U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery
BACKGROUND/OBJECTIVES: Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-cha...
Published in: | European Journal of Clinical Nutrition |
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Online Access: | http://hdl.handle.net/2440/89709 https://doi.org/10.1038/ejcn.2013.215 |
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ftunivadelaidedl:oai:digital.library.adelaide.edu.au:2440/89709 2023-12-24T10:17:57+01:00 U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery Metcalf, R. Skuladottir, G. Indridason, O. Sullivan, T. Bjorgvinsdottir, L. Sanders, P. Arnar, D. Gibson, R. Heidarsdottir, R. Cleland, L. Palsson, R. Farquharson, A. Young, G. James, M. 2014 http://hdl.handle.net/2440/89709 https://doi.org/10.1038/ejcn.2013.215 en eng Nature Publishing Group http://purl.org/au-research/grants/nhmrc/399333 European Journal of Clinical Nutrition, 2014; 68(1):114-118 0954-3007 1476-5640 http://hdl.handle.net/2440/89709 doi:10.1038/ejcn.2013.215 Sanders, P. [0000-0003-3803-8429] Gibson, R. [0000-0002-8750-525X] James, M. [0000-0002-4918-2998] © 2014 Macmillan Publishers Limited http://dx.doi.org/10.1038/ejcn.2013.215 omega-3 fatty acids docosahexaenoic acid atrial fibrillation cardiac surgery Journal article 2014 ftunivadelaidedl https://doi.org/10.1038/ejcn.2013.215 2023-11-27T23:18:28Z BACKGROUND/OBJECTIVES: Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and the incidence of POAF. SUBJECTS/METHODS: We used combined data (n=355) from RCTs conducted in Australia and Iceland. The primary end point was defined as POAF lasting >10 min in the first 6 days following surgery. The odds ratios (ORs) for POAF were compared between quintiles of preoperative RBC n-3 LC-PUFA levels by multivariable logistic regression. RESULTS: Subjects with RBC docosahexaenoic acid (DHA) in the fourth quintile, comprising a RBC DHA range of 7.0-7.9%, had the lowest incidence of POAF. Subjects in the lowest and highest quintiles had significantly higher risk of developing POAF compared with those in the fourth quintile (OR=2.36: 95% CI; 1.07-5.24 and OR=2.45: 95% CI; 1.16-5.17, respectively). There was no association between RBC eicosapentaenoic acid levels and POAF incidence. CONCLUSIONS: The results suggest a 'U-shaped' relationship between RBC DHA levels and POAF incidence. The possibility of increased risk of POAF at high levels of DHA suggests an upper limit for n-3 LC-PUFAs in certain conditions. R G Metcalf, G V Skuladottir, O S Indridason, T R Sullivan, L Bjorgvinsdottir, P Sanders, D O Arnar, R A Gibson, R Heidarsdottir, L G Cleland, R Palsson, A L Farquharson, G D Young, and M J James Article in Journal/Newspaper Iceland The University of Adelaide: Digital Library Sullivan ENVELOPE(-63.817,-63.817,-69.650,-69.650) European Journal of Clinical Nutrition 68 1 114 118 |
institution |
Open Polar |
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The University of Adelaide: Digital Library |
op_collection_id |
ftunivadelaidedl |
language |
English |
topic |
omega-3 fatty acids docosahexaenoic acid atrial fibrillation cardiac surgery |
spellingShingle |
omega-3 fatty acids docosahexaenoic acid atrial fibrillation cardiac surgery Metcalf, R. Skuladottir, G. Indridason, O. Sullivan, T. Bjorgvinsdottir, L. Sanders, P. Arnar, D. Gibson, R. Heidarsdottir, R. Cleland, L. Palsson, R. Farquharson, A. Young, G. James, M. U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
topic_facet |
omega-3 fatty acids docosahexaenoic acid atrial fibrillation cardiac surgery |
description |
BACKGROUND/OBJECTIVES: Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and the incidence of POAF. SUBJECTS/METHODS: We used combined data (n=355) from RCTs conducted in Australia and Iceland. The primary end point was defined as POAF lasting >10 min in the first 6 days following surgery. The odds ratios (ORs) for POAF were compared between quintiles of preoperative RBC n-3 LC-PUFA levels by multivariable logistic regression. RESULTS: Subjects with RBC docosahexaenoic acid (DHA) in the fourth quintile, comprising a RBC DHA range of 7.0-7.9%, had the lowest incidence of POAF. Subjects in the lowest and highest quintiles had significantly higher risk of developing POAF compared with those in the fourth quintile (OR=2.36: 95% CI; 1.07-5.24 and OR=2.45: 95% CI; 1.16-5.17, respectively). There was no association between RBC eicosapentaenoic acid levels and POAF incidence. CONCLUSIONS: The results suggest a 'U-shaped' relationship between RBC DHA levels and POAF incidence. The possibility of increased risk of POAF at high levels of DHA suggests an upper limit for n-3 LC-PUFAs in certain conditions. R G Metcalf, G V Skuladottir, O S Indridason, T R Sullivan, L Bjorgvinsdottir, P Sanders, D O Arnar, R A Gibson, R Heidarsdottir, L G Cleland, R Palsson, A L Farquharson, G D Young, and M J James |
format |
Article in Journal/Newspaper |
author |
Metcalf, R. Skuladottir, G. Indridason, O. Sullivan, T. Bjorgvinsdottir, L. Sanders, P. Arnar, D. Gibson, R. Heidarsdottir, R. Cleland, L. Palsson, R. Farquharson, A. Young, G. James, M. |
author_facet |
Metcalf, R. Skuladottir, G. Indridason, O. Sullivan, T. Bjorgvinsdottir, L. Sanders, P. Arnar, D. Gibson, R. Heidarsdottir, R. Cleland, L. Palsson, R. Farquharson, A. Young, G. James, M. |
author_sort |
Metcalf, R. |
title |
U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
title_short |
U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
title_full |
U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
title_fullStr |
U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
title_full_unstemmed |
U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
title_sort |
u-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery |
publisher |
Nature Publishing Group |
publishDate |
2014 |
url |
http://hdl.handle.net/2440/89709 https://doi.org/10.1038/ejcn.2013.215 |
long_lat |
ENVELOPE(-63.817,-63.817,-69.650,-69.650) |
geographic |
Sullivan |
geographic_facet |
Sullivan |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
http://dx.doi.org/10.1038/ejcn.2013.215 |
op_relation |
http://purl.org/au-research/grants/nhmrc/399333 European Journal of Clinical Nutrition, 2014; 68(1):114-118 0954-3007 1476-5640 http://hdl.handle.net/2440/89709 doi:10.1038/ejcn.2013.215 Sanders, P. [0000-0003-3803-8429] Gibson, R. [0000-0002-8750-525X] James, M. [0000-0002-4918-2998] |
op_rights |
© 2014 Macmillan Publishers Limited |
op_doi |
https://doi.org/10.1038/ejcn.2013.215 |
container_title |
European Journal of Clinical Nutrition |
container_volume |
68 |
container_issue |
1 |
container_start_page |
114 |
op_container_end_page |
118 |
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1786206416009166848 |