Palladium and organocatalysis: an excellent recipe for asymmetric synthesis

• Published in: Molecules
• Main Authors: Fernández Ibáñez, María Ángeles, Maciá, Beatriz, Alonso, Diego A., Pastor, Isidro M.
• Other Authors: Universidad de Alicante. Departamento de Química Orgánica, Catálisis Estereoselectiva en Síntesis Orgánica (CESO), Nuevos Materiales y Catalizadores (MATCAT)
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI 2013
• Subjects: Palladium; Organocatalysis; Asymmetric synthesis; Dual activation; Tandem reaction; Allylation; Fluorination; Decarboxylative protonation; Química Orgánica; Orca
• Online Access: http://hdl.handle.net/10045/33642; https://doi.org/10.3390/molecules180910108

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology. MAFI thanks financial support from the Ministerio de Economía y Competitividad (MINECO, CTQ 2012-35790) and the Consejería de Educación de la Comunidad de Madrid (programme AVANCAT, S2009/PPQ-1634). BM thanks the European Commission for a Marie Curie Integration Grant (FP7-PEOPLE-2012-CIG). IMP thanks financial support from the Ministerio de Ciencia e Innovación (MICINN) of Spain (CTQ2011-24165) and from the University of Alicante. DAA thanks financial support for the European Union (ORCA action CM0905) and from the University of Alicante.