
author2 |
Universidad de Alicante. Departamento de Química Orgánica Universidad de Alicante. Instituto Universitario de Síntesis Orgánica Catálisis Estereoselectiva en Síntesis Orgánica (CESO) Síntesis Asimétrica (SINTAS) |
format |
Article in Journal/Newspaper |
author |
Bañón Caballero, Abraham Guillena, Gabriela Nájera, Carmen |
author_facet |
Bañón Caballero, Abraham Guillena, Gabriela Nájera, Carmen |
author_sort |
Bañón Caballero, Abraham |
title |
Solvent-Free Enantioselective Organocatalyzed Aldol Reactions |
title_short |
Solvent-Free Enantioselective Organocatalyzed Aldol Reactions |
title_full |
Solvent-Free Enantioselective Organocatalyzed Aldol Reactions |
title_fullStr |
Solvent-Free Enantioselective Organocatalyzed Aldol Reactions |
title_full_unstemmed |
Solvent-Free Enantioselective Organocatalyzed Aldol Reactions |
title_sort |
solvent-free enantioselective organocatalyzed aldol reactions |
publisher |
Bentham Science Publishers |
publishDate |
2014 |
url |
http://hdl.handle.net/10045/44607 |
genre |
Orca |
genre_facet |
Orca |
op_relation |
http://www.ingentaconnect.com/content/ben/mroc/2014/00000011/00000002/art00002?crawler=true Mini-Reviews in Organic Chemistry. 2014, 11(2): 118-128 1570-193X (Print) 1875-6298 (Online) http://hdl.handle.net/10045/44607 A7356386 |
op_rights |
© 2014 Bentham Science Publishers info:eu-repo/semantics/openAccess |
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1766161556411777024 |