Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction
Fundamental aspects related to the analysis of nitric acid solutions by inductively coupled plasma mass spectrometry have been critically revisited in order to provide new insights into the possible sources of non-spectroscopic matrix effects and their correction by internal standardization. For ele...
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Online Access: | http://hdl.handle.net/10045/109046 https://doi.org/10.1039/D0JA00130A |
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ftunivalicante:oai:rua.ua.es:10045/109046 2023-05-15T13:46:48+02:00 Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction Grotti, Marco Todolí Torró, José Luis Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología Análisis de Polímeros y Nanomateriales 2020-06-19 http://hdl.handle.net/10045/109046 https://doi.org/10.1039/D0JA00130A eng eng Royal Society of Chemistry https://doi.org/10.1039/D0JA00130A info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-100711-B-I00 Journal of Analytical Atomic Spectrometry. 2020, 35: 1959-1968. https://doi.org/10.1039/D0JA00130A 0267-9477 (Print) 1364-5544 (Online) http://hdl.handle.net/10045/109046 doi:10.1039/D0JA00130A © The Royal Society of Chemistry 2020 info:eu-repo/semantics/restrictedAccess Nitric acid effect Inductively coupled plasma Mass spectrometry Química Analítica info:eu-repo/semantics/article 2020 ftunivalicante https://doi.org/10.1039/D0JA00130A 2021-06-22T23:16:58Z Fundamental aspects related to the analysis of nitric acid solutions by inductively coupled plasma mass spectrometry have been critically revisited in order to provide new insights into the possible sources of non-spectroscopic matrix effects and their correction by internal standardization. For elements having first ionization potential (IP) lower than 7.5 eV, the increase in the signal due to nitric acid was ascribed to a delay in the ionization process, which resulted in a reduction of the ion lateral diffusion in the plasma. In contrast, for non-easily ionisable elements, signal depression was correlated with their IP value and attributed to the cooling effect due to the energy required for nitric acid dissociation. Moreover, the atomic mass did not show any significant effect, thus precluding the application of the widely accepted criterion of choice of internal standards based on matching of masses. The extent and sign of the acid effect also depended on the applied operating conditions. For elements with low IP (e.g. Co, Cs, In, Li, Pb, Y), nitric acid caused signal enhancement at high RF power and nebulizer gas flow rate values (i.e., plasma robust conditions) and signal depression under non-robust conditions. For elements with high IP (e.g. As, Be, Cd and Sb), the decreasing acid effect became stronger with increasing the nebulizer gas flow rate and decreasing the RF power. The acid effect was also influenced by the ion lens voltage, that significantly interacted with the RF power effect. Finally, a procedure for the selection of optimal internal standards by principal component analysis has been successfully applied for the correction of the nitric acid effect. This work has been funded by the Italian National Program of Research in Antarctica (projects PNRA14_00091 and PNRA16_00252) and the Spanish Ministry of Science, Innovation and Universities for the financial support (Project Ref. PGC2018-100711-B-I00). Article in Journal/Newspaper Antarc* Antarctica RUA - Repositorio Institucional de la Universidad de Alicante Journal of Analytical Atomic Spectrometry 35 9 1959 1968 |
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RUA - Repositorio Institucional de la Universidad de Alicante |
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language |
English |
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Nitric acid effect Inductively coupled plasma Mass spectrometry Química Analítica |
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Nitric acid effect Inductively coupled plasma Mass spectrometry Química Analítica Grotti, Marco Todolí Torró, José Luis Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
topic_facet |
Nitric acid effect Inductively coupled plasma Mass spectrometry Química Analítica |
description |
Fundamental aspects related to the analysis of nitric acid solutions by inductively coupled plasma mass spectrometry have been critically revisited in order to provide new insights into the possible sources of non-spectroscopic matrix effects and their correction by internal standardization. For elements having first ionization potential (IP) lower than 7.5 eV, the increase in the signal due to nitric acid was ascribed to a delay in the ionization process, which resulted in a reduction of the ion lateral diffusion in the plasma. In contrast, for non-easily ionisable elements, signal depression was correlated with their IP value and attributed to the cooling effect due to the energy required for nitric acid dissociation. Moreover, the atomic mass did not show any significant effect, thus precluding the application of the widely accepted criterion of choice of internal standards based on matching of masses. The extent and sign of the acid effect also depended on the applied operating conditions. For elements with low IP (e.g. Co, Cs, In, Li, Pb, Y), nitric acid caused signal enhancement at high RF power and nebulizer gas flow rate values (i.e., plasma robust conditions) and signal depression under non-robust conditions. For elements with high IP (e.g. As, Be, Cd and Sb), the decreasing acid effect became stronger with increasing the nebulizer gas flow rate and decreasing the RF power. The acid effect was also influenced by the ion lens voltage, that significantly interacted with the RF power effect. Finally, a procedure for the selection of optimal internal standards by principal component analysis has been successfully applied for the correction of the nitric acid effect. This work has been funded by the Italian National Program of Research in Antarctica (projects PNRA14_00091 and PNRA16_00252) and the Spanish Ministry of Science, Innovation and Universities for the financial support (Project Ref. PGC2018-100711-B-I00). |
author2 |
Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología Análisis de Polímeros y Nanomateriales |
format |
Article in Journal/Newspaper |
author |
Grotti, Marco Todolí Torró, José Luis |
author_facet |
Grotti, Marco Todolí Torró, José Luis |
author_sort |
Grotti, Marco |
title |
Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
title_short |
Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
title_full |
Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
title_fullStr |
Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
title_full_unstemmed |
Nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
title_sort |
nitric acid effect in inductively coupled plasma mass spectrometry: new insights on possible causes and correction |
publisher |
Royal Society of Chemistry |
publishDate |
2020 |
url |
http://hdl.handle.net/10045/109046 https://doi.org/10.1039/D0JA00130A |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
https://doi.org/10.1039/D0JA00130A info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-100711-B-I00 Journal of Analytical Atomic Spectrometry. 2020, 35: 1959-1968. https://doi.org/10.1039/D0JA00130A 0267-9477 (Print) 1364-5544 (Online) http://hdl.handle.net/10045/109046 doi:10.1039/D0JA00130A |
op_rights |
© The Royal Society of Chemistry 2020 info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1039/D0JA00130A |
container_title |
Journal of Analytical Atomic Spectrometry |
container_volume |
35 |
container_issue |
9 |
container_start_page |
1959 |
op_container_end_page |
1968 |
_version_ |
1766245240690180096 |