Adherence and barriers to H. pylori treatment in Arctic Canada.
Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for co...
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ftunivalberta:oai:era.library.ualberta.ca:3b8458bd-badf-4ac3-b0e6-04a7025b7812 2023-05-15T13:08:02+02:00 Adherence and barriers to H. pylori treatment in Arctic Canada. van Zanten, S.V. Chang, H.J. Morse, A. Lefebvre, M. Goodman, K.J. 2014 https://era.library.ualberta.ca/items/3b8458bd-badf-4ac3-b0e6-04a7025b7812 https://doi.org/10.7939/R38911Q90 English eng https://era.library.ualberta.ca/items/3b8458bd-badf-4ac3-b0e6-04a7025b7812 doi:10.7939/R38911Q90 http://creativecommons.org/licenses/by-nc/3.0/ CC-BY-NC Circumpolar regions Aboriginal health Helicobacter pylori Cancer Peptic ulcers Article (Published) 2014 ftunivalberta https://doi.org/10.7939/R38911Q90 2022-08-22T20:10:14Z Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for common stomach complaints, leading to frequent demand for treatment, which often fails. Moreover, public health authorities identified the need for information to develop locally appropriate H. pylori control strategies. We described adherence and identified barriers to completing treatment among H. pylori-positive participants in a community-based project inspired by local concerns about H. pylori infection risks. Methods. In 2008, 110 H. pylori-positive participants (diagnosed by a breath test, histopathology and/or culture) of the Aklavik H. pylori project were randomised to standard-of-care or sequential treatment. We ascertained adherence by interviewing participants using a structured questionnaire. We estimated adherence frequencies as the proportion of participants who reported taking either 100% of doses (perfect adherence) or ≥80% of doses (good adherence). To compare the proportion with perfect or good adherence in subgroups, we report proportion differences and 95% confidence intervals (CI). Results. Of 87 participants who were interviewed, 64% reported perfect adherence and 80% reported good adherence. We observed more frequent perfect adherence for: standard therapy (67%) versus sequential (62%); males (76%) versus females (52%); participants 40–77 years (79%) versus 17–39 (50%). Proportion differences were 5% (CI: −15, 25) for standard versus sequential therapy; 23% (CI: 4, 43) for male versus female; and 29% (CI: 10, 48) for 40–77 versus 15–39 years for perfect adherence. Of the 29 participants who reported poor adherence (<80% of doses taken), the following barriers to treatment were reported: changed mind about taking treatment (24%), consumption of alcoholic beverages (18%), nausea (18%), ... Other/Unknown Material Aklavik Arctic University of Alberta: Era - Education and Research Archive Aklavik ENVELOPE(-135.011,-135.011,68.219,68.219) Arctic Canada |
institution |
Open Polar |
collection |
University of Alberta: Era - Education and Research Archive |
op_collection_id |
ftunivalberta |
language |
English |
topic |
Circumpolar regions Aboriginal health Helicobacter pylori Cancer Peptic ulcers |
spellingShingle |
Circumpolar regions Aboriginal health Helicobacter pylori Cancer Peptic ulcers van Zanten, S.V. Chang, H.J. Morse, A. Lefebvre, M. Goodman, K.J. Adherence and barriers to H. pylori treatment in Arctic Canada. |
topic_facet |
Circumpolar regions Aboriginal health Helicobacter pylori Cancer Peptic ulcers |
description |
Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for common stomach complaints, leading to frequent demand for treatment, which often fails. Moreover, public health authorities identified the need for information to develop locally appropriate H. pylori control strategies. We described adherence and identified barriers to completing treatment among H. pylori-positive participants in a community-based project inspired by local concerns about H. pylori infection risks. Methods. In 2008, 110 H. pylori-positive participants (diagnosed by a breath test, histopathology and/or culture) of the Aklavik H. pylori project were randomised to standard-of-care or sequential treatment. We ascertained adherence by interviewing participants using a structured questionnaire. We estimated adherence frequencies as the proportion of participants who reported taking either 100% of doses (perfect adherence) or ≥80% of doses (good adherence). To compare the proportion with perfect or good adherence in subgroups, we report proportion differences and 95% confidence intervals (CI). Results. Of 87 participants who were interviewed, 64% reported perfect adherence and 80% reported good adherence. We observed more frequent perfect adherence for: standard therapy (67%) versus sequential (62%); males (76%) versus females (52%); participants 40–77 years (79%) versus 17–39 (50%). Proportion differences were 5% (CI: −15, 25) for standard versus sequential therapy; 23% (CI: 4, 43) for male versus female; and 29% (CI: 10, 48) for 40–77 versus 15–39 years for perfect adherence. Of the 29 participants who reported poor adherence (<80% of doses taken), the following barriers to treatment were reported: changed mind about taking treatment (24%), consumption of alcoholic beverages (18%), nausea (18%), ... |
format |
Other/Unknown Material |
author |
van Zanten, S.V. Chang, H.J. Morse, A. Lefebvre, M. Goodman, K.J. |
author_facet |
van Zanten, S.V. Chang, H.J. Morse, A. Lefebvre, M. Goodman, K.J. |
author_sort |
van Zanten, S.V. |
title |
Adherence and barriers to H. pylori treatment in Arctic Canada. |
title_short |
Adherence and barriers to H. pylori treatment in Arctic Canada. |
title_full |
Adherence and barriers to H. pylori treatment in Arctic Canada. |
title_fullStr |
Adherence and barriers to H. pylori treatment in Arctic Canada. |
title_full_unstemmed |
Adherence and barriers to H. pylori treatment in Arctic Canada. |
title_sort |
adherence and barriers to h. pylori treatment in arctic canada. |
publishDate |
2014 |
url |
https://era.library.ualberta.ca/items/3b8458bd-badf-4ac3-b0e6-04a7025b7812 https://doi.org/10.7939/R38911Q90 |
long_lat |
ENVELOPE(-135.011,-135.011,68.219,68.219) |
geographic |
Aklavik Arctic Canada |
geographic_facet |
Aklavik Arctic Canada |
genre |
Aklavik Arctic |
genre_facet |
Aklavik Arctic |
op_relation |
https://era.library.ualberta.ca/items/3b8458bd-badf-4ac3-b0e6-04a7025b7812 doi:10.7939/R38911Q90 |
op_rights |
http://creativecommons.org/licenses/by-nc/3.0/ |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.7939/R38911Q90 |
_version_ |
1766072591454306304 |