Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring
International audience Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were expos...
Published in: | International Journal for Vitamin and Nutrition Research |
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Online Access: | https://hal.science/hal-04502425 https://doi.org/10.1024/0300-9831/a000288 |
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ftunivaixmarseil:oai:HAL:hal-04502425v1 2024-04-14T08:01:03+00:00 Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring Dridi, Imen Soualeh, Nidhal Bohn, Torsten Soulimani, Rachid Bouayed, Jaouad Laboratoire de Conception, Optimisation et Modélisation des Systèmes (LCOMS) Université de Lorraine (UL) Faculté des Sciences de Bizerte Université de Carthage Université de Carthage (Tunisie) (UCAR) Luxembourg Institute of Health (LIH) Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN) Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) 2016-02 https://hal.science/hal-04502425 https://doi.org/10.1024/0300-9831/a000288 en eng HAL CCSD Hogrefe info:eu-repo/semantics/altIdentifier/doi/10.1024/0300-9831/a000288 hal-04502425 https://hal.science/hal-04502425 doi:10.1024/0300-9831/a000288 ISSN: 0300-9831 International Journal for Vitamin and Nutrition Research https://hal.science/hal-04502425 International Journal for Vitamin and Nutrition Research, 2016, 86 (1-2), pp.36-47. ⟨10.1024/0300-9831/a000288⟩ Eels hyperactivity umbilical cord vitamin C [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2016 ftunivaixmarseil https://doi.org/10.1024/0300-9831/a000288 2024-03-21T16:50:58Z International audience Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were exposed during gestation and lactation, through diets enriched in eels naturally contaminated with pollutants including PCBs. Analysis of the eel muscle focused on the six non-dioxin-like (NDL) indicator PCBs (Σ6 NDL-PCBs: 28, 52, 101, 138, 153 and 180). Four groups of dams (n = 10 per group) received either a standard diet without eels or eels (0.8 mg/kg/day) containing 85, 216, or 400 ng/kg/day of ϵ6 NDL-PCBs. The open field test showed that early-life exposure to polluted eels increased locomotion in female offspring of exposed dams but not in males, compared to controls. This hyperlocomotion appeared later in life, at PNDs 195 and 329 (up to 32 % increase, p < 0.05). In addition, overactivity was observed in the home cage test at PND 305: exposed offspring females showed a faster overall locomotion speed (3.6 – 4.2 cm/s) than controls (2.9 cm/s, p <0.05); again, males remained unaffected. Covered distances in the home cage test were only elevated significantly in offspring females exposed to highest PCB concentrations (3411 ± 590 cm vs. 1377 ± 114 cm, p < 0.001). These results suggest that early-life exposure to polluted eels containing dietary contaminants including PCBs caused late, persistent and gender-dependent neurobehavioral hyperactive effects in offspring mice. Furthermore, female hyperactivity was associated with a significant inhibition of acetylcholinesterase activity in the hippocampus and the prefrontal cortex. Article in Journal/Newspaper Anguilla anguilla Aix-Marseille Université: HAL International Journal for Vitamin and Nutrition Research 86 1-2 36 47 |
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Open Polar |
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Aix-Marseille Université: HAL |
op_collection_id |
ftunivaixmarseil |
language |
English |
topic |
Eels hyperactivity umbilical cord vitamin C [SDV]Life Sciences [q-bio] |
spellingShingle |
Eels hyperactivity umbilical cord vitamin C [SDV]Life Sciences [q-bio] Dridi, Imen Soualeh, Nidhal Bohn, Torsten Soulimani, Rachid Bouayed, Jaouad Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring |
topic_facet |
Eels hyperactivity umbilical cord vitamin C [SDV]Life Sciences [q-bio] |
description |
International audience Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were exposed during gestation and lactation, through diets enriched in eels naturally contaminated with pollutants including PCBs. Analysis of the eel muscle focused on the six non-dioxin-like (NDL) indicator PCBs (Σ6 NDL-PCBs: 28, 52, 101, 138, 153 and 180). Four groups of dams (n = 10 per group) received either a standard diet without eels or eels (0.8 mg/kg/day) containing 85, 216, or 400 ng/kg/day of ϵ6 NDL-PCBs. The open field test showed that early-life exposure to polluted eels increased locomotion in female offspring of exposed dams but not in males, compared to controls. This hyperlocomotion appeared later in life, at PNDs 195 and 329 (up to 32 % increase, p < 0.05). In addition, overactivity was observed in the home cage test at PND 305: exposed offspring females showed a faster overall locomotion speed (3.6 – 4.2 cm/s) than controls (2.9 cm/s, p <0.05); again, males remained unaffected. Covered distances in the home cage test were only elevated significantly in offspring females exposed to highest PCB concentrations (3411 ± 590 cm vs. 1377 ± 114 cm, p < 0.001). These results suggest that early-life exposure to polluted eels containing dietary contaminants including PCBs caused late, persistent and gender-dependent neurobehavioral hyperactive effects in offspring mice. Furthermore, female hyperactivity was associated with a significant inhibition of acetylcholinesterase activity in the hippocampus and the prefrontal cortex. |
author2 |
Laboratoire de Conception, Optimisation et Modélisation des Systèmes (LCOMS) Université de Lorraine (UL) Faculté des Sciences de Bizerte Université de Carthage Université de Carthage (Tunisie) (UCAR) Luxembourg Institute of Health (LIH) Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN) Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
format |
Article in Journal/Newspaper |
author |
Dridi, Imen Soualeh, Nidhal Bohn, Torsten Soulimani, Rachid Bouayed, Jaouad |
author_facet |
Dridi, Imen Soualeh, Nidhal Bohn, Torsten Soulimani, Rachid Bouayed, Jaouad |
author_sort |
Dridi, Imen |
title |
Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring |
title_short |
Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring |
title_full |
Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring |
title_fullStr |
Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring |
title_full_unstemmed |
Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring |
title_sort |
chemically contaminated eel fed to pregnant and lactating mouse dams causes hyperactivity in their offspring |
publisher |
HAL CCSD |
publishDate |
2016 |
url |
https://hal.science/hal-04502425 https://doi.org/10.1024/0300-9831/a000288 |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_source |
ISSN: 0300-9831 International Journal for Vitamin and Nutrition Research https://hal.science/hal-04502425 International Journal for Vitamin and Nutrition Research, 2016, 86 (1-2), pp.36-47. ⟨10.1024/0300-9831/a000288⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1024/0300-9831/a000288 hal-04502425 https://hal.science/hal-04502425 doi:10.1024/0300-9831/a000288 |
op_doi |
https://doi.org/10.1024/0300-9831/a000288 |
container_title |
International Journal for Vitamin and Nutrition Research |
container_volume |
86 |
container_issue |
1-2 |
container_start_page |
36 |
op_container_end_page |
47 |
_version_ |
1796306893281427456 |