European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure
This study investigated Anguilla anguilla (European eel) physiological and genotoxic responses to copper (Cu) and their relation with metallothionein (MT) protection. Eels were exposed during 7 days to Cu 0.2 micromol/L. MT induction was assessed in gill and liver, revealing significant response onl...
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Online Access: | http://hdl.handle.net/10400.1/13841 https://doi.org/10.1016/j.ecoenv.2007.10.034 |
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ftunivalgarve:oai:sapientia.ualg.pt:10400.1/13841 2023-05-15T13:26:44+02:00 European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure Oliveira, M. Serafim, Angela Bebianno, Maria João Pacheco, M. Santos, M. A. 2008 http://hdl.handle.net/10400.1/13841 https://doi.org/10.1016/j.ecoenv.2007.10.034 eng eng Elsevier info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F27584%2F2006/PT https://www.sciencedirect.com/science/article/pii/S0147651307003028?via%3Dihub 0147-6513 http://hdl.handle.net/10400.1/13841 https://doi.org/10.1016/j.ecoenv.2007.10.034 restrictedAccess http://creativecommons.org/licenses/by/4.0/ CC-BY Anguilla Animals Blood glucose Cell nucleus Copper Erythrocytes Gills Hydrocortisone Kidney Lactic acid Liver Metallothionein Mutagens Triiodothyronine Water pollutants Chemical Anguilla anguilla T3 T4 Cortisol Genotoxicity article 2008 ftunivalgarve https://doi.org/10.1016/j.ecoenv.2007.10.034 2022-05-30T08:49:04Z This study investigated Anguilla anguilla (European eel) physiological and genotoxic responses to copper (Cu) and their relation with metallothionein (MT) protection. Eels were exposed during 7 days to Cu 0.2 micromol/L. MT induction was assessed in gill and liver, revealing significant response only in liver. Endocrine responses displayed a plasma free triiodothyronine (T3) and cortisol significant decrease, though the thyroid-stimulating hormone (TSH) and free thyroxine (T4) concentrations were unaltered. A significant plasma glucose increase was observed whereas lactate was significantly decreased. Despite the absence of DNA integrity decrease in blood, gill, liver and kidney, erythrocytic nuclear abnormalities (ENA) frequency significantly increased in Cu exposed group. MT induction was insufficient to prevent endocrine and metabolic alterations as well as genotoxicity/clastogenicity in blood. However, MT protection was evident in liver by preventing DNA integrity loss. Globally, it was demonstrated that Cu environmentally realistic levels may pose a serious ecological risk to fish. info:eu-repo/semantics/publishedVersion Article in Journal/Newspaper Anguilla anguilla Universidade do Algarve: Sapienta Ecotoxicology and Environmental Safety 70 1 20 26 |
institution |
Open Polar |
collection |
Universidade do Algarve: Sapienta |
op_collection_id |
ftunivalgarve |
language |
English |
topic |
Anguilla Animals Blood glucose Cell nucleus Copper Erythrocytes Gills Hydrocortisone Kidney Lactic acid Liver Metallothionein Mutagens Triiodothyronine Water pollutants Chemical Anguilla anguilla T3 T4 Cortisol Genotoxicity |
spellingShingle |
Anguilla Animals Blood glucose Cell nucleus Copper Erythrocytes Gills Hydrocortisone Kidney Lactic acid Liver Metallothionein Mutagens Triiodothyronine Water pollutants Chemical Anguilla anguilla T3 T4 Cortisol Genotoxicity Oliveira, M. Serafim, Angela Bebianno, Maria João Pacheco, M. Santos, M. A. European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
topic_facet |
Anguilla Animals Blood glucose Cell nucleus Copper Erythrocytes Gills Hydrocortisone Kidney Lactic acid Liver Metallothionein Mutagens Triiodothyronine Water pollutants Chemical Anguilla anguilla T3 T4 Cortisol Genotoxicity |
description |
This study investigated Anguilla anguilla (European eel) physiological and genotoxic responses to copper (Cu) and their relation with metallothionein (MT) protection. Eels were exposed during 7 days to Cu 0.2 micromol/L. MT induction was assessed in gill and liver, revealing significant response only in liver. Endocrine responses displayed a plasma free triiodothyronine (T3) and cortisol significant decrease, though the thyroid-stimulating hormone (TSH) and free thyroxine (T4) concentrations were unaltered. A significant plasma glucose increase was observed whereas lactate was significantly decreased. Despite the absence of DNA integrity decrease in blood, gill, liver and kidney, erythrocytic nuclear abnormalities (ENA) frequency significantly increased in Cu exposed group. MT induction was insufficient to prevent endocrine and metabolic alterations as well as genotoxicity/clastogenicity in blood. However, MT protection was evident in liver by preventing DNA integrity loss. Globally, it was demonstrated that Cu environmentally realistic levels may pose a serious ecological risk to fish. info:eu-repo/semantics/publishedVersion |
format |
Article in Journal/Newspaper |
author |
Oliveira, M. Serafim, Angela Bebianno, Maria João Pacheco, M. Santos, M. A. |
author_facet |
Oliveira, M. Serafim, Angela Bebianno, Maria João Pacheco, M. Santos, M. A. |
author_sort |
Oliveira, M. |
title |
European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
title_short |
European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
title_full |
European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
title_fullStr |
European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
title_full_unstemmed |
European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
title_sort |
european eel (anguilla anguilla l.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure |
publisher |
Elsevier |
publishDate |
2008 |
url |
http://hdl.handle.net/10400.1/13841 https://doi.org/10.1016/j.ecoenv.2007.10.034 |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_relation |
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F27584%2F2006/PT https://www.sciencedirect.com/science/article/pii/S0147651307003028?via%3Dihub 0147-6513 http://hdl.handle.net/10400.1/13841 https://doi.org/10.1016/j.ecoenv.2007.10.034 |
op_rights |
restrictedAccess http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1016/j.ecoenv.2007.10.034 |
container_title |
Ecotoxicology and Environmental Safety |
container_volume |
70 |
container_issue |
1 |
container_start_page |
20 |
op_container_end_page |
26 |
_version_ |
1766394123514806272 |