Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit
"Objectives: To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design: Candidate gene association study of discrete and quantitative traits related to card...
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Online Access: | https://era.library.ualberta.ca/items/e748b42a-9db3-40a6-91e4-a8299d362ab1 https://doi.org/10.7939/r3-173x-qk64 |
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ftunivalberta:oai:era.library.ualberta.ca:e748b42a-9db3-40a6-91e4-a8299d362ab1 2024-06-23T07:53:09+00:00 Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. 2012-03-18T00:00:00+00:00 https://era.library.ualberta.ca/items/e748b42a-9db3-40a6-91e4-a8299d362ab1 https://doi.org/10.7939/r3-173x-qk64 English eng https://era.library.ualberta.ca/items/e748b42a-9db3-40a6-91e4-a8299d362ab1 doi:10.7939/r3-173x-qk64 http://creativecommons.org/licenses/by/4.0/ Adipose triglyceride lipase Cardiovascular disease Genetic association study Haplotype analysis Single nucleotide polymorphisms Triglyceride-rich lipoproteins Article (Published) 2012 ftunivalberta https://doi.org/10.7939/r3-173x-qk64 2024-06-03T03:09:00Z "Objectives: To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design: Candidate gene association study of discrete and quantitative traits related to cardiovascular health. Methods: ATGL was sequenced in 10 European subjects to identify DNA sequence variants. The identified polymorphisms were subsequently genotyped in a population-based cohort of 1,218 unrelated Greenland Inuit subjects, ascertained from the Greenland Population Study. Genotypes and reconstructed haplotypes were tested for association with cardiovascular disease risk factors using additive, dominant or recessive models, corrected for age, sex and body mass index." (as cited in abstract) Article in Journal/Newspaper Greenland inuit University of Alberta: Era - Education and Research Archive Greenland |
institution |
Open Polar |
collection |
University of Alberta: Era - Education and Research Archive |
op_collection_id |
ftunivalberta |
language |
English |
topic |
Adipose triglyceride lipase Cardiovascular disease Genetic association study Haplotype analysis Single nucleotide polymorphisms Triglyceride-rich lipoproteins |
spellingShingle |
Adipose triglyceride lipase Cardiovascular disease Genetic association study Haplotype analysis Single nucleotide polymorphisms Triglyceride-rich lipoproteins Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit |
topic_facet |
Adipose triglyceride lipase Cardiovascular disease Genetic association study Haplotype analysis Single nucleotide polymorphisms Triglyceride-rich lipoproteins |
description |
"Objectives: To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design: Candidate gene association study of discrete and quantitative traits related to cardiovascular health. Methods: ATGL was sequenced in 10 European subjects to identify DNA sequence variants. The identified polymorphisms were subsequently genotyped in a population-based cohort of 1,218 unrelated Greenland Inuit subjects, ascertained from the Greenland Population Study. Genotypes and reconstructed haplotypes were tested for association with cardiovascular disease risk factors using additive, dominant or recessive models, corrected for age, sex and body mass index." (as cited in abstract) |
format |
Article in Journal/Newspaper |
author |
Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. |
author_facet |
Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. |
author_sort |
Johansen, Christopher T. |
title |
Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit |
title_short |
Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit |
title_full |
Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit |
title_fullStr |
Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit |
title_full_unstemmed |
Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit |
title_sort |
rare atgl haplotypes are associated with increased plasma triglyceride concentrations in the greenland inuit |
publishDate |
2012 |
url |
https://era.library.ualberta.ca/items/e748b42a-9db3-40a6-91e4-a8299d362ab1 https://doi.org/10.7939/r3-173x-qk64 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_relation |
https://era.library.ualberta.ca/items/e748b42a-9db3-40a6-91e4-a8299d362ab1 doi:10.7939/r3-173x-qk64 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.7939/r3-173x-qk64 |
_version_ |
1802644650309189632 |