Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels

•Worldwide hemorrhagic shock is the number one cause of death in trauma patients, the majority of those die from multi organ dysfunction syndrome [1, 2]. •During hemorrhagic shock (HS), the body undergoes global ischemia as blood pressure drops below the threshold at which tissues can be adequately...

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Main Authors: Bogren, Lori, Olson, JM, Carpluk, J, Moore, JT, Drew, KL
Language:unknown
Published: 2012
Subjects:
Institute of Arctic Biology
Alaska
Online Access:http://hdl.handle.net/11122/1483
id ftunivalaska:oai:scholarworks.alaska.edu:11122/1483
record_format openpolar
spelling ftunivalaska:oai:scholarworks.alaska.edu:11122/1483 2024-09-15T18:14:48+00:00 Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels Bogren, Lori Olson, JM Carpluk, J Moore, JT Drew, KL 2012 http://hdl.handle.net/11122/1483 unknown http://hdl.handle.net/11122/1483 2012 ftunivalaska 2024-08-12T03:04:02Z •Worldwide hemorrhagic shock is the number one cause of death in trauma patients, the majority of those die from multi organ dysfunction syndrome [1, 2]. •During hemorrhagic shock (HS), the body undergoes global ischemia as blood pressure drops below the threshold at which tissues can be adequately perfused with blood. •Resistance to ischemic injury is a characteristic of hibernating mammals, including ground squirrels. •There is debate on if this resistance is dependant on hibernation season or if it is an intrinsic plasticity of the organism. QUESTION: Are AGS protected from HS‐induced ischemia reperfusion (I/R) injury on the whole organism and tissue–specific levels and if any protection is dependent upon their hibernation season. University of Alaska Fairbanks, Institute of Arctic Biology, Department of Chemistry and Biochemistry Other/Unknown Material Institute of Arctic Biology Alaska University of Alaska: ScholarWorks@UA
institution Open Polar
collection University of Alaska: ScholarWorks@UA
op_collection_id ftunivalaska
language unknown
description •Worldwide hemorrhagic shock is the number one cause of death in trauma patients, the majority of those die from multi organ dysfunction syndrome [1, 2]. •During hemorrhagic shock (HS), the body undergoes global ischemia as blood pressure drops below the threshold at which tissues can be adequately perfused with blood. •Resistance to ischemic injury is a characteristic of hibernating mammals, including ground squirrels. •There is debate on if this resistance is dependant on hibernation season or if it is an intrinsic plasticity of the organism. QUESTION: Are AGS protected from HS‐induced ischemia reperfusion (I/R) injury on the whole organism and tissue–specific levels and if any protection is dependent upon their hibernation season. University of Alaska Fairbanks, Institute of Arctic Biology, Department of Chemistry and Biochemistry
author Bogren, Lori
Olson, JM
Carpluk, J
Moore, JT
Drew, KL
spellingShingle Bogren, Lori
Olson, JM
Carpluk, J
Moore, JT
Drew, KL
Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
author_facet Bogren, Lori
Olson, JM
Carpluk, J
Moore, JT
Drew, KL
author_sort Bogren, Lori
title Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
title_short Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
title_full Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
title_fullStr Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
title_full_unstemmed Resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
title_sort resistance to multi organ damage after hemorrhagic shock induced ischemia/reperfusion in arctic ground squirrels
publishDate 2012
url http://hdl.handle.net/11122/1483
genre Institute of Arctic Biology
Alaska
genre_facet Institute of Arctic Biology
Alaska
op_relation http://hdl.handle.net/11122/1483
_version_ 1810452575316606976

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